scholarly journals Two-dimensional and three-dimensional imaging of the in vivo lung: Combining spiral computed tomogrpahy with multiplanar and volumetric rendering techniques

1994 ◽  
Vol 7 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Janet E. Kuhlman ◽  
Derek R. Ney ◽  
Elliot K. Fishman
Radiology ◽  
1987 ◽  
Vol 163 (3) ◽  
pp. 737-738 ◽  
Author(s):  
E K Fishman ◽  
B Drebin ◽  
D Magid ◽  
W W Scott ◽  
D R Ney ◽  
...  

2012 ◽  
Vol 9 (77) ◽  
pp. 3288-3302 ◽  
Author(s):  
Neha Arya ◽  
Viren Sardana ◽  
Meera Saxena ◽  
Annapoorni Rangarajan ◽  
Dhirendra S. Katti

Owing to the reduced co-relationship between conventional flat Petri dish culture (two-dimensional) and the tumour microenvironment, there has been a shift towards three-dimensional culture systems that show an improved analogy to the same. In this work, an extracellular matrix (ECM)-mimicking three-dimensional scaffold based on chitosan and gelatin was fabricated and explored for its potential as a tumour model for lung cancer. It was demonstrated that the chitosan–gelatin (CG) scaffolds supported the formation of tumoroids that were similar to tumours grown in vivo for factors involved in tumour-cell–ECM interaction, invasion and metastasis, and response to anti-cancer drugs. On the other hand, the two-dimensional Petri dish surfaces did not demonstrate gene-expression profiles similar to tumours grown in vivo . Further, the three-dimensional CG scaffolds supported the formation of tumoroids, using other types of cancer cells such as breast, cervix and bone, indicating a possible wider potential for in vitro tumoroid generation. Overall, the results demonstrated that CG scaffolds can be an improved in vitro tool to study cancer progression and drug screening for solid tumours.


2018 ◽  
Vol 6 (4) ◽  
pp. 113
Author(s):  
SManoj Kumar ◽  
Hazza Al Hobeira ◽  
MohammadD Aljanakh ◽  
Sameer Shaikh ◽  
Kurian Ponnuse ◽  
...  

2006 ◽  
Vol 11 (3) ◽  
pp. 034032 ◽  
Author(s):  
Jung-Taek Oh ◽  
Meng-Lin Li ◽  
Hao F. Zhang ◽  
Konstantin Maslov ◽  
George Stoica ◽  
...  

2013 ◽  
Vol 45 (10) ◽  
pp. 628-632 ◽  
Author(s):  
Gangjun Liu ◽  
Wangcun Jia ◽  
J. Stuart Nelson ◽  
Zhongping Chen

Reproduction ◽  
2003 ◽  
pp. 259-270 ◽  
Author(s):  
DM Woolley

The hydrodynamic basis for the accumulation of spermatozoa at surfaces has been investigated. The general conclusion is that when spermatozoa arrive at a surface, they will remain there if the vector of the time-averaged thrust is directed towards that surface. This can arise in two basic ways. First, consider spermatozoa that maintain a three-dimensional waveform and roll (spin) as they progress: in this case, it is argued that the conical (rather than cylindrical) shape of the flagellar envelope will establish the direction-of-thrust necessary for capture by the surface. (Additional findings, for spermatozoa of this type, are that the swim-trajectory is curved and that the direction of its curvature reveals the roll-direction of the cell.) Second, consider spermatozoa that maintain a strictly two-dimensional waveform at the surface: in this case, spermatozoa can be captured because the plane-of-flattening of the sperm head is tilted slightly relative to the plane of the flagellar beat. The sperm head is acting as a hydrofoil and, in one orientation only, it comes to exert a pressure against the surface. (This pressure may possibly, in vivo, aid the penetration of the zona pellucida.) The hydrofoil action of sperm heads may explain any bias in the circling direction of spermatozoa that execute two-dimensional waves at surfaces. Finally, a more complex phenomenon is where interaction of the spermatozoa with the surface appears to induce a three-dimensional to two-dimensional conversion of the flagellar wave (thus permitting the hydrofoil effect described). This is characteristic of sperm with 'twisted planar' rather than helical waves. In mammalian spermatozoa, approximately half the beat cycle is planar and the other half generates a pattern of torque causing the head to roll clockwise (seen from ahead), producing a torsion of the neck region of the flagellum. It is the gradual suppression of this torsion, by either impedance at the solid boundary or by raised viscosity, that converts the 'twisted planar' shape into a planar wave.


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