scholarly journals Tranexamic acid reduces blood loss and transfusion in adult patients having spinal fusion surgery

2006 ◽  
Vol 53 (1) ◽  
pp. 26385-26385 ◽  
Author(s):  
Jean Wong ◽  
El-Beheiry Hossam ◽  
Yogendran Suntheralingam ◽  
Raja Rampersaud ◽  
Frances Chung
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Spinal Fusion ◽  
Adult Patients ◽  
Fusion Surgery ◽  
Spinal Fusion Surgery

Tranexamic Acid Reduces Perioperative Blood Loss in Adult Patients Having Spinal Fusion Surgery

2008 ◽  
Vol 107 (5) ◽  
pp. 1479-1486 ◽  
Author(s):  
Jean Wong ◽  
Hossam El Beheiry ◽  
Yoga Raja Rampersaud ◽  
Stephen Lewis ◽  
Henry Ahn ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Spinal Fusion ◽  
Adult Patients ◽  
Fusion Surgery ◽  
Spinal Fusion Surgery ◽  
Perioperative Blood Loss

The Efficiency of Simultaneous Systemic and Topical Use of Tranexamic Acid in Spinal Fusion Surgery

2021 ◽  
Author(s):  
Uzay Erdogan ◽  
Seckin Sari ◽  
Ahmet Akbas
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Spinal Fusion ◽  
Adult Patients ◽  
Conservation Strategy ◽  
Postoperative Blood Loss ◽  
Allogenic Blood Transfusion ◽  
Fusion Surgery ◽  
Drainage Fluid ◽  
Spinal Fusion Surgery

Abstract Background and Aim Multilevel posterior spinal fusion surgery in adults is associated with significant intra- and postoperative blood loss. Tranexamic acid (TXA) is an antifibrinolytic agent for reducing blood loss and allogenic blood transfusion. The purpose of this study was to evaluate the efficiency of TXA in reducing blood loss and improving hematologic parameters in adult patients undergoing posterior thoracic/lumbar instrumented spinal fusion surgery. Patients and Methods This is a retrospective observational study comparing the intra- and postoperative hemodynamic findings of two groups treated with and without TXA. The study included 112 adult patients receiving elective posterior thoracic/lumbar instrumented spinal fusion surgery. The patients were evaluated in terms of age, gender, type of surgery, intraoperative blood loss, pre- and postoperative hemoglobin (Hb) and hematocrit values, postoperative systemic anticoagulant use, intra- and postoperative use of blood products, and the volume of the drainage fluid as an indicator of postoperative blood loss. The TXA group received preoperative 10 mg/kg intravenous TXA, another dose of 10 mg/kg/h in isotonic solution during the operation, and local administration of TXA before the closure of the surgical site (1g in patients undergoing surgery in ≤3 segments, and 2g in patients undergoing surgery in ≥4 segment group). Results Intra- and postoperative blood loss and need for transfusion were significantly lower in the TXA group. Fifty-three of 112 patients required intra- and postoperative transfusion, and postoperative anticoagulants were given to 25/112 patients. The postoperative Hb level was lower, and the difference of pre- and postoperative Hb values was higher in the non-TXA group (not significant). Conclusion Simultaneous systemic and topical application of TXA is a safe and efficient blood conservation strategy for adult patients undergoing major multilevel spinal surgery.

scholarly journals Topical use of tranexamic acid can effectively decrease hidden blood loss during posterior lumbar spinal fusion surgery

Medicine ◽  
2017 ◽  
Vol 96 (42) ◽  
pp. e8233 ◽  
Author(s):  
Zhinan Ren ◽  
Shugang Li ◽  
Lin Sheng ◽  
Qianyu Zhuang ◽  
Zheng Li ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Spinal Fusion ◽  
Lumbar Spinal Fusion ◽  
Fusion Surgery ◽  
Spinal Fusion Surgery ◽  
Hidden Blood Loss ◽  
Lumbar Spinal

Effectiveness and Safety of Batroxobin, Tranexamic Acid and a Combination in Reduction of Blood Loss in Lumbar Spinal Fusion Surgery

Spine ◽  
2018 ◽  
Vol 43 (5) ◽  
pp. E267-E273 ◽  
Author(s):  
Roopa M. Nagabhushan ◽  
Ajoy P. Shetty ◽  
Srikanth R. Dumpa ◽  
Balavenkat Subramanian ◽  
Rishi M. Kanna ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Spinal Fusion ◽  
Lumbar Spinal Fusion ◽  
Fusion Surgery ◽  
Spinal Fusion Surgery ◽  
Lumbar Spinal

scholarly journals Combined topical and intravenous administration of tranexamic acid further reduces postoperative blood loss in adolescent idiopathic scoliosis patients undergoing spinal fusion surgery: a randomized controlled trial

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yulei Dong ◽  
Jinqian Liang ◽  
Bingdu Tong ◽  
Jianxiong Shen ◽  
Hong Zhao ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Blood Loss ◽  
Idiopathic Scoliosis ◽  
Tranexamic Acid ◽  
Spinal Fusion ◽  
Postoperative Blood Loss ◽  
Complication Rates ◽  
Fusion Surgery ◽  
Spinal Fusion Surgery ◽  
Link Type

Abstract Background To indicate whether combined topical and intravenous (IV) administration of tranexamic acid (TXA) could further reduce the blood loss after surgery for adolescent idiopathic scoliosis (AIS) compared with IV-TXA alone. Methods Ninety AIS patients who underwent posterior spinal fusion were prospectively randomized to combined group (IV + topical- TXA group) and IV-TXA alone group. TXA was infused at a loading dose of 1 g from the beginning of the surgery with a maintenance dose of 10 mg/kg/h until the wound was closed. In the combined group, 2 g TXA was injected retrogradely through a drain, while an equivalent amount of normal saline was injected in the IV-TXA alone group. The drain tube was clamped for 2 h in both groups. The amount of wound drainage and transfusion rates were analyzed. Results The drainage volume and duration of drain were significantly lower in the combined group compared with that in the IV-TXA alone group (372.0 ± 129.7 mL vs. 545.2 ± 207.7 mL, P < 0.001;64.7 ± 13.9 h vs. 82.0 ± 12.5 h, P < 0.001). Postoperative length of hospital stay was also significantly shorter in the combined group (6.5 ± 1.51 days vs. 7.95 ± 1.44 days, P < 0.05). Transfusion and complication rates were comparable between the two groups . Conclusions IV injection of TXA combined with retrograde injection of TXA into a drain and clamping it for 2 h could further reduce the total volume of drainage in AIS patients who underwent spinal fusion surgery. Trial registration Chinese Clinical Trial Registry: ChiCTR1900024177, Registered 29 June 2019, http://www.chictr.org.cn/showproj.aspx?proj=40214

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