Preparation and biodistribution in mice of [11C]carfentanil: A radiopharmaceutical for studying brain μ-opioid receptors by positron emission tomography

1992 ◽  
Vol 6 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Hideo Saji ◽  
Daisuke Tsutsumi ◽  
Yasuhiro Magata ◽  
Yasuhiko Iida ◽  
Junji Konishi ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Opioid Receptors ◽  
Emission Tomography ◽  
Positron Emission ◽  
Μ Opioid Receptors

Imaging of ?- and ?-opioid receptors in temporal lobe epilepsy by positron emission tomography

1997 ◽  
Vol 41 (3) ◽  
pp. 358-367 ◽  
Author(s):  
Igal Madar ◽  
Ronald P. Lesser ◽  
Gregory Krauss ◽  
Jon Kar Zubieta ◽  
John R. Lever ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Opioid Receptors ◽  
Emission Tomography ◽  
Positron Emission

[3H]cyclofoxy, a ligand suitable for positron emission tomography, labels mu and kappa opioid receptors

Neuropeptides ◽  
1987 ◽  
Vol 10 (3) ◽  
pp. 235-239 ◽  
Author(s):  
Stafford McLean ◽  
Kennner C. Rice ◽  
Ralph Lessor ◽  
Richard B. Rothman
Keyword(s):  
Positron Emission Tomography ◽  
Opioid Receptors ◽  
Emission Tomography ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid ◽  
Positron Emission

scholarly journals Quantification of δ-Opioid Receptors in Human Brain with N1′ -([11C]Methyl) Naltrindole and Positron Emission Tomography

1999 ◽  
Vol 19 (9) ◽  
pp. 956-966 ◽  
Author(s):  
Justin S. Smith ◽  
Jon-Kar Zubieta ◽  
Julie C. Price ◽  
John E. Flesher ◽  
Igal Madar ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Human Brain ◽  
Opioid Receptors ◽  
Receptor Binding ◽  
Specific Activity ◽  
High Specific Activity ◽  
Emission Tomography ◽  
Opioid Antagonist ◽  
Tracer Transport ◽  
Positron Emission

The regional binding of N1′ -([11C]methyl)naltrindole (MeNTI), a selective δ-opioid antagonist, was studied in healthy human subjects with positron emission tomography (PET). After the bolus intravenous administration of high specific activity [11C]MeNTI, PET was performed over 90 minutes. Arterial plasma samples were obtained during the scanning period and assayed for the presence of radiolabeled metabolites. The data were analyzed with various kinetic (two-and three-compartment models, Patlak graphical analysis) and nonkinetic (apparent volume of distribution and activity at a late scanning time) approaches. This tracer showed irreversible binding characteristics during the scanning period used. The results of the analyses also were compared with the density and distribution of δ-opioid receptors in the human brain in vitro. Additionally, computer simulations were performed to assess the effects of changes in receptor binding and tracer transport changes on the perceived binding parameters obtained with the models. A constrained three-compartment kinetic model was demonstrated to be superior to other quantification models for the description of MeNTI kinetics and quantification of δ receptor binding in the human brain with 11C-labeled MeNTI.

scholarly journals Kappa-opioid receptors, dynorphin, and cocaine addiction: a positron emission tomography study

2019 ◽  
Vol 44 (10) ◽  
pp. 1720-1727 ◽  
Author(s):  
Diana Martinez ◽  
Mark Slifstein ◽  
David Matuskey ◽  
Nabeel Nabulsi ◽  
Ming-Qiang Zheng ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Opioid Receptors ◽  
Cocaine Addiction ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Kappa Opioid Receptors ◽  
Kappa Opioid ◽  
Positron Emission

Positron Emission Tomography (PET) Imaging of Opioid Receptors

2014 ◽  
pp. 585-623 ◽  
Author(s):  
Aren van Waarde ◽  
Anthony R. Absalom ◽  
Anniek K. D. Visser ◽  
Rudi A. J. O. Dierckx
Keyword(s):  
Positron Emission Tomography ◽  
Opioid Receptors ◽  
Pet Imaging ◽  
Emission Tomography ◽  
Positron Emission

Positron Emission Tomography (PET) Imaging of Opioid Receptors

2020 ◽  
pp. 749-807
Author(s):  
Aren van Waarde ◽  
Anthony R. Absalom ◽  
Anniek K. D. Visser ◽  
Rudi A. J. O. Dierckx
Keyword(s):  
Positron Emission Tomography ◽  
Opioid Receptors ◽  
Pet Imaging ◽  
Emission Tomography ◽  
Positron Emission
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