The American Society for Mass Spectrometry

1996 ◽  
Vol 7 (9) ◽  
pp. 991-994
Keyword(s):  
Mass Spectrometry ◽  
American Society

scholarly journals Providing grants to attend scientific meetings

2002 ◽  
Vol 24 (4) ◽  
pp. 44
Keyword(s):  
Mass Spectrometry ◽  
Travel Grant ◽  
Scientific Meetings ◽  
American Society ◽  
Poster Presentations

The 50th ‘American Society for Mass Spectrometry and Allied Topics’ conference was held on 2–6 June in Orlando, Florida. The conference comprised of plenary sessions, oral and poster presentations, as well as exhibits and tutorials. With the aid of a Biochemical Society Travel Grant, Joanne Connelly went along and presented a poster.

scholarly journals On-line Monitoring of End-tidal Propofol Concentration in Anesthetized Patients

2007 ◽  
Vol 106 (4) ◽  
pp. 659-664 ◽  
Author(s):  
Akira Takita ◽  
Kenichi Masui ◽  
Tomiei Kazama
Keyword(s):  
Mass Spectrometry ◽  
Proton Transfer ◽  
Elective Surgery ◽  
Plasma Concentrations ◽  
Paired Data ◽  
Data Points ◽  
On Line ◽  
American Society ◽  
End Tidal ◽  
American Society Of Anesthesiologists

Background Propofol (2,6-diisopropylphenol) has some volatility, so it can be detected in expired breath of individuals receiving intravenous propofol. This study measured volatile propofol exhaled by patients and investigated the relation between exhaled and plasma propofol concentrations. Methods Nineteen patients with American Society of Anesthesiologists physical status I or II who were undergoing elective surgery participated in this two-part study. In study 1 (n = 11), anesthesia was induced with 2 mg/kg propofol, 0.1 mg/kg vecuronium, and 2 microg/kg fentanyl. After intubation, propofol was administered continuously for 60 min at each of three rates: 3, 6, and 9 mg x kg(-1) x h(-1). Blood samples were obtained just before each change in the infusion rate, and the plasma concentrations of propofol were measured. The exhaled propofol concentration was measured continuously by means of proton transfer mass spectrometry. End-tidal propofol concentrations during blood sampling were averaged and compared with plasma propofol concentrations. In study 2 (n = 8), after induction of anesthesia, patients received a bolus injection of 2 mg/kg propofol, and the exhaled propofol concentration was measured. Results Volatile propofol was detected in expired gas from all study patients. From study 1, the authors obtained 24 paired data points, i.e., concentrations of end-tidal and plasma propofol. With Bland-Altman analysis, bias +/- precision was 5.2 +/- 10.4 with 95% limits of agreement of -15.1 and 25.6. In study 2, the exhaled propofol concentration curve showed an obvious peak in all patients. Conclusions Agreement between plasma and exhaled propofol concentrations suggests that proton transfer mass spectrometry can be used for real-time propofol monitoring.

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