MPP+-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity

2003 ◽  
Vol 5 (6) ◽  
pp. 407-410 ◽  
Author(s):  
R. Aguilar Hernández ◽  
M. J. Sánchez De Las Matas ◽  
C. Arriagada ◽  
C. Barcia ◽  
P. Caviedes ◽  
...  
Keyword(s):  
Cell Line ◽  
Oxidative Metabolism ◽  
Dopaminergic Cell ◽  
Dopamine Neurotoxicity

Identification of hypoxia-responsive genes in a dopaminergic cell line by subtractive cDNA libraries and microarray analysis

2001 ◽  
Vol 7 (3) ◽  
pp. 273-281 ◽  
Author(s):  
D Beitner-Johnson ◽  
K Seta ◽  
Y Yuan ◽  
H.-W Kim ◽  
R.T Rust ◽  
...  
Keyword(s):  
Cell Line ◽  
Microarray Analysis ◽  
Cdna Libraries ◽  
Dopaminergic Cell

25 Mechanism of cell death caused by complex 1 defects in a rat dopaminergic cell line

Mitochondrion ◽  
2007 ◽  
Vol 7 (6) ◽  
pp. 411
Author(s):  
M. Marella ◽  
B.B. Seo ◽  
A. Matsuno-Yagi ◽  
T. Yagi
Keyword(s):  
Cell Death ◽  
Cell Line ◽  
Dopaminergic Cell

Neuroprotective role of ERK1/2 and ERK5 in a dopaminergic cell line under basal conditions and in response to oxidative stress

2006 ◽  
Vol 84 (6) ◽  
pp. 1367-1375 ◽  
Author(s):  
Jane E. Cavanaugh ◽  
Juliann D. Jaumotte ◽  
Joan M. Lakoski ◽  
Michael J. Zigmond
Keyword(s):  
Oxidative Stress ◽  
Cell Line ◽  
Dopaminergic Cell

Gallic Acid Protects 6-OHDA Induced Neurotoxicity by Attenuating Oxidative Stress in Human Dopaminergic Cell Line

2018 ◽  
Vol 43 (6) ◽  
pp. 1150-1160 ◽  
Author(s):  
Y. Chandrasekhar ◽  
G. Phani Kumar ◽  
E. M. Ramya ◽  
K. R. Anilakumar
Keyword(s):  
Oxidative Stress ◽  
Gallic Acid ◽  
Cell Line ◽  
Dopaminergic Cell

Superoxide-hydrogen peroxide imbalance differentially modulates the keratinocytes cell line (HaCaT) oxidative metabolism via Keap1-Nrf2 redox signaling pathway

2019 ◽  
Vol 46 (6) ◽  
pp. 5785-5793 ◽  
Author(s):  
Micheli Lamberti Jobim ◽  
Verônica Farina Azzolin ◽  
Charles Elias Assmann ◽  
Vera Maria Melchiors Morsch ◽  
Ivana Beatrice Mânica da Cruz ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Line ◽  
Signaling Pathway ◽  
Oxidative Metabolism ◽  
Redox Signaling

scholarly journals Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCδ phosphorylation

2009 ◽  
Vol 25 (4) ◽  
pp. 187-195 ◽  
Author(s):  
Ying Fan ◽  
Yan-Qiao Zhang ◽  
Dian-Jun Sun ◽  
Yi-Na Zhang ◽  
Xiao-Wei Wu ◽  
...  
Keyword(s):  
Cell Line ◽  
Dopaminergic Cell ◽  
6 Hydroxydopamine

Imatinib Mesylate Induced Reversal of Leukemic Gene Phenotype in HL60 Cells Coincides with Stimulation of Oxidative Metabolism.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4190-4190
Author(s):  
Michael Pfeilstocker ◽  
Peter Wihlidal ◽  
Franz Varga ◽  
Elisabeth Pittermann ◽  
Heidrun Karlic
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factors ◽  
Cell Line ◽  
Imatinib Mesylate ◽  
Oxidative Metabolism ◽  
Myeloid Leukemia ◽  
Fat Metabolism ◽  
Fold Stimulation ◽  
Stimulation Of

Abstract Besides blockade of tyrosine kinases such as c-kit, Imatinib mesylate (IM) regulates glucose flux through downregulation of GLUT-1 transporters in human leukemia cells. This mechanism has the potential to induce regression of type 2 diabetes and hyperlipidemia as observed in patients with chronic myeloid leukemia or hypereosinophilic syndrome. In addition, there is a stimulatory effect of IM on differentiation of human mesenchymal stem cells. Its synergism with retinoic acid or low dose Ara-C is applied in treatment of acute myeloid leukemia (AML). Thus, the AML-derived c-kit positive cell line HL60 was chosen for studying the effect of IM on expression of genes associated with differentiation and metabolism. We analysed the possible feedback on transcription factors (AML1 and AML3) and consequences regarding differentiation and metabolism - associated genes. Quantitative reverse transcriptase PCR analyses revealed that IM treatment of HL60 cells downregulates mRNA synthesis of AML1 and AML3 by 70% without affecting transcription of the c-abl tyrosine kinase. IM reduces expression of CD34 mRNA from 20% to 6% of the housekeeping gene G6PD. The appearance of differentiated cells was accompanied by a remarkable stimulation of mRNAs from CD11b and CD14 (monocyte markers) reaching 4-fold higher expression levels relative to G6PD. This was associated with an increased proportion of osteocalcin (OCN), which has recently been shown to enhance mitochondrial activity. A 2-fold stimulation of a fat-metabolism associated mitochondrial palmitoyltransferase (CPT1B) and 10-fold stimulation of microsomal carnitine palmitoyltransferase and the carnitine transporter OCTN2 supports previous data indicating an IM-associated stimulation of oxidative metabolism resulting in a regression of type-2 diabetes and hyperlipidemia. Our current investigations show that IM-associated attenuation of cell proliferation inhibited transcription factors AML1 and AML3 and triggered differentiation in the leukemic cell line HL60, as reflected by altered mRNA expression of surface marker genes. The IM - induced stimulation of lipid metabolism in HL60 confirms previous data indicating a reversal of the Warburg effect in K562 cells without cytocidal activity. This indicates a similar mechanism as known for other drugs and strategies targeting glucose or fat metabolism, which are discussed in the context of cancer prevention and treatment.

Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis

2011 ◽  
Vol 489 (3) ◽  
pp. 192-196 ◽  
Author(s):  
Yamaratee Jaisin ◽  
Anusorn Thampithak ◽  
Benjawan Meesarapee ◽  
Piyanee Ratanachamnong ◽  
Apichart Suksamrarn ◽  
...  
Keyword(s):  
Cell Line ◽  
Dopaminergic Cell ◽  
6 Hydroxydopamine ◽  
Curcumin I
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