Low doses of domoic acid during postnatal development produce permanent changes in rat behaviour and hippocampal morphology

2004 ◽  
Vol 6 (7-8) ◽  
pp. 555-563 ◽  
Author(s):  
T. A. Doucette ◽  
P. B. Bernard ◽  
H. Husum ◽  
M. A. Perry ◽  
C. L. Ryan ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Domoic Acid ◽  
Low Doses ◽  
Hippocampal Morphology

scholarly journals Secretion of adrenal zona glomerulosa cells in rats exposed to low doses of dichlorodiphenyltrichloroethane during prenatal and postnatal development

2018 ◽  
Vol 7 (3) ◽  
pp. e0302
Author(s):  
Dibakhan A. Tsomartova ◽  
Natalia V. Yaglova ◽  
Sergey S. Obernikhin ◽  
Svetlana V. Nazimova ◽  
Valentin V. Yaglov
Keyword(s):  
Postnatal Development ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Glomerulosa Cells ◽  
Prenatal And Postnatal Development ◽  
Zona Glomerulosa Cells

CHANGES IN ADRENAL ZONA GLOMERULOSA CELLS OF RATS EXPOSED TO LOW DOSES OF DDT DURING POSTNATAL DEVELOPMENT

2018 ◽  
Vol 26 (2) ◽  
pp. 25-30
Author(s):  
D.A. Tsomartova ◽  
◽  
N.V. Yaglova ◽  
S.S. Obernikhin ◽  
S.V. Nazimova ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Glomerulosa Cells ◽  
Zona Glomerulosa Cells

Effects of perinatal exposure to low doses of tributyltin chloride on pregnancy outcome and postnatal development in mouse offspring

2011 ◽  
Vol 27 (10) ◽  
pp. 605-612 ◽  
Author(s):  
Jiliang Si ◽  
Jie Li ◽  
Fengmei Zhang ◽  
Guozhen Li ◽  
Quanbin Xin ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Pregnancy Outcome ◽  
Perinatal Exposure ◽  
Low Doses ◽  
Tributyltin Chloride

scholarly journals Differences in adrenal steroid hormones production in pubertal rats exposed to low doses of endocrine disruptor DDT during prenatal and postnatal development

2017 ◽  
Vol 63 (4) ◽  
pp. 306-311 ◽  
Author(s):  
N.V. Yaglova ◽  
D.A. Tsomartova ◽  
V.V. Yaglov
Keyword(s):  
Postnatal Development ◽  
Steroid Hormones ◽  
Endocrine Disruptor ◽  
Wistar Rats ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Adrenal Steroid ◽  
Steroid Profile ◽  
Male Wistar Rats ◽  
Circulatory Disorders

Production of adrenal steroid hormones in pubertal male Wistar rats exposed to low doses of DDT during both prenatal and postnatal and only postnatal development was evaluated. Altered production of all types of steroid hormones and serum steroid profile with opposite changes in rats exposed prenatally and postnatally, and only postnatally was found. The study showed that daily exposure to low doses of DDT enhanced conversion of progesterone to 17OH-progesterone and did not exert selective antiandrogenic or proestrogenic action unlike effect of toxic and subtoxic doses. Impaired morphogenesis of the adrenal cortex and circulatory disorders in zona glomerulosa contributed to reduced aldosterone and sex steroid hormones production.

scholarly journals Impaired Morphogenesis and Function of Rat Adrenal Zona Glomerulosa by Developmental Low-Dose Exposure to DDT Is Associated with Altered Oct4 Expression

2021 ◽  
Vol 22 (12) ◽  
pp. 6324
Author(s):  
Nataliya V. Yaglova ◽  
Sergey S. Obernikhin ◽  
Dibakhan A. Tsomartova ◽  
Svetlana V. Nazimova ◽  
Valentin V. Yaglov ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Low Dose ◽  
Organic Pollutant ◽  
Endocrine Disrupting Chemicals ◽  
Zona Glomerulosa ◽  
Low Doses ◽  
Hormone Production ◽  
Functional Changes ◽  
And Function ◽  
The Impact

Dichlorodiphenyltrichloroethane (DDT) is a persistent organic pollutant and one of the most widespread endocrine disrupting chemicals. The impact of low-dose exposure to DDT on the morphogenesis of the adrenal gland is still poorly understood. The development and function of zona glomerulosa in rats has been found to be associated with changes in the expression of the transcription factor Oct4 (Octamer 4), which is the most important player in cell pluripotency. The aim of the study was to investigate the morphogenesis and function of rat adrenal zona glomerulosa in rats exposed to low doses of DDT during prenatal and postnatal development and to determine the possible role of Oct4 in DDT-mediated structural and functional changes. The DDT-exposed rats demonstrated slower development and lower functional activity of the zona glomerulosa during the pubertal period associated with higher expression of Oct4. Further, accelerated growth and restoration of hormone production was associated with, firstly, a decrease in Oct4 expressing cells and secondly, the loss of the inverse relationship between basal aldosterone levels and the number of Oct4 expressing cells. Thus, the transcriptional factor Oct4 exhibited an altered pattern of expression in the DDT-exposed rats during postnatal development. The results of the study uncover a novel putative mechanism by which low doses of DDT disrupt the development of adrenal zona glomerulosa.

REGULATION OF ADRENAL RETICULARIS CELL’S PROLIFERATION IN ORGANISM DEVELOPMENTALLY EXPOSED TO LOW DOSES OF DDT

2020 ◽  
Author(s):  
Svetlana Vladimirovna Nazimova ◽  
Nataliya Valentinovna Yaglova ◽  
Dibakhan Aslanbekovna Tsomartova ◽  
Sergey Stanislavovich Obernikhin ◽  
Valentin Vasilyevich Yaglov
Keyword(s):  
Cell Proliferation ◽  
Postnatal Development ◽  
Proliferative Activity ◽  
Transcriptional Factor ◽  
Low Doses ◽  
Endocrine Disrupter ◽  
Zona Reticularis

Altered patterns of cell proliferation in adrenal zona reticularis during postnatal development and regulation of proliferative activity by transcriptional factor PRH were revealed in rats exposed to endocrine disrupter DDT.

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