scholarly journals Interaction among NMDA receptor-, NMDA glycine site- and AMPA receptor antagonists in spinally mediated analgesia

2000 ◽  
Vol 47 (7) ◽  
pp. 693-698 ◽  
Author(s):  
Tomoki Nishiyama
Keyword(s):  
Nmda Receptor ◽  
Ampa Receptor ◽  
Glycine Site ◽  
Receptor Antagonists

ChemInform Abstract: A Series of Quinoline-2-carboxylic Acid Derivatives: New Potent Glycine Site NMDA Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 29 (7) ◽  
pp. no-no
Author(s):  
R. H. KIM ◽  
J. I. CHOI ◽  
S. W. CHOI ◽  
K. S. LEE ◽  
Y. S. JUNG ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Carboxylic Acid ◽  
Nmda Receptor Antagonists ◽  
Glycine Site ◽  
Receptor Antagonists

scholarly journals Postischemic Blockade of AMPA but Not NMDA Receptors Mitigates Neuronal Damage in the Rat Brain following Transient Severe Cerebral Ischemia

1992 ◽  
Vol 12 (1) ◽  
pp. 2-11 ◽  
Author(s):  
B. Nellgård ◽  
T. Wieloch
Keyword(s):  
Cerebral Ischemia ◽  
Nmda Receptor ◽  
Ampa Receptor ◽  
Neuronal Damage ◽  
Transient Cerebral Ischemia ◽  
Coupled Processes ◽  
Temporal Part ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Cgp 40116

Glutamatergic transmission is an important factor in the development of neuronal death following transient cerebral ischemia. In this investigation the effects of N-methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists on neuronal damage were studied in rats exposed to 10 min of transient cerebral ischemia induced by bilateral common carotid occlusion combined with hypotension. The animals were treated with a blocker of the ionotropic quisqualate or α-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) receptor, 2.3-dihydroxy-6-nitro-7-sulfamoyl-benzo( F)quinoxaline (NBQX), given postischemia as an intraperitoneal bolus dose of 30 mg kg−1 followed by an intravenous infusion of 75 μg min−1 for 6 h, or with the noncompetitive NMDA receptor blocker dizocilpine(MK-801) given 1 mg kg−1 i.p. at recirculation and 3 h postischemia, or with the competitive NMDA receptor antagonist dl-( E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 40116), 5 mg kg−1, given intraperitoneally at recirculation. Treatment with NBQX provided a significant reduction of neuronal damage in the hippocampal CA1 area by 44–69%, with the largest relative decrease in the temporal part of the hippocampus. In neocortex a significant decrease in the number of necrotic neurons was also noted. No protection could be seen following postischemic treatment with dizocilpine or CGP 40116. Our data demonstrate that AMPA but not NMDA receptor antagonists decrease neuronal damage following transient severe cerebral ischemia in the rat and that the protection by NBQX may be dependent on the severity of the ischemic insult. We propose that the AMPA receptor–mediated neurotoxicity could be due to ischemia-induced changes in the control mechanisms of AMPA receptor–coupled processes or to changes of AMPA receptor characteristics.

ChemInform Abstract: 5-Aminomethylquinoxaline-2,3-diones. Part 3. Arylamide Derivatives as Highly Potent and Selective Glycine-Site NMDA Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 29 (24) ◽  
pp. no-no
Author(s):  
P. ACKLIN ◽  
H. ALLGEIER ◽  
Y. P. AUBERSON ◽  
S. BISCHOFF ◽  
S. OFNER ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Glycine Site ◽  
Receptor Antagonists

ChemInform Abstract: trans-2-Carboxy-4-substituted Tetrahydroquinolines. Potent Glycine- Site NMDA Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 22 (45) ◽  
pp. no-no
Author(s):  
P. D. LEESON ◽  
R. W. CARLING ◽  
J. D. SMITH ◽  
R. BAKER ◽  
A. C. FOSTER ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Nmda Receptor Antagonists ◽  
Glycine Site ◽  
Receptor Antagonists
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