Modulation of dorsal horn neuronal activity by spinal cord stimulation in a rat model of neuropathy: The role of the dorsal funicles

1998 ◽  
Vol 30 (6) ◽  
pp. 424-427 ◽  
Author(s):  
V. A. Yakhnista ◽  
B. Linderoth ◽  
B. A. Meyerson
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Neuronal Activity ◽  
Rat Model ◽  
Spinal Cord Stimulation

The role of the dorsolateral funiculi in the pain relieving effect of spinal cord stimulation: a study in a rat model of neuropathic pain

2014 ◽  
Vol 233 (4) ◽  
pp. 1041-1052 ◽  
Author(s):  
N. E. Saadé ◽  
J. Barchini ◽  
S. Tchachaghian ◽  
F. Chamaa ◽  
S. J. Jabbur ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Rat Model ◽  
Spinal Cord Stimulation

Spinal cord stimulation attenuates dorsal horn neuronal hyperexcitability in a rat model of mononeuropathy

Pain ◽  
1999 ◽  
Vol 79 (2) ◽  
pp. 223-233 ◽  
Author(s):  
Vadym Yakhnitsa ◽  
Bengt Linderoth ◽  
Björn A Meyerson
Keyword(s):  
Spinal Cord ◽  
Dorsal Horn ◽  
Rat Model ◽  
Spinal Cord Stimulation ◽  
Neuronal Hyperexcitability

Acetaminophen Inhibits Spinal Prostaglandin E2Release after Peripheral Noxious Stimulation 

1999 ◽  
Vol 91 (1) ◽  
pp. 231-239 ◽  
Author(s):  
Uta S. Muth-Selbach ◽  
Irmgard Tegeder ◽  
Kay Brune ◽  
Gerd Geisslinger
Keyword(s):  
Spinal Cord ◽  
Urinary Excretion ◽  
Dorsal Horn ◽  
Formalin Test ◽  
Intraperitoneal Administration ◽  
Noxious Stimulation ◽  
Cyclooxygenase Inhibitor ◽  
Nociceptive Processing ◽  
Pge2 Release

Background Prostaglandin play a pivotal role in spinal nociceptive processing. At therapeutic concentrations, acetaminophen is not a cyclooxygenase inhibitor. inhibitor. Thus, it is antinociceptive without having antiinflammatory or gastrointestinal toxic effects. This study evaluated the role of spinal prostaglandin E2 (PGE2) in antinociception produced by intraperitoneally administered acetaminophen. Methods The PGE2 concentrations in the dorsal horn of the spinal cord were measured after formalin was injected into the hind paw of rats. The effect of antinociceptive doses of acetaminophen (100, 200, and 300 mg/kg given intraperitoneally) on PGE2 levels and flinching behavior was monitored Spinal PGE2 and acetaminophen concentrations were obtained by microdialysis using a probe that was implanted transversely through the dorsal horn of the spinal cord at L4. Furthermore, the effects of acetaminophen on urinary prostaglandin excretion were determined. Results Intraperitoneal administration of acetaminophen resulted in a significant decrease in spinal PGE2 release that was associated with a significant reduction in the flinching behavior in the formalin test Acetaminophen was distributed rapidly into the spinal cord with maximum dialysate concentrations 4560 min after intraperitoneal administration. Urinary excretion of prostanoids (PGE2, PGF2alpha, and 6-keto-PGF1alpha) was not significantly altered after acetaminophen administration. Conclusions The data confirm the importance of PGE2 in spinal nociceptive processing. The results suggest that antinociception after acetaminophen administration is mediated, at least in part, by inhibition of spinal PGE2 release. The mechanism, however, remains unknown. The finding that urinary excretion of prostaglandins was not affected might explain why acetaminophen is antinociceptive but does not compromise renal safety.

Modulation of neuronal activity after spinal cord stimulation for neuropathic pain; H215O PET study

NeuroImage ◽  
2010 ◽  
Vol 49 (3) ◽  
pp. 2564-2569 ◽  
Author(s):  
Haruhiko Kishima ◽  
Youichi Saitoh ◽  
Satoru Oshino ◽  
Koichi Hosomi ◽  
Mohamed Ali ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Neuronal Activity ◽  
Spinal Cord Stimulation ◽  
H215o Pet

Protective role of β-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury

2018 ◽  
Vol 61 ◽  
pp. 92-99 ◽  
Author(s):  
Lihui Zhou ◽  
Lian Ouyang ◽  
Shuangzhi Lin ◽  
Song Chen ◽  
YingJie Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Protective Role ◽  
Cord Injury ◽  
Β Carotene

scholarly journals Role of microglia in the spinal cord in colon‐to‐bladder neural crosstalk in a rat model of colitis

2018 ◽  
Vol 37 (4) ◽  
pp. 1320-1328 ◽  
Author(s):  
Tsuyoshi Majima ◽  
Yasuhito Funahashi ◽  
Naoki Kawamorita ◽  
Shun Takai ◽  
Yoshihisa Matsukawa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Rat Model ◽  
Neural Crosstalk
Sign in / Sign up

Export Citation Format

Share Document