Pharmacokinetics of etoposide in rats with uranyl nitrate (UN)-induced acute renal failure (ARF): Optimization of the duration of UN dosing

2007 ◽  
Vol 32 (4) ◽  
pp. 189-196 ◽  
Author(s):  
P. Venkatesh ◽  
T. Harisudhan ◽  
Hira Choudhury ◽  
Ramesh Mullangi ◽  
Nuggehally R. Srinivas
Nephron ◽  
1987 ◽  
Vol 45 (4) ◽  
pp. 296-301 ◽  
Author(s):  
Peter M. Andrews ◽  
Sally B. Bates

2012 ◽  
Vol 64 (10) ◽  
pp. 1452-1460 ◽  
Author(s):  
Seung Yon Han ◽  
Si Hyung Yang ◽  
Insoo Yoon ◽  
Myung Gull Lee ◽  
Young Hee Choi

2001 ◽  
Vol 45 (12) ◽  
pp. 3607-3609 ◽  
Author(s):  
Antoine Dupuis ◽  
Anne Limosin ◽  
Joël Paquereau ◽  
Olivier Mimoz ◽  
William Couet ◽  
...  

ABSTRACT The epileptogenic activity of imipenem was investigated in rats with experimental renal failure induced by uranyl nitrate injection by using electroencephalogram (EEG) recording and a pharmacokinetic-pharmacodynamic model including an effect compartment. Results previously obtained with healthy rats were used to estimate the dose of imipenem required to induce an observable but nonlethal EEG effect on the assumption that only the pharmacokinetic parameters of the model would be affected by renal failure. Good agreement was observed between the predicted and observed effects.


1972 ◽  
Vol 31 (5) ◽  
pp. 682-698 ◽  
Author(s):  
WALTER FLAMENBAUM ◽  
JAMES S. MCNEIL ◽  
THEODORE A. KOTCHEN ◽  
ANDREW J. SALADINO

2003 ◽  
Vol 92 (8) ◽  
pp. 1604-1613 ◽  
Author(s):  
Choong Y. Ahn ◽  
Eun J. Kim ◽  
Inchul Lee ◽  
Jong W. Kwon ◽  
Won B. Kim ◽  
...  

1977 ◽  
Vol 12 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Jack G. Kleinman ◽  
James S. McNeil ◽  
John H. Schwartz ◽  
Robert J. Hamburger ◽  
Walter Flamenbaum

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