Inappropriate thyroid-stimulating hormone release in the elderly?

1985 ◽  
Vol 15 (2) ◽  
Author(s):  
Antonio E. Pontiroli ◽  
Miriam Alberetto ◽  
Guido Pozza
Keyword(s):  
The Elderly ◽  
Thyroid Stimulating Hormone ◽  
Hormone Release ◽  
Stimulating Hormone

scholarly journals Hipotiroidismo Subclínico no Idoso

2018 ◽  
Vol 31 (12) ◽  
pp. 766
Author(s):  
Sofia Macedo Silva ◽  
Alexandra Carvalho ◽  
Maria Lopes- Pereira ◽  
Vera Fernandes
Keyword(s):  
Subclinical Hypothyroidism ◽  
The Elderly ◽  
Thyroid Stimulating Hormone ◽  
Reference Level ◽  
Thyroid Antibodies ◽  
Electronic Database Search ◽  
Definition Of ◽  
A Minor ◽  
In The Beginning ◽  
Stimulating Hormone

Introduction: Subclinical hypothyroidism, defined as an increase of thyroid stimulating hormone levels with normal levels of thyroid hormones, could have a multiorgan impact. There seem to be differences in the elderly (over 65 years of age) which indicate that there should be a different approach in terms of diagnosis and the treatment.Material and Methods: Electronic database search and narrative bibliographical review.Results: Different case studies showing the multiorgan consequences of subclinical hypothyroidism suggest that, in the elderly, there is a minor impact or even a lack of repercussion, especially in those over 80 - 85 years old. Additionally, there is evidence indicating that the levels of thyroid stimulating hormone rise with the age of the patient. The standard treatment, in the beginning, is a low dose of levothyroxine when the levels of thyroid stimulating hormone are over 10.0 mIU/L, when there are noticeable symptoms or positive anti-thyroid antibodies. However, the treatment is not consensual when the levels of thyroid stimulating hormone are between 4.5 and 10.0 mIU/L, in such a way that the TRUST study concluded that no benefits have outcome from treating these patients. Discussion: The non-definition of the reference range and the age gap are the key factors that contribute the most to biased results. However, there is consensus regarding non-treatment of mild thyroid dysfunctions (4.5 - 7.0 mIU/L) in the elderly, particularly above 80 years of age. Nevertheless, for positive anti-thyroid antibodies, suggestive ultrasound changes or iatrogenic side effects, the reference level should be 4.5 mIU/L. Conclusion: The general impact of subclinical hypothyroidism is different in elderly people, meaning that an individualized therapeutic approach and long-term monitoring is the appropriate strategy.

scholarly journals Hypopituitarism in the elderly in the presence of elevated thyroid stimulating hormone levels.

1988 ◽  
Vol 64 (758) ◽  
pp. 943-944
Author(s):  
T. Beringer ◽  
B. McClements ◽  
I. Weir ◽  
D. Gilmore ◽  
L. Kennedy
Keyword(s):  
The Elderly ◽  
Thyroid Stimulating Hormone ◽  
Hormone Levels ◽  
Stimulating Hormone

scholarly journals Serum Thyroid-Stimulating Hormone Levels and Frailty in the Elderly: The Progetto Veneto Anziani Study

2017 ◽  
Vol 20 (3) ◽  
pp. 165-172 ◽  
Author(s):  
Nicola Veronese ◽  
Sara Fernando-Watutantrige ◽  
Stefania Maggi ◽  
Marianna Noale ◽  
Brendon Stubbs ◽  
...  
Keyword(s):  
The Elderly ◽  
Thyroid Stimulating Hormone ◽  
Hormone Levels ◽  
Stimulating Hormone

scholarly journals SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals

PLoS ONE ◽  
2010 ◽  
Vol 5 (7) ◽  
pp. e11755 ◽  
Author(s):  
Sayaka Akieda-Asai ◽  
Nobuhiro Zaima ◽  
Koji Ikegami ◽  
Tomoaki Kahyo ◽  
Ikuko Yao ◽  
...  
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Hormone Release ◽  
Lysine Residues ◽  
Stimulating Hormone

Thyroid Stimulating Hormone and Growth Hormone Responses to Thyrotropin Releasing Hormone in Anorexia Nervosa

1981 ◽  
Vol 10 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Mark S. Gold ◽  
A. L. C. Pottash ◽  
David M. Martin ◽  
Lawrence B. Finn ◽  
Robert K. Davies
Keyword(s):  
Growth Hormone ◽  
Anorexia Nervosa ◽  
Thyroid Stimulating Hormone ◽  
Thyrotropin Releasing Hormone ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Hormone Response ◽  
Releasing Hormone ◽  
Hormone Responses ◽  
Stimulating Hormone

Ten female patients who satisfied objective criteria for the diagnosis of anorexia nervosa were given 500 ug of thyrotropin releasing hormone. Thyroid stimulating hormone and growth hormone responses were measured in duplicate by radioimmunoassay. These patients had a low normal Δ thyroid stimulating hormone but a delayed peak response. In addition, these patients had pathological growth hormone release in response to thyrotropin releasing hormone infusion. Both delayed peak thyroid stimulating hormone and growth hormone response to thyrotropin releasing hormone have been reported for patients with hypothalamic disorders.

scholarly journals Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (Tursiops truncatus)

2021 ◽  
Vol 2 (2) ◽  
pp. 265-272
Author(s):  
Dorian S. Houser ◽  
Cory Champagne ◽  
Daniel E. Crocker
Keyword(s):  
Tursiops Truncatus ◽  
Bottlenose Dolphins ◽  
Thyroid Stimulating Hormone ◽  
Hormone Release ◽  
Total Triiodothyronine ◽  
Stimulation Tests ◽  
Total Thyroxine ◽  
Recombinant Tsh ◽  
Tsh Stimulation ◽  
Stimulating Hormone

Stimulation of the thyroid with thyroid-stimulating hormone (TSH) is a potentially useful diagnostic of thyroid dysfunction, but little is known about the response of the thyroid to TSH stimulation in bottlenose dolphins (Tursiops truncatus). To better characterize the response of the dolphin thyroid to TSH stimulation, five adult dolphins participated in a TSH stimulation study. Dolphins voluntarily beached onto a padded mat and were given a 1.5 mg intramuscular injection of human recombinant TSH. Blood samples collected the day prior, at multiple intervals the day of, and daily for three days after the injection were analyzed via radioimmunoassay for free and total triiodothyronine (fT3 and tT3), and free and total thyroxine (fT4 and tT4). Significant increases in circulating fT3, fT4, and tT4 were observed with peaks occurring for all hormones the day after the TSH injection; maximal increases were 44%, 47%, and 23% for each hormone, respectively. Temporal patterns in the hormones potentially reflected feedback mechanisms countering the surge in fT3 following stimulation. Though recombinant human TSH was effective at stimulating hormone release, it is likely that use of dolphin or dolphin-derived TSH would enhance the clinical utility of the stimulation test, as would the development of antibodies specific to dolphin TSH.

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