Bioavailability and hypoglycemic activity of the semisynthetic bile acid salt, sodium 3α,7α-dihydroxy-12-0X0-5β-cholanate, in healthy and diabetic rats

2007 ◽  
Vol 32 (1) ◽  
pp. 7-12 ◽  
Author(s):  
M. Mikov ◽  
N. S. Boni ◽  
H. Al-Salami ◽  
K. Kuhajda ◽  
S. Kevresan ◽  
...  
Keyword(s):  
Bile Acid ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Acid Salt

Comparison of Hypoglycemic and Antioxidant Activities of the Compounds Isolated from Ficus hispida Linn. and Ficus pomifera Wall

2020 ◽  
Vol 10 (5) ◽  
pp. 621-630
Author(s):  
Ashalata Nepram ◽  
Sujata Wangkheirakpam ◽  
Warjeet S. Laitonjam
Keyword(s):  
Methanol Extract ◽  
Antioxidant Activities ◽  
Tolerance Test ◽  
Chloroform Extract ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
North East India ◽  
North East ◽  
Dpph Method ◽  
Ficus Hispida

Background: Traditional knowledge has been a legacy of the past to the present. Barks of Ficus hispida Linn. and leaves of Ficus pomifera Wall. (Moraceae) have been used traditionally for the treatment of diabetes in North-east India and many other places. As many drugs have been developed from traditional plants, the authors have taken up the plants for the study of hypoglycemic activity. Objective: To investigate the hypoglycemic activities of the triterpenoids isolated from the plants and their antioxidant activities. Methods: The bioactive compounds were determined by biochemical analysis, antioxidant activity using DPPH method. Hypoglycemic activity was detected using glucose tolerance test in normal rats and alloxan induced diabetic rats with Gliclazide as standard. Results: The biochemicals and trace elements were present in appreciable amounts. Triterpenoids, (1-5), from F. pomifera and 19-hydroxyphlogacantholide (6), 3-O-[ß-D-glucopyranosyl-(1’→2’)-α- L-rhamnopyranosyl-phlogacanthoside] (7) and galanolactone (8) along with stigmasterol (9), stigmasta- 5,22-dien-7-on-3ß-ol (10), 5-(decahydro-1,1,4a-trimethyl-6-methylene-5-yl)-3-methylpent-2- enal (11), stigmasterol glucoside (12) and stigmast-4-en-3-one (13) from F. hispida Linn., respectively, were isolated. The different extracts of the barks and leaves of these plants along with the isolated compounds had antioxidant and hyploglycemic activities. Conclusions: The five triterpenoids (1-5) were isolated from the methanol extract of the leaves of F. pomifera, and compounds (6-13) were isolated from the chloroform extract of the barks of F. hispida. Methanol extract of the leaves of F. pomifera and the chloroform extract of the barks of F. hispida; compounds (1-13) isolated from these two plants reduced DPPH free radicals in a concentrationdependent manner. It was also observed that the methanol and chloroform extracts of the plants, F. pomifera and F. hispida respectively, and the compounds (1, 6 & 7) exhibited anti-diabetic properties and also caused a highly significant reduction in the blood glucose levels of normal rats.

scholarly journals Design and Synthesis of Pyrazole-3-one Derivatives as Hypoglycaemic Agents

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Prasanna A. Datar ◽  
Sonali R. Jadhav
Keyword(s):  
Amino Acid ◽  
Docking Studies ◽  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Amino Acid Residues ◽  
Docking Score ◽  
Design And Synthesis ◽  
Hypoglycaemic Agents ◽  
Standard Compound

Pyrazole-3-one compounds were designed on the basis of docking studies of previously reported antidiabetic pyrazole compounds. The amino acid residues found during docking studies were used as guidelines for the modification of aromatic substitutions on pyrazole-3-one structure. Depending on the docking score, the designed compounds were selectively prioritized for synthesis. The synthesized compounds were subjected to in vivo hypoglycemic activity using alloxan induced diabetic rats and metformin as a standard. Compound 4 having sulphonamide derivative was found to be the most potent compound among the series.

scholarly journals Long-Term Acting and Orally Active Vanadyl-Methylpicolinate Complex with Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats.

1997 ◽  
Vol 23 (2) ◽  
pp. 113-129 ◽  
Author(s):  
Seiki FUJIMOTO ◽  
Kumiko FUJII ◽  
Hiroyuki YASUI ◽  
Rokuji MATSUSHITA ◽  
Jitsuya TAKADA ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Orally Active

Effects of Diet on Bile Acid Metabolism and Insulin Resistance in Type 2 Diabetic Rats after Roux-en-Y Gastric Bypass

2018 ◽  
Vol 28 (10) ◽  
pp. 3044-3053 ◽  
Author(s):  
Cheng-Xiang Shan ◽  
Nian-Cun Qiu ◽  
Miao-E Liu ◽  
Si-Luo Zha ◽  
Xin Song ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gastric Bypass ◽  
Bile Acid ◽  
Acid Metabolism ◽  
Diabetic Rats ◽  
Bile Acid Metabolism ◽  
Type 2 Diabetic
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