Food effect on the oral bioavailability of Manidipine: single dose, randomized, crossover study in healthy male subjects

1998 ◽  
Vol 23 (2) ◽  
pp. 197-202 ◽  
Author(s):  
D. Rosillon ◽  
A. Stockis ◽  
G. Poli ◽  
D. Acerbi ◽  
R. Lins ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Oral Bioavailability ◽  
Food Effect ◽  
Healthy Male ◽  
Male Subjects ◽  
Randomized Crossover Study

scholarly journals Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Patcharanee Tawasri ◽  
Chadarat Ampasavate ◽  
Somsak Tharatha ◽  
Natthakarn Chiranthanut ◽  
Supanimit Teekachunhatean
Keyword(s):  
Ascorbic Acid ◽  
Single Dose ◽  
Plasma Concentration ◽  
Crossover Study ◽  
Biologically Active ◽  
Pharmacokinetic Parameters ◽  
Healthy Male ◽  
Ganoderic Acid ◽  
To Receive ◽  
Male Subjects

The objective of this randomized, open-label, single-dose, two-phase crossover study was to determine the effect of ascorbic acid on pharmacokinetics of ganoderic acid A, an important biologically active triterpenoid compound with anticancer activities, following oral administration of water extract of fruiting bodies of Ling Zhi in 12 healthy male subjects. Each subject was randomized to receive either one of the two regimens: (1) a single dose of 3,000 mg of the Ling Zhi preparation or (2) a single dose of 3,000 mg of the Ling Zhi preparation in combination with 2,500 mg of ascorbic acid. After a washout period of at least two weeks, subjects were switched to receive the alternate regimen. Blood samples were collected in each phase immediately before dosing and at specific time points for 8 hours after dosing. Plasma ganoderic acid A concentrations were quantified using liquid chromatography-mass spectrometry (LC-MS). The pharmacokinetic parameters analyzed were maximal plasma concentration (Cmax), time to reach peak concentration (Tmax), area under the plasma concentration-time curve (AUC), and half-life (t1/2). An oral coadministration of ascorbic acid with Ling Zhi preparation did not significantly alter the pharmacokinetic parameters of ganoderic acid A in healthy male subjects.

Bioavailability of Digoxin and Beta-Methyl-Digoxin

1976 ◽  
Vol 4 (5) ◽  
pp. 352-354
Author(s):  
L Padeletti ◽  
F Fantini ◽  
P Cinelli ◽  
C Gremigni
Keyword(s):  
Single Dose ◽  
Serum Concentration ◽  
Urinary Excretion ◽  
Crossover Study ◽  
Drug Absorption ◽  
Normal Volunteers ◽  
Cumulative Urinary Excretion ◽  
Serial Serum ◽  
Concentration Measurements ◽  
Randomized Crossover Study

In a randomized crossover study the bioavailability of a single dose of digoxin and of beta-methyl-digoxin tablets was tested in four normal volunteers. No difference was found between the two products in the rate and extent of drug absorption using 6 day cumulative urinary excretion and serial serum concentration measurements.

Single-Dose Comparative Pharmacokinetics of Two Formulations of Lenalidomide 25 mg in Healthy Subjects: A Randomized Crossover Study

2018 ◽  
Vol 35 (2) ◽  
pp. 210-217
Author(s):  
SeungHwan Lee ◽  
Jun Gi Hwang ◽  
Sang Yeob Park ◽  
Hye Jung Lim ◽  
Sa-Won Lee ◽  
...  
Keyword(s):  
Single Dose ◽  
Crossover Study ◽  
Healthy Subjects ◽  
Randomized Crossover Study

scholarly journals Pharmacokinetics, Pharmacodynamics and Safety of a Single Dose of Imarikiren, a Novel Renin Inhibitor, in Healthy Male Subjects

2018 ◽  
Vol 123 (5) ◽  
pp. 607-614 ◽  
Author(s):  
Kumi Matsuno ◽  
Shingo Kuroda ◽  
Shingo Tanaka ◽  
Hiroyuki Nakamichi ◽  
Tomoya Kagawa ◽  
...  
Keyword(s):  
Single Dose ◽  
Renin Inhibitor ◽  
Healthy Male ◽  
Male Subjects
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