Nonlinear binding of sex steroids to albumin and sex hormone binding globulin

1997 ◽  
Vol 22 (3) ◽  
pp. 229-235 ◽  
Author(s):  
T. Zeginiadou ◽  
S. Kolias ◽  
D. Kouretas ◽  
O. Antonoglou
Keyword(s):  
Sex Steroids ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Nonlinear Binding

scholarly journals Sex Hormone-Binding Globulin in Fish Gills Is a Portal for Sex Steroids Breached by Xenobiotics

Endocrinology ◽  
2008 ◽  
Vol 149 (9) ◽  
pp. 4269-4275 ◽  
Author(s):  
Solange Miguel-Queralt ◽  
Geoffrey L. Hammond
Keyword(s):  
Sex Steroids ◽  
Dynamic Range ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sex Steroid ◽  
Zebra Fish ◽  
Hormone Binding ◽  
Fish Gills ◽  
Specialized Function ◽  
Synthetic Steroids

As in most vertebrates, plasma sex hormone-binding globulin (SHBG) is produced in fish liver and regulates sex steroid access to target tissues. Low levels of SHBG mRNA are present in zebra fish gills but are unlikely to account for the high amounts of immunoreactive SHBG in filaments and lamellae. Although the uptake of steroids by fish from water has been reported to correlate with their affinity for SHBG, it is not known how this occurs. Our studies of zebra fish SHBG have revealed its preference for biological active androgen (testosterone), as well as for androstenedione, a sex steroid precursor that also acts as a pheromone in some fish. In addition to natural steroids, zebra fish SHBG has a high affinity for synthetic steroids, such as ethinylestradiol and progestins (levonorgestrel and norethindrone), that are present in waste water systems. Because steroids can pass across fish gills, we examined whether SHBG serves as a portal for natural and synthetic steroids controlling their flux between the blood and aquatic environment. The results indicate that SHBG ligands are rapidly and specifically removed from water by the fish through their gills, whereas the accumulated steroids are released slowly. The capacity of fish to sequester SHBG ligands from water is similar between sexes, independent of size, and characterized by a wide dynamic range. We conclude that SHBG controls the flux of sex steroids across fish gills and that this highly specialized function can be hijacked by xenobiotic ligands of fish SHBGs.

scholarly journals Sex Steroids, Sex Hormone-Binding Globulin and Cardiovascular Health in Men and Postmenopausal Women: The Rotterdam Study

2016 ◽  
Vol 101 (7) ◽  
pp. 2844-2852 ◽  
Author(s):  
Loes Jaspers ◽  
Klodian Dhana ◽  
Taulant Muka ◽  
Cindy Meun ◽  
Jessica C. Kiefte-de Jong ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Sex Steroids ◽  
Cardiovascular Health ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Rotterdam Study ◽  
Hormone Binding

scholarly journals Serum sex steroids, gonadotrophins and sex hormone-binding globulin in prostatic hyperplasia

2008 ◽  
Vol 28 (3) ◽  
pp. 174-178
Author(s):  
Mohammad Abdul Jalil Ansari ◽  
Dilruba Begum ◽  
Fakhrul Islam
Keyword(s):  
Sex Steroids ◽  
Prostatic Hyperplasia ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

The influence of luteinizing hormone and insulin on sex steroids and sex hormone-binding globulin in the polycystic ovarian syndrome*

1993 ◽  
Vol 60 (4) ◽  
pp. 626-633 ◽  
Author(s):  
Richard P. Buyalos ◽  
Mitchell E. Geffner ◽  
Richard M. Watanabe ◽  
Richard N. Bergman ◽  
Jeffrey A. Gornbein ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Sex Steroids ◽  
Polycystic Ovarian Syndrome ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Ovarian Syndrome

Sex steroids and sex-hormone binding globulin in males with chronic alcoholism

2008 ◽  
Vol 8 (5) ◽  
pp. 273-276 ◽  
Author(s):  
J. LINDHOLM ◽  
N. FABRICIUS-BJERRE ◽  
M. BAHNSEN ◽  
P. BOIESEN ◽  
C. HAGEN ◽  
...  
Keyword(s):  
Sex Steroids ◽  
Chronic Alcoholism ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Desialylated sex hormone-binding globulin (D-SHBG) in chronic liver diseases: a possible vector of sex steroids in hepatocytes

1998 ◽  
Vol 28 ◽  
pp. 176
Author(s):  
L. Rakotomalala ◽  
M. Pontet ◽  
N. Ganne-Carrié ◽  
J. Vaysse ◽  
C. Christidis ◽  
...  
Keyword(s):  
Sex Steroids ◽  
Liver Diseases ◽  
Sex Hormone ◽  
Chronic Liver ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Chronic Liver Diseases
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