Brain tumor accumulation and plasma pharmacokinetic parameters of 2′-deoxy-5-18F-fluorouridine

1993 ◽  
Vol 7 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Kiichi Ishiwata ◽  
Yuji Tsurumi ◽  
Motonobu Kameyama ◽  
Kiyotaka Sato ◽  
Ren Iwata ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Pharmacokinetic Parameters ◽  
Tumor Accumulation ◽  
Plasma Pharmacokinetic

scholarly journals Plasma Pharmacokinetic Parameters of Dexamethasone Following Administration of a Dexamethasone Intracanalicular Insert in Healthy Adults

2021 ◽  
Vol Volume 15 ◽  
pp. 2055-2061
Author(s):  
Charles Blizzard ◽  
Eugene B McLaurin ◽  
Arthur Driscoll ◽  
Fabiana Q Silva ◽  
Srilatha Vantipalli ◽  
...  
Keyword(s):  
Healthy Adults ◽  
Pharmacokinetic Parameters ◽  
Plasma Pharmacokinetic

scholarly journals Pharmacokinetic Parameters and Tissue Withdrawal Intervals for Sheep Administered Multiple Oral Doses of Meloxicam

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2797
Author(s):  
Sarah Depenbrock ◽  
Tara Urbano ◽  
Jessie Ziegler ◽  
Scott Wetzlich ◽  
Maaike O. Clapham ◽  
...  
Keyword(s):  
Regulatory Agency ◽  
Multiple Dose ◽  
Pharmacokinetic Parameters ◽  
Pharmacokinetic Studies ◽  
Plasma Samples ◽  
Follow Up Study ◽  
Sample Data ◽  
Oral Doses ◽  
Plasma Pharmacokinetic

Meloxicam is an anti-inflammatory drug used to treat pain and inflammation in ruminants including sheep, and pharmacokinetic studies are needed to protect the food supply from drug residues after use in food-producing animals. This study estimated plasma pharmacokinetic parameters and meat withdrawal intervals (WDI) for market sheep after multiple daily oral doses of meloxicam. Single and multiple dose plasma pharmacokinetic studies, a multi-dose tissue depletion study, and a follow-up study to investigate if events prior to slaughter were associated with differences in plasma meloxicam concentrations, all using sample data collected after completion of dosing, were completed. Using regulatory agency methods for calculating withdrawal times, an estimated WDI of at least 10 d following the last dose is recommended for market lambs treated with 10 daily oral 1 mg/kg doses of meloxicam tablets suspended in water. The effect of events surrounding slaughter on plasma meloxicam concentrations in lambs is unknown but should be considered if plasma samples are obtained immediately prior to or during the slaughter process and used for pharmacokinetic investigations.

Some Plasma Pharmacokinetic Parameters of Isoniazid in the Presence of a Fluoroquinolone Antibacterial Agent

2001 ◽  
Vol 8 (4) ◽  
pp. 243-246 ◽  
Author(s):  
Sabinus I. Ofoefule ◽  
Chioma E. Obodo ◽  
Orish E. Orisakwe ◽  
Ndidiamaka A. Ilondu ◽  
Onyenmechi J. Afonne ◽  
...  
Keyword(s):  
Antibacterial Agent ◽  
Pharmacokinetic Parameters ◽  
Plasma Pharmacokinetic

scholarly journals Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4241
Author(s):  
Jesús Alfredo Araujo-León ◽  
Rolffy Ortiz-Andrade ◽  
Rivelino Armando Vera-Sánchez ◽  
Julio Enrique Oney-Montalvo ◽  
Tania Isolina Coral-Martínez ◽  
...  
Keyword(s):  
Multiple Reaction Monitoring ◽  
Detection Limits ◽  
High Sensitivity ◽  
Rat Plasma ◽  
Pharmacokinetic Parameters ◽  
Intragastric Administration ◽  
Validation Parameters ◽  
Plasma Pharmacokinetic ◽  
Pharmacokinetic Approach

The purpose of this study was to develop, optimize, and fully validate a high-sensitivity methodology using UHPLC-MS/MS to simultaneously quantify hesperidin and naringenin in microsamples (100 µL) of murine plasma after intragastric administration of single pure flavonoids and a mixture. The optimization process allowed for high sensitivity with detection limits of approximately picogram order using an electrospray ionization (ESI) source in negative mode and an experiment based on multiple reaction monitoring (MRM). The validation parameters showed excellent linearity and detection limits, with a precision of less than 8% and a recovery of over 90%. This methodology was applied to compare the pharmacokinetic parameters for the administration of hesperidin and naringenin in individual form or in the form of a mixture. The results showed an absence of significant effects (p > 0.05) for Tmax and Cmax; however, the AUC presented significant differences (p < 0.05) for both flavonoids when administered as a mixture, showing an improved absorption ratio for both flavonoids.

Sensitive Inexpensive HPLC Determination of Novel Anticancer Combination in Nanoparticles and Rat Plasma: Pharmacokinetic Application

2020 ◽  
Vol 58 (4) ◽  
pp. 334-345
Author(s):  
Nayra M Kamel ◽  
Magda W Samaha ◽  
Ahmed O Elzoghby ◽  
Eman I El-Kimary
Keyword(s):  
Combination Therapy ◽  
High Performance ◽  
Internal Standard ◽  
Gradient Elution ◽  
Rat Plasma ◽  
Detection Methods ◽  
Pharmacokinetic Parameters ◽  
Bioanalytical Method Validation ◽  
Plasma Pharmacokinetic

Abstract Two high-performance liquid chromatography-diode array detection methods have been developed and validated for the simultaneous quantification of genistein (GNS) and all trans retinoic acid (ATRA) as a novel anticancer combination therapy in their co-formulated nanoparticles and in rat plasma. Separation was performed on C18 column (250 × 4.6 mm, 5 μm) using celecoxib as internal standard. A mobile phase containing acetonitrile and water adjusted to pH 3 using 1% trifluoroacetic acid was delivered in gradient elution modes with time programmed UV detection. For extraction of the drugs and the internal standard from rat plasma, liquid- liquid extraction was applied. The proposed methods were validated as per International Conference on Harmonisation (ICH) guidelines (in the range 0.1–10 μg/mL for analysis of GNS and ATRA in nanoparticles) or according to Food and Drug Administration (FDA) guidance on bioanalytical method validation (in the range 0.025–20 μg/mL for analysis of GNS and ATRA in rat plasma). Pharmacokinetic study in six rats was performed following intravenous (IV) administration of a single dose of 0.5 mg/Kg of GNS and ATRA. The drugs’ concentrations were measured up to 24 hours, and different pharmacokinetic parameters were calculated. The obtained parameters were comparable with the reported values for IV administration of each drug alone in rats. This confirms the applicability of the proposed method in monitoring the levels of the two drugs in vivo following their coadministration and indicating that the two drugs could be coadministered as a promising novel combination therapy for the treatment of lung cancer without great alteration in their pharmacokinetic parameters compared with their individual IV administration.

Sign in / Sign up

Export Citation Format

Share Document