The Use of Nonsteroidal Anti-Inflammatory Drugs for Exercise-Induced Muscle Damage

2012 ◽  
Vol 42 (12) ◽  
pp. 1017-1028 ◽  
Author(s):  
Brad J. Schoenfeld
Keyword(s):  
Muscle Damage ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Exercise Induced

scholarly journals Nonsteroidal Anti-Inflammatory Drug Use and Endurance During Running in Male Long-Distance Runners

2015 ◽  
Vol 50 (3) ◽  
pp. 295-302 ◽  
Author(s):  
Eduardo Da Silva ◽  
Ronei S. Pinto ◽  
Eduardo L. Cadore ◽  
Luiz F. Kruel
Keyword(s):  
Oxygen Consumption ◽  
Placebo Group ◽  
Muscle Damage ◽  
Endurance Performance ◽  
Distance Runners ◽  
Long Distance ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Exercise Induced ◽  
Ibuprofen Group

Context: The effect of ibuprofen on pain tolerance during exercise is controversial, and its effects on endurance performance have been poorly investigated. Objective: To investigate the effect of prophylactic administration of the nonsteroidal anti-inflammatory drug ibuprofen on the time until the self-report of fatigue (tlim) in runners with exercise-induced muscle damage. Design: Randomized controlled clinical trial. Setting: Laboratory. Patients or Other Participants: Twenty healthy male long-distance runners (age = 18.8 ± 0.4 years, maximal oxygen consumption = 55.5 ± 5.9 mL·kg−1·min−1). Intervention(s): Participants were assigned to 2 groups (ibuprofen group = 10, placebo group = 10) to perform tlim trials (speed corresponded to their previously determined secondventilatory thresholds) 48 hours before and 48 hours after the induction of a lower limb muscle-damage protocol (isokinetic dynamometry). One hour before the second tlim trial, the ibuprofen group received 1.2 g ibuprofen, and the placebo group received lactose orally. Main Outcome Measure(s): Time until self-reported fatigue, heart rate, respiratory quotient, oxygen consumption, and perceived exertion were recorded during each tlim test. Results: Both groups reported increases in muscle pain in the knee extensors and flexors 48 hours after the muscle-damage protocol. We observed a reduction in the endurance performance of both groups (P < .01) but no difference between groups (P = .55). Conclusions: Ibuprofen did not reduce the effect of muscle damage and pain on performance. Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners.

The influence of anti-inflammatory medication on exercise-induced myogenic precursor cell responses in humans

2007 ◽  
Vol 103 (2) ◽  
pp. 425-431 ◽  
Author(s):  
Abigail L. Mackey ◽  
Michael Kjaer ◽  
Sune Dandanell ◽  
Kristian H. Mikkelsen ◽  
Lars Holm ◽  
...  
Keyword(s):  
Satellite Cell ◽  
Cell Activity ◽  
Cell Number ◽  
Peak Oxygen Consumption ◽  
Neural Cell Adhesion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Exercise Induced ◽  
Muscle Biopsies ◽  
Satellite Cell Activity

The consumption of nonsteroidal anti-inflammatory drugs (NSAIDs) is widespread among athletes when faced with muscle soreness or injury, but the effects of NSAIDs on satellite cell activity in humans are unknown. To investigate this, 14 healthy male endurance athletes (mean peak oxygen consumption 62 ml·kg−1·min−1) volunteered for the study, which involved running 36 km. They were divided into two groups and received either 100 mg indomethacin per day or placebo. Muscle biopsies collected before the run and on days 1, 3, and 8 afterward were analyzed for satellite cells by immunohistochemistry with the aid of neural cell adhesion molecule (NCAM) and fetal antigen-1 (FA1) antibodies. Muscle biopsies were also collected from untrained individuals for comparison. Compared with preexercise levels, a 27% increase in the number of NCAM+ cells was observed on day 8 postexercise in the placebo group ( P < 0.05), while levels remained similar at all time points in the NSAID group. No change was seen in the proportion of FA1+ cells, although lower levels were found in the muscle of endurance-trained athletes compared with untrained individuals ( P < 0.05). These results suggest that ingestion of anti-inflammatory drugs attenuates the exercise-induced increase in satellite cell number, supporting the role of the cyclooxygenase pathway in satellite cell activity.

scholarly journals Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 501 ◽  
Author(s):  
Diego Fernández-Lázaro ◽  
Juan Mielgo-Ayuso ◽  
Jesús Seco Calvo ◽  
Alfredo Córdova Martínez ◽  
Alberto Caballero García ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Muscle Damage ◽  
Exercise Performance ◽  
Subjective Perception ◽  
Physically Active ◽  
Active Population ◽  
Oxidative Markers ◽  
Anti Inflammatory ◽  
Exercise Induced

Physical activity, particularly high-intensity eccentric muscle contractions, produces exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural polyphenol extracted from turmeric, has been shown to have mainly antioxidant and also anti-inflammatory properties. This effect of curcumin could improve EIMD and exercise performance. The main objective of this systematic review was to critically evaluate the effectiveness of curcumin supplementation on EIMD and inflammatory and oxidative markers in a physically active population. A structured search was carried out following Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines in the databases SCOPUS, Web of Science (WOS), and Medline (PubMed) from inception to October 2019. The search included original articles with randomized controlled crossover or parallel design in which the intake of curcumin administered before and/or after exercise was compared with an identical placebo situation. No filters were applied to the type of physical exercise performed, the sex or the age of the participants. Of the 301 articles identified in the search, 11 met the established criteria and were included in this systematic review. The methodological quality of the studies was assessed using the McMaster Critical Review Form. The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight antioxidant effect. In summary, the administration of curcumin at a dose between 150–1500 mg/day before and during exercise, and up until 72 h’ post-exercise, improved performance by reducing EIMD and modulating the inflammation caused by physical activity. In addition, humans appear to be able to tolerate high doses of curcumin without significant side-effects.

The Effect of Nonsteroidal Anti-Inflammatory Drugs on Recovery from Exercise-Induced Muscle Injury 1. Flurbiprofen

1998 ◽  
Vol 6 (4) ◽  
pp. 59-68 ◽  
Author(s):  
John N. Howell ◽  
Robert R. Conatser ◽  
Gary S. Chleboun ◽  
Daniel L. Karapondo ◽  
Anthony G. Chila
Keyword(s):  
Muscle Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Exercise Induced

scholarly journals Can Exercise-Induced Muscle Damage Be a Good Model for the Investigation of the Anti-Inflammatory Properties of Diet in Humans?

Biomedicines ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 36
Author(s):  
Spyridon Methenitis ◽  
Ioanna Stergiou ◽  
Smaragdi Antonopoulou ◽  
Tzortzis Nomikos
Keyword(s):  
Muscle Damage ◽  
Dietary Patterns ◽  
Inflammatory Responses ◽  
Low Grade ◽  
Inflammatory Stimuli ◽  
Methodological Approaches ◽  
Anti Inflammatory ◽  
Exercise Induced ◽  
Low Grade Inflammation ◽  
Inflammatory Effect

Subclinical, low-grade, inflammation is one of the main pathophysiological mechanisms underlying the majority of chronic and non-communicable diseases. Several methodological approaches have been applied for the assessment of the anti-inflammatory properties of nutrition, however, their impact in human body remains uncertain, because of the fact that the majority of the studies reporting anti-inflammatory effect of dietary patterns, have been performed under laboratory settings and/or in animal models. Thus, the extrapolation of these results to humans is risky. It is therefore obvious that the development of an inflammatory model in humans, by which we could induce inflammatory responses to humans in a regulated, specific, and non-harmful way, could greatly facilitate the estimation of the anti-inflammatory properties of diet in a more physiological way and mechanistically relevant way. We believe that exercise-induced muscle damage (EIMD) could serve as such a model, either in studies investigating the homeostatic responses of individuals under inflammatory stimuli or for the estimation of the anti-inflammatory or pro-inflammatory potential of dietary patterns, foods, supplements, nutrients, or phytochemicals. Thus, in this review we discuss the possibility of exercise-induced muscle damage being an inflammation model suitable for the assessment of the anti-inflammatory properties of diet in humans.

The Effect of Nonsteroidal Anti-Inflammatory Drugs on Recovery from Exercise-Induced Muscle Injury 2. Ibuprofen

1998 ◽  
Vol 6 (4) ◽  
pp. 69-83 ◽  
Author(s):  
John N. Howell ◽  
Robert R. Conatser ◽  
Gary S. Chleboun ◽  
Daniel L. Karapondo ◽  
Anthony G. Chila
Keyword(s):  
Muscle Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Exercise Induced

Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat

1994 ◽  
Vol 13 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Gary J. Chellman ◽  
Lance O. Lollini ◽  
Albert E. Dorr ◽  
Linval R. DePass
Keyword(s):  
Muscle Damage ◽  
Diclofenac Sodium ◽  
Isotonic Saline ◽  
The Other ◽  
Ketorolac Tromethamine ◽  
Clinical Use ◽  
Local Tolerance ◽  
Pain On Injection ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The local tolerance of ketorolac tromethamine (Toradol®, Syntex) was compared with that of four other injectable nonsteroidal anti-inflammatory drugs (NSAIDs) (diclofenac sodium, piroxicam, ketoprofen, and metamizol magnesium) in the rat paw-lick/muscle irritation assay as described previously,1 All drugs were tested at concentrations approved for clinical use. After subplantar (footpad) injection, ketorolac produced virtually no pain-on-injection as assessed by the number of paw-lick/lift responses during a 15 min observation period. The other NSAIDs produced slight to moderate paw-lick/lift responses. Redness and swelling at the injection site were less severe for ketorolac than for the other NSAIDs, After intramuscular (i.m.) injection, all of the. NSAIDs produced some degree of muscle damage, as assessed histopathologically 24 h after injection. The lesions, consisting primarily of muscle degeneration, were less severe for ketorolac than for the other NSAIDs. Ketorolac and metamizol produced the smallest elevations in serum creatine kinase, as measured 2 h after i.m. dosing, not significantly different from isotonic saline. Overall, ketorolac was better tolerated in the assay than the other injectable NSAIDs, thereby suggesting the possibility of improved local tolerance on clinical use.

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