Tumor scintigraphy by the method for subtracting the initial image with technetium-99m labeled antibody

1999 ◽  
Vol 13 (6) ◽  
pp. 407-413
Author(s):  
Yoshiharu Karube ◽  
Kentaro Katsuno ◽  
Sanae Ito ◽  
Kazuhisa Matsunaga ◽  
Jiro Takata ◽  
...  
Keyword(s):  
Initial Image ◽  
Technetium 99M ◽  
Tumor Scintigraphy

Low-light-level three-dimensional video microscope with long working distance objective lenses

1994 ◽  
Vol 52 ◽  
pp. 226-227
Author(s):  
W. Lin ◽  
J. Gregorio ◽  
T.J. Holmes ◽  
D. H. Szarowski ◽  
J.N. Turner
Keyword(s):  
Three Dimensional ◽  
Light Level ◽  
Stereo Pair ◽  
Light Illumination ◽  
Initial Image ◽  
Low Light ◽  
Image Recording ◽  
Depth Discrimination ◽  
Video Microscope ◽  
Working Distance

A low-light level video microscope with long working distance objective lenses has been built as part of our integrated three-dimensional (3-D) light microscopy workstation (Fig. 1). It allows the observation of living specimens under sufficiently low light illumination that no significant photobleaching or alternation of specimen physiology is produced. The improved image quality, depth discrimination and 3-D reconstruction provides a versatile intermediate resolution system that replaces the commonly used dissection microscope for initial image recording and positioning of microelectrodes for neurobiology. A 3-D image is displayed on-line to guide the execution of complex experiments. An image composed of 40 optical sections requires 7 minutes to process and display a stereo pair.The low-light level video microscope utilizes long working distance objective lenses from Mitutoyo (10X, 0.28NA, 37 mm working distance; 20X, 0.42NA, 20 mm working distance; 50X, 0.42NA, 20 mm working distance). They provide enough working distance to allow the placement of microelectrodes in the specimen.

Technetium 99m compounds for visualization of body organs

JAMA ◽  
1965 ◽  
Vol 194 (2) ◽  
pp. 152-156 ◽  
Author(s):  
M. K. Loken
Keyword(s):  
Technetium 99M

Nuklearmedizin

2009 ◽  
Vol 29 (03) ◽  
pp. 168-178
Author(s):  
M. Backhaus ◽  
D. Sandrock
Keyword(s):  
Fdg Pet ◽  
Wird Eine ◽  
Technetium 99M

ZusammenfassungDie beiden wichtigsten nuklearmedizinischen Verfahren in der Rheumatologie sind die Skelettszintgrafie und die F-18-Fluor-Desoxyglucose-Positronenemissionstomografie (F-18-FDG-PET). Bei der Skelettszintigrafie wird die Anreicherung von i. v.-applizierten Technetium-99m-markierten Phosphonaten mittels einer Gamma-Kamera untersucht. Man unterscheidet Perfusionsphase (0–60 sec p. i.), Blutpoolphase (2–5 min p. i.) und Knochenstoffwechselphase (2–5 h p. i.). Die Blutpoolphase erlaubt Aussagen über die entzündliche (Weichteil-)Komponente („Arthritis“), die Knochenstoffwechselphase über länger dauernde knöcherne Prozesse („Arthrose“). Die Positronenemissionstomografie (PET) mit F-18-Fluor-Desoxyglucose (FDG) eignet sich bei einer Vielzahl von Indikationen in der Onkologie. Bei rheumatologischen Fragestellungen wird nach benignen Prozessen mit gesteigertem Glukosestoffwechsel gesucht. Dabei handelt es sich um Entzündungen in Weichteilgeweben und Gelenken (z. B. Ar-thritiden, Vaskulitiden) und insbesondere zur Diagnostik unklaren Fiebers. Im Regelfall wird eine Ganzkörpertomografie als Aufnahmeverfahren für die Fokussuche unbekannter Lokalisation oder zur Darstellung der Höhe des Glukosestoffwechsels eines oder mehrerer bekannter Herde genutzt. Verlaufsuntersuchungen unter Therapie können durchgeführt werden. Bei der Untersuchung soll der Patient nüchtern sein. Die Aufnahme erfolgt eine Stunde nach FDG-Injektion für eine Dauer von 30–60 min. Die Methode ist sensitiv und kann den Stoffwechsel von Läsionen objektivieren, ist aber nicht spezifisch (FDG reichert sich auch in malignen Veränderungen an). Die technischen Einzelheiten einschließlich Befunddokumentation beider Verfahren sind entsprechend den Leitlinien der Deutschen Gesellschaft für Nuklearmedizin dargestellt (www.nuklearmedizin.de).

99mTc Technetium Sulfide and the Scintillation Camera in the Rapid Diagnosis of Pericardial Effusion

1971 ◽  
Vol 10 (02) ◽  
pp. 122-128
Author(s):  
W. H. Blahd ◽  
M. A. Winston ◽  
G. T. Krishnamurthy ◽  
P. B. Thomas ◽  
E. Weiss
Keyword(s):  
Pericardial Effusion ◽  
Patient Positioning ◽  
Rapid Diagnosis ◽  
Scintillation Camera ◽  
Technical Error ◽  
Technetium 99M ◽  
Sodium Pertechnetate ◽  
Specific Uptake ◽  
Speed Accuracy

SummaryBecause of its speed, accuracy, and reproducibility, radioisotopic angiocardiography appears to be the method of choice for the diagnosis of pericardial effusion. Technetium-99m sulfide is preferable to 99mTc sodium pertechnetate in these studies for the following reasons: (1) its specific uptake by the liver aids both in patient positioning and in the accuracy of diagnosis; and (2), studies can be repeated within 15—20 minutes should there be equiment or technical error.

First experiences with a new radiopharmaceutical for sentinel lymph node detection in malignant melanoma

2004 ◽  
Vol 43 (01) ◽  
pp. 10-15 ◽  
Author(s):  
R. A. Schmid ◽  
C. Kunte ◽  
B. Konz ◽  
K. Hahn ◽  
M. Weiss
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Malignant Melanoma ◽  
Sentinel Node ◽  
Gamma Probe ◽  
Blue Dye ◽  
Sentinel Nodes ◽  
Technetium 99M ◽  
Positive Rate ◽  
Metastatic Involvement

Summary Aim of this study was to localize the sentinel lymph node by lymphoscintigraphy using technetium-99m colloidal rhenium sulphide (Nanocis®), a new commercially available radiopharmaceutical. Due to the manufacturers’ instructions it is licensed for lymphoscintigraphy. Patients, methods: 35 consecutive patients with histologically proved malignant melanoma, but without clinical evidence of metastases, were preoperatively examined by injecting 20-40 MBq Nanocis® with (mean particle size: 100 nm; range: 50-200 nm) intradermally around the lesion. Additionally blue dye was injected intaoperatively. A hand-held gamma probe guided sentinel node biopsy. Results: During surgery, the preoperatively scintigraphically detected sentinel lymph nodes were identified in 34/35 (97%) patients. The number of sentinel nodes per patient ranged from one to four (mean: n = 1.8). Histologically, metastatic involvement of the sentinel lymph node was found in 12/35 (34%) patients; the sentinel lymph node positive-rate (14/63 SLN) was 22%. Thus, it is comparable to the findings of SLN-mapping using other technetium-99m-labeled nanocolloides. Conclusion: 99mTc-bound colloidal rhenium sulphide is also suitable for sentinel node mapping.

Relationship between Thyroglobulin and Tumor Detectabilily with Thallium-201 in Differentiated Thyroid Cancer

2000 ◽  
Vol 39 (01) ◽  
pp. 10-15 ◽  
Author(s):  
S. P. Müller ◽  
Ch. Reiners ◽  
A. Bockisch ◽  
Katja Brandt-Mainz
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Roc Analysis ◽  
Tsh Suppression ◽  
Significant Difference ◽  
Test Specificity ◽  
The Relationship ◽  
Tumor Scintigraphy ◽  
Tsh Stimulation

Summary Aim: Tumor scintigraphy with 201-TICI is an established diagnostic method in the follow-up of differentiated thyroid cancer. We investigated the relationship between thyroglobulin (Tg) level and tumor detectability. Subject and methods: We analyzed the scans of 122 patients (66 patients with proven tumor). The patient population was divided into groups with Tg above (N = 33) and below (N = 33) 5 ng/ml under TSH suppression or above (N = 33) and below (N = 33) 50 ng/ml under TSH stimulation. Tumor detectability was compared by ROC-analysis (True-Positive-Fraction test, specificity 90%). Results: There was no significant difference (sensitivity 75% versus 64%; p = 0.55) for patients above and below 5 ng/ml under TSH suppression and a just significant difference (sensitivity 80% versus 58%; p = 0.04) for patients above and below 50 ng/ml under TSH stimulation. In 18 patients from our sample with tumor, Tg under TSH suppression was negative, but 201-TICI-scan was able to detect tumor in 12 patients. Conclusion: Our results demonstrate only a moderate dependence of tumor detectability on Tg level, probably without significant clinical relevance. Even in patients with slight Tg elevation 201-TICI scintigraphy is justified.

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