Pharmacokinetics of triflusal and its main metabolite HTB in healthy subjects following a single oral dose

1991 ◽  
Vol 16 (4) ◽  
pp. 269-273 ◽  
Author(s):  
J. Ramis ◽  
R. Mis ◽  
J. Forn ◽  
J. Torrent ◽  
E. Gorina ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects ◽  
Main Metabolite

scholarly journals Sparfloxacin Distribution in Human Saliva

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Kolaci M ◽  
Deda L
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects ◽  
Human Saliva

Aim: The aim of this study is to assess the penetration of sparfloxacin in mixed human saliva after a single oral dose of 400mg in Caucasian healthy subjects.

Absorption; metabolism and excretion of a single oral dose of 14c-paliperidone 1mg in healthy subjects (PAL-053)

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
M Vermeir ◽  
S Boom ◽  
I Naessens ◽  
K Talluri ◽  
M Eerdekens ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects

Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects

2020 ◽  
Vol 85 (5) ◽  
pp. 899-906 ◽  
Author(s):  
Ken Ogasawara ◽  
Christine Xu ◽  
Vanaja Kanamaluru ◽  
Maria Palmisano ◽  
Gopal Krishna
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Subjects ◽  
Oral Doses

Effects of Cloprednol and other Corticosteroids on Hypothalamic-Pituitary-Adrenal Axis Function

1976 ◽  
Vol 4 (5) ◽  
pp. 326-337 ◽  
Author(s):  
Eduardo Ortega ◽  
Consuelo Rodriguez ◽  
L James Strand ◽  
Eugene Segre
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Hpa Axis ◽  
Healthy Subjects ◽  
Plasma Cortisol ◽  
Cortisol Response ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis ◽  
Hpa Function

The effects of cloprednol and other synthetic corticosteroids on hypothalamic-pituitary-adrenal (HPA) function were studied in healthy subjects after administration of a single oral dose of corticosteroid at 6 a.m. or 6 p.m., and after daily 6 a.m. administration of corticosteroids at various doses for seven days. The degree of HPA suppression was assessed by metyrapone tests (METP), insulin hypoglycaemia tests (IHT) and 6 a.m. fasting plasma Cortisol concentrations. Regardless of the corticosteroid tested, 6 p.m. dosing was at least four-fold more suppressive of METP response than 6 a.m. administration. At therapeutically equivalent doses, single doses of triamcinolone and dexamethasone were more suppressive of HPA-axis function than cloprednol, hydrocortisone or prednisolone. After 6 a.m. administration for seven days, 12·5 mg of cloprednol did not impair the Cortisol response to IHT or interfere with the METP response. The clinically equivalent dose of prednisolone (25 mg) resulted in slightly greater HPA-axis suppression. All doses of dexamethasone (0·5, 3·75 and 6·0 mg) and of betamethasone (2·0, 4·0 and 6·5 mg) were more suppressive of HPA-axis function than either cloprednol or prednisolone. These results suggest that at equipotent anti-inflammatory doses, cloprednol is slightly less suppressive of HPA-axis function than prednisolone, and both cloprednol and prednisolone are much less suppressive than dexamethasone or betamethasone.

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