Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine; comparison to the liver

2003 ◽  
Vol 28 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Monica Lindell ◽  
Matti Lang ◽  
Hans Lennernäs
Keyword(s):  
Cytochrome P450 ◽  
Small Intestine ◽  
Rat Small Intestine ◽  
Cytochrome P450 Enzymes ◽  
P Glycoprotein ◽  
Expression Of Genes ◽  
Genes Encoding

Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system

2000 ◽  
Vol 11 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Akira Nakayama ◽  
Hiroshi Saitoh ◽  
Masako Oda ◽  
Masahiko Takada ◽  
Bruce J Aungst
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
Efflux System ◽  
P Glycoprotein

scholarly journals No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P‐glycoprotein

2019 ◽  
Vol 106 (2) ◽  
pp. 432-440 ◽  
Author(s):  
Catherine Zahner ◽  
Esther Kruttschnitt ◽  
Julia Uricher ◽  
Michael Lissy ◽  
Martin Hirsch ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
St John’S Wort ◽  
St John's Wort ◽  
P Glycoprotein

Disruption of cytochrome P450 enzymes in the liver and small intestine in chicken embryos in ovo exposed to glyphosate

2020 ◽  
Vol 27 (14) ◽  
pp. 16865-16875 ◽  
Author(s):  
Mohamed Ahmed Fathi ◽  
Guofeng Han ◽  
Ruifen Kang ◽  
Dan Shen ◽  
Jiakun Shen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Small Intestine ◽  
Cytochrome P450 Enzymes ◽  
In Ovo ◽  
Chicken Embryos

scholarly journals Different Absorption Behaviors among Steriod Hormones Due to Possible Interaction with P-Glycoprotein in the Rat Small Intestine.

1999 ◽  
Vol 22 (5) ◽  
pp. 535-538 ◽  
Author(s):  
Akira NAKAYAMA ◽  
Orie EGUCHI ◽  
Masataka HATAKEYAMA ◽  
Hiroshi SAITOH ◽  
Masahiko TAKADA
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
P Glycoprotein

Characterization of the Cytochrome P450 CYP2J4: Expression in Rat Small Intestine and Role in Retinoic Acid Biotransformation from Retinal

1998 ◽  
Vol 353 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Qing-Yu Zhang ◽  
Gregory Raner ◽  
Xinxin Ding ◽  
Deborah Dunbar ◽  
Minor J. Coon ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Small Intestine ◽  
Retinoic Acid ◽  
Rat Small Intestine

scholarly journals Expression of Genes Related to Carrageenan Synthesis during Carposporogenesis of the Red Seaweed Grateloupia imbricata

Marine Drugs ◽  
2020 ◽  
Vol 18 (9) ◽  
pp. 432
Author(s):  
Pilar Garcia-Jimenez ◽  
Sara R. Mantesa ◽  
Rafael R. Robaina
Keyword(s):  
Cytochrome P450 ◽  
Stress Proteins ◽  
Life Cycles ◽  
Raw Material ◽  
Red Seaweed ◽  
Red Seaweeds ◽  
Temporal Regulation ◽  
Expression Of Genes ◽  
Genes Encoding ◽  
Two Stages

Carrageenan, the foremost constituent of extracellular matrix of some rhodophyta, is a galactan backbone with a different number of sulphate groups attached. Variations of degree of sulphation are associated with different types of carrageenans, which vary according to seaweed life cycles, and have consequences for the exploitation of this raw material. In this work, we used three well-recognised stages of development thalli and two stages of cystocarp maturation to analyse genes that encode addition and elimination of sulphate groups to cell-wall galactan of the red seaweed Grateloupia imbricata. Expressions of carbohydrate sulfotransferase and galactose-6 sulfurylase and genes encoding stress proteins such as cytochrome P450 and WD40, were examined. Results showed that transcript expression of carbohydrate sulfotransferase occurs at all stage of thalli development. Meanwhile galactose-6 sulfurylase expressions displayed different roles, which could be related to a temporal regulation of cystocarp maturation. Cytochrome P450 and WD40 are related to the disclosure and maturation of cystocarps of G. imbricata. Our conclusion is that differential expression of genes encoding proteins involved in the sulphation and desulphation of galactan backbone is associated with alterations in thalli development and cystocarp maturation in the red seaweed Grateloupia imbricata. Exploitation of industry-valued carrageenan will depend on insight into gene mechanisms of red seaweeds.

scholarly journals In Vitro Inhibitory Effects of Scutellarin on Six Human/Rat Cytochrome P450 Enzymes and P-glycoprotein

Molecules ◽  
2014 ◽  
Vol 19 (5) ◽  
pp. 5748-5760 ◽  
Author(s):  
Yong-Long Han ◽  
Dan Li ◽  
Quan-Jun Yang ◽  
Zhi-Yong Zhou ◽  
Li-Ya Liu ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
P Glycoprotein
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