Microwave-assisted Michael addition of sulfonamides to α,β-unsaturated esters: A rapid entry to protected β-amino acid synthesis

2007 ◽  
Vol 4 (4) ◽  
pp. 467-475 ◽  
Author(s):  
G. H. Imanzadeh ◽  
A. Zare ◽  
A. Khalafi-Nezhad ◽  
A. Hasaninejad ◽  
A. R. Moosavi Zare ◽  
...  
Keyword(s):  
Amino Acid ◽  
Michael Addition ◽  
Acid Synthesis ◽  
Amino Acid Synthesis ◽  
Unsaturated Esters ◽  
Microwave Assisted

Direct microwave-assisted amino acid synthesis by reaction of succinic acid and ammonia in the presence of magnetite

2013 ◽  
Vol 12 (4) ◽  
pp. 331-336 ◽  
Author(s):  
Nan Jiang ◽  
Dandan Liu ◽  
Weiguang Shi ◽  
Yingjie Hua ◽  
Chongtai Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Succinic Acid ◽  
Aspartic Acid ◽  
Acid Synthesis ◽  
Hydrothermal Systems ◽  
Catalyst Loading ◽  
Amino Acid Synthesis ◽  
Microwave Assisted ◽  
Direct Reactions ◽  
Hydrothermal Environments

AbstractSince the discovery of submarine hot vents in the late 1970s, it has been postulated that submarine hydrothermal environments would be suitable for emergence of life on Earth. To simulate warm spring conditions, we designed a series of microwave-assisted amino acid synthesis involving direct reactions between succinic acid and ammonia in the presence of the magnetite catalyst. These reactions which generated aspartic acid and glycine were carried out under mild temperatures and pressures (90–180 °C, 4–19 bar). We studied this specific reaction inasmuch as succinic acid and ammonia were traditionally identified as prebiotic compounds in primitive deep-sea hydrothermal systems on Earth. The experimental results were discussed in both biochemical and geochemical context to offer a possible route for abiotic amino acid synthesis. With extremely diluted starting materials (0.002 M carboxylic acid and 0.002 M ammonia) and catalyst loading, an obvious temperature dependency was observed in both cases [neither product was detected at 90 °C in comparison with 21.08 μmol L−1 (aspartic acid) and 70.25 umol L−1 (glycine) in 180 °C]. However, an opposite trend presented for reaction time factor, namely a positive correlation for glycine, but a negative one for aspartic acid.

scholarly journals Petasis vs. Strecker Amino Acid Synthesis: Convergence, Divergence and Opportunities in Organic Synthesis

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1707
Author(s):  
Wayiza Masamba
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Organic Synthesis ◽  
Acid Synthesis ◽  
Physical Sciences ◽  
Amino Acid Synthesis

α-Amino acids find widespread applications in various areas of life and physical sciences. Their syntheses are carried out by a multitude of protocols, of which Petasis and Strecker reactions have emerged as the most straightforward and most widely used. Both reactions are three-component reactions using the same starting materials, except the nucleophilic species. The differences and similarities between these two important reactions are highlighted in this review.

scholarly journals Enzymatic cascade systems for D-amino acid synthesis: progress and perspectives

2021 ◽  
Author(s):  
Anwen Fan ◽  
Jiarui Li ◽  
Yangqing Yu ◽  
Danping Zhang ◽  
Yao Nie ◽  
...  
Keyword(s):  
Amino Acid ◽  
Acid Synthesis ◽  
Amino Acid Synthesis ◽  
Cascade Systems

Reconstitution of amino acid synthesis by combining spinach chloroplasts with other leaf organelles

1979 ◽  
Vol 18 (7) ◽  
pp. 1109-1111 ◽  
Author(s):  
Barbara Buchholz ◽  
Brigitte Reupke ◽  
Horst Bickel ◽  
Gernot Schultz
Keyword(s):  
Amino Acid ◽  
Acid Synthesis ◽  
Amino Acid Synthesis ◽  
Spinach Chloroplasts

Enzymes for amino acid synthesis by design

2021 ◽  
Vol 4 (5) ◽  
pp. 348-349
Author(s):  
Christopher K. Prier
Keyword(s):  
Amino Acid ◽  
Acid Synthesis ◽  
Amino Acid Synthesis

Human Platelets: Amino Acid Synthesis

1969 ◽  
Vol 131 (3) ◽  
pp. 957-959 ◽  
Author(s):  
E. Puszkin ◽  
L. Aledort ◽  
S. Puszkin
Keyword(s):  
Amino Acid ◽  
Acid Synthesis ◽  
Human Platelets ◽  
Amino Acid Synthesis

A Quaternary Nitronyl Nitroxide α-Amino Acid: Synthesis, Configurational and Conformational Assignments, and Physicochemical Properties

2014 ◽  
Vol 2014 (8) ◽  
pp. 1741-1752 ◽  
Author(s):  
Karen Wright ◽  
Edouard d'Aboville ◽  
Joseph Scola ◽  
Tommaso Margola ◽  
Antonio Toffoletti ◽  
...  
Keyword(s):  
Amino Acid ◽  
Physicochemical Properties ◽  
Acid Synthesis ◽  
Nitronyl Nitroxide ◽  
Amino Acid Synthesis
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