Changes in ECG and enzyme activity in rat heart after myocardial infarction: effect of TPP and MnCl2

2008 ◽  
Vol 64 (2) ◽  
pp. 93-101 ◽  
Author(s):  
A. Tylicki ◽  
J. Czerniecki ◽  
A. Godlewska ◽  
M. Kieliszek ◽  
T. Zebrowski ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Enzyme Activity ◽  
Rat Heart

Central haemodynamics in acute myocardial infarction in relation to mortality and peak enzyme activity

1986 ◽  
Vol 7 (6) ◽  
pp. 475-481 ◽  
Author(s):  
P. H. HELD ◽  
H. M. A. CORBEU ◽  
P. DUNSELMAN ◽  
Å. HJALMARSON ◽  
D. MURRAY ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Enzyme Activity

Differential effects of PI3K/Akt inhibition on myocardial infarction and arrhythmias in the rat heart

2006 ◽  
Vol 40 (6) ◽  
pp. 978
Author(s):  
Táňa Ravingerová ◽  
Janka Matejíková ◽  
Monika Strnisková ◽  
Jan Neckář ◽  
Eva Andelová ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Rat Heart ◽  
Differential Effects

Changes in mass and catalytic activity concentrations of aspartate aminotransferase isoenzymes in serum after a myocardial infarction.

1986 ◽  
Vol 32 (3) ◽  
pp. 496-500 ◽  
Author(s):  
A E Niblock ◽  
G Jablonsky ◽  
F Y Leung ◽  
A R Henderson
Keyword(s):  
Myocardial Infarction ◽  
Enzyme Activity ◽  
Catalytic Activity ◽  
Aspartate Aminotransferase ◽  
Left Ventricular ◽  
Peak Activity ◽  
Ventricular Failure ◽  
Total Enzyme Activity ◽  
Activity Concentrations ◽  
Total Enzyme

Abstract We used an RIA and inhibition of enzyme activity to monitor the changes in mass and catalytic concentrations of the aspartate aminotransferase (EC 2.6.1.1;AST) isoenzymes in serum after myocardial infarction. Cytosolic (c-AST) and mitochondrial (m-AST) forms of AST were present in sera from all 38 of our patients. Although the immunological and catalytic concentrations of both isoenzymes correlated well with the size of the infarct, c-AST gave a better measure than did m-AST. About 20% of the total enzyme activity at peak activity was from the mitochondrial isoenzyme. Both isoenzyme activities peak at very nearly the same time, but m-AST has the longer half-life. Immunological evidence of the mitochondrial isoenzyme can be detected in serum for at least eight days after the infarct. The presence of left ventricular failure produces greater serum isoenzyme activities than in those without failure.

Relationship between Serum Enzyme Activity in Acute Myocardial Infarction and Morbidity during a 2-Year Follow-Up

Cardiology ◽  
1986 ◽  
Vol 73 (2) ◽  
pp. 85-93 ◽  
Author(s):  
J. Herlitz ◽  
I. Helgesson ◽  
B.M. Hjalmarson ◽  
Å. Hjalmarson ◽  
C. Jonsteg ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Enzyme Activity ◽  
Serum Enzyme ◽  
Serum Enzyme Activity

P2499Effects of aerobic and resistance exercise on skeletal muscle of infarcted rats

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M J Gomes ◽  
A R R Lima ◽  
L U Pagan ◽  
F C Damatto ◽  
L R S Oliveira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Skeletal Muscle ◽  
Enzyme Activity ◽  
Glutathione Peroxidase ◽  
Resistance Exercise ◽  
Lipid Hydroperoxide ◽  
The Other ◽  
Species Production ◽  
Hydroperoxide Concentration

Abstract Background Skeletal muscle changes contribute to reduced physical performance after myocardial infarction (MI). Exercise has been recommended to stable patients. However, the effects of resistance exercise after MI are not clear. We compared the effects of aerobic and resistance exercise initiated during compensated cardiac remodeling in infarcted rat gastrocnemius muscle. Methods Three months after MI induction, Wistar rats were divided into four groups: Sham (n=20); sedentary MI (MI-S, n=9); aerobic exercised MI (MI-A, n=9); and resistance exercised MI (MI-R, n=13). Exercised rats trained three times a week for 12 weeks on a treadmill or ladder. Energy metabolism, oxidative stress markers, and antioxidant enzyme activities were assessed by spectrophotometry. Satellite cells activation markers (MyoD, NCAM, and myosin heavy chain neonatal isoform) were assessed by immunofluorescence or Western blot (Pax-7). Statistical analysis: ANOVA or Mann Whitney. Results Physical aerobic capacity was greater in MI-A and strength gain higher in MI-R. Cardiac structures and left ventricular function evaluated by echocardiogram did not differ between infarcted groups. Histological analysis showed that MI size and gastrocnemius cross sectional area did not differ between infarcted groups. Oxygen reactive species production was higher in MI-S than Sham and lipid hydroperoxide concentration was lower in MI-A than the other groups. Catalase activity was higher and glutathione peroxidase lower in infarcted groups than Sham. Superoxide dismutase activity was higher in Sham and MI-R than MI-S. Skeletal muscle metabolism enzyme activity did not differ between groups, except for increase pyruvate kinase in MI-S against the other groups, and β-hydroxyacyl CoA dehydrogenase in MI-S against Sham. Satellite cell activation and protein expression of MAPK and NF-kB did not differ between groups. Conclusion Aerobic and resistance exercise respectively improves physical capacity and muscle strength without changing echocardiographic parameters of infarcted rats. Myocardial infarction increases oxygen reactive species production and changes antioxidant enzyme activity and glucose and fatty acid metabolism. Aerobic exercise is superior to resistance exercise against oxidative stress reducing muscle lipid hydroperoxide concentration and attenuating change in glutathione peroxidase activity. Acknowledgement/Funding Financial support: Fapesp, CNPq, Capes, and UNESP

Cardiac repair using chitosan-hyaluronan/silk fibroin patches in a rat heart model with myocardial infarction

2013 ◽  
Vol 92 (1) ◽  
pp. 591-597 ◽  
Author(s):  
Nai-Hsin Chi ◽  
Ming-Chia Yang ◽  
Tze-Wen Chung ◽  
Nai-Kuan Chou ◽  
Shoei-Shen Wang
Keyword(s):  
Myocardial Infarction ◽  
Silk Fibroin ◽  
Rat Heart ◽  
Cardiac Repair ◽  
Heart Model
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