scholarly journals Comparison of two administration techniques of inhaled nitric oxide on nitrogen dioxide production

1995 ◽  
Vol 42 (10) ◽  
pp. 922-927 ◽  
Author(s):  
Luc Dubé ◽  
Martin Francoeur ◽  
Eric Troncy ◽  
Raymond Carrier ◽  
Gilbert Blaise
Keyword(s):  
Nitric Oxide ◽  
Nitrogen Dioxide ◽  
Inhaled Nitric Oxide

Technical considerations for inhaled nitric oxide therapy: time response to nitric oxide dosing changes and formation of nitrogen dioxide

1997 ◽  
Vol 156 (6) ◽  
pp. 460-462 ◽  
Author(s):  
J. Breuer ◽  
F. Waidelich ◽  
C. Irtel von Brenndorff ◽  
L. Sieverding ◽  
W. Rosendahl ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitrogen Dioxide ◽  
Inhaled Nitric Oxide ◽  
Time Response ◽  
Nitric Oxide Therapy ◽  
Technical Considerations

Exposure of Intensive Care Unit Nurses to Nitric Oxide and Nitrogen Dioxide During Therapeutic Use of Inhaled Nitric Oxide in Adults With Acute Respiratory Distress Syndrome

2003 ◽  
Vol 12 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Mohammed A. Qureshi ◽  
Nipurn J. Shah ◽  
Carol W. Hemmen ◽  
Mary C. Thill ◽  
James A. Kruse
Keyword(s):  
Nitric Oxide ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Nitrogen Dioxide ◽  
Weighted Average ◽  
Inhaled Nitric Oxide ◽  
Breathing Zone ◽  
Mechanical Ventilators ◽  
Time Weighted Average ◽  
Intensive Care Unit Nurses

• Background Although low concentrations of inhaled nitric oxide may by therapeutic, both nitric oxide and its oxidation product nitrogen dioxide are potentially toxic. The threshold limits for time-weighted average concentrations of nitric oxide and nitrogen dioxide issued by the American Conference of Governmental Industrial Hygienists are 25 and 3 ppm, respectively. The concentrations of these gases in the breathing space of hospital personnel during administration of nitric oxide to adult patients have not been reported.• Methods Air was sampled from the breathing zone of intensive care unit nurses via collar-mounted tubes during the nurses’ routine duties attending patients who were receiving inhaled nitric oxide at 5 or 20 ppm. The exhaust ports of the mechanical ventilators were left open to the room. Nitric oxide and nitrogen dioxide were chemically assayed as nitrite from sorbent tubes by using spectrophotometry. Ambient nitric oxide levels were measured at sequential distances from the ventilator by using chemiluminescence.• Results The time-weighted average concentrations of inspired gas for nurses during inhaled nitric oxide treatment were 0.45 ppm or less for nitric oxide and less than 0.29 ppm for nitrogen dioxide. Nitric oxide levels at the ventilator during delivery at 20 ppm were 9.2 ppm, but dropped off markedly beyond 0.6 m (2 ft), to a mean of about 30 ppb.• Conclusion Inhaled nitric oxide therapy at doses up to 20 ppm does not appear to pose a risk of excessive occupational exposure to nitric oxide or nitrogen dioxide to nurses during routine delivery of critical care.

The Pathophysiology of Nitrogen Dioxide During Inhaled Nitric Oxide Therapy

ASAIO Journal ◽  
2017 ◽  
Vol 63 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Priscilla C. Petit ◽  
David H. Fine ◽  
Gregory B. Vásquez ◽  
Lucas Gamero ◽  
Mark S. Slaughter ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitrogen Dioxide ◽  
Inhaled Nitric Oxide ◽  
Nitric Oxide Therapy

Electrochemical nitric oxide and nitrogen dioxide analyzer for use with inhaled nitric oxide

1996 ◽  
Vol 81 (3) ◽  
pp. 1423-1429 ◽  
Author(s):  
L. D. Nelin ◽  
N. T. Christman ◽  
J. F. Morrisey ◽  
C. A. Dawson
Keyword(s):  
Nitric Oxide ◽  
Nitrogen Dioxide ◽  
Good Accuracy ◽  
Clinical Applications ◽  
Inhaled Nitric Oxide ◽  
Constant Flow ◽  
Response Characteristics ◽  
Accuracy And Precision ◽  
O2 Concentration ◽  
Inhaled No

The use of inhaled nitric oxide (NO) in research and clinical applications requires the monitoring of NO and its autooxidation product nitrogen dioxide (NO2) in inspired gas and in the ambient environment. We describe an inexpensive electrochemical NO and NO2 analyzer that uses a critical orifice constant-flow controller and a microprocessor crossover correction for the measurement of NO and NO2 in the concentration range relevant to the use of inhaled NO. The analyzer proved to have good accuracy and precision for NO and NO2 in the range of concentrations relevant to studies of inhaled NO. In this range, the performance was similar to that of a chemiluminescence analyzer, and the response characteristics were not affected by varying the O2 concentration of the mixtures analyzed.

scholarly journals MINIMIZING NITROGEN DIOXIDE EXPOSURE DURING INHALED NITRIC OXIDE THERAPY.2105

1996 ◽  
Vol 39 ◽  
pp. 353-353 ◽  
Author(s):  
Krisa P Van Meurs ◽  
Gregory M Sokol ◽  
Linda L Wright ◽  
Oswaldo Rivera ◽  
William J Thom
Keyword(s):  
Nitric Oxide ◽  
Nitrogen Dioxide ◽  
Inhaled Nitric Oxide ◽  
Nitric Oxide Therapy

Clinical Monitoring of Inhaled Nitric Oxide

PEDIATRICS ◽  
1995 ◽  
Vol 95 (4) ◽  
pp. 620-621
Author(s):  
Philip C. Etches ◽  
Neil N. Finer ◽  
Richard A. Ehrenkranz ◽  
Linda L. Wright
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Hypertension ◽  
Free Radicals ◽  
Respiratory Failure ◽  
Nitrogen Dioxide ◽  
Delivery System ◽  
Weighted Average ◽  
Inhaled Nitric Oxide ◽  
Potential Toxicity ◽  
Time Weighted Average

Inhaled nitric oxide (NO) is being increasingly utilized for the treatment of pulmonary hypertension and ventilation-perfusion mismatch in association with respiratory failure in adults, children, and neonates.1,2 The three major areas of potential toxicity of NO are the formation of methemoglobin, the production of free radicals such as peroxynitrite, and the formation of nitrogen dioxide (NO2) by reaction with oxygen (O2) in the delivery system. NO2 is toxic,3 with a maximum 8-hour, time-weighted, average exposure recommendation of 5 ppm.4

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