scholarly journals The effect of changes in arterial CO2 tension on plasma lidocaine concentration

1987 ◽  
Vol 34 (4) ◽  
pp. 343-345 ◽  
Author(s):  
Christian M. Alexander ◽  
Robert S. Berko ◽  
Jeffrey B. Gross ◽  
David M. Kagle ◽  
Leslie M. Shaw
Keyword(s):  
Lidocaine Concentration ◽  
Plasma Lidocaine ◽  
Plasma Lidocaine Concentration

Changes of Plasma Lidocaine Concentration with Intravenous Injection in General Anesthesia

1998 ◽  
Vol 34 (3) ◽  
pp. 537 ◽  
Author(s):  
Sang Tae Kim ◽  
Jung Won Hwang ◽  
Kyung Hoon Lee ◽  
Ju Hee Kang ◽  
Hyun Moon Baek ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Intravenous Injection ◽  
Lidocaine Concentration ◽  
Plasma Lidocaine ◽  
Plasma Lidocaine Concentration

The Effects of Epidural Insertion Site and Surgical Procedure on Plasma Lidocaine Concentration

2001 ◽  
Vol 92 (2) ◽  
pp. 470-475 ◽  
Author(s):  
Masataka Yokoyama ◽  
Satoshi Mizobuchi ◽  
Osamu Nagano ◽  
Hiromi Fujii ◽  
Masami Yamashita ◽  
...  
Keyword(s):  
Surgical Procedure ◽  
Insertion Site ◽  
Lidocaine Concentration ◽  
Plasma Lidocaine ◽  
Plasma Lidocaine Concentration

The Effects of Epidural Insertion Site and Surgical Procedure on Plasma Lidocaine Concentration

2001 ◽  
pp. 470-475 ◽  
Author(s):  
Masataka Yokoyama ◽  
Satoshi Mizobuchi ◽  
Osamu Nagano ◽  
Hiromi Fujii ◽  
Masami Yamashita ◽  
...  
Keyword(s):  
Surgical Procedure ◽  
Insertion Site ◽  
Lidocaine Concentration ◽  
Plasma Lidocaine ◽  
Plasma Lidocaine Concentration

Plasma lidocaine concentrations after local anesthesia of the groin for cardiac catheterization

2002 ◽  
Vol 57 (3) ◽  
pp. 342-345 ◽  
Author(s):  
Angelika Guth ◽  
Benno Hennen ◽  
Thomas Krämer ◽  
Hans-Peter Stoll ◽  
Michael Böhm
Keyword(s):  
Local Anesthesia ◽  
Cardiac Catheterization ◽  
Plasma Lidocaine

scholarly journals Effect of Injection Pressure of Infiltration Anesthesia to the Jawbone

2016 ◽  
Vol 63 (3) ◽  
pp. 131-138 ◽  
Author(s):  
Kenji Yoshida ◽  
Eri Tanaka ◽  
Hiroyoshi Kawaai ◽  
Shinya Yamazaki
Keyword(s):  
Local Anesthetic ◽  
White Male ◽  
Injection Pressure ◽  
Time Interval ◽  
Time Intervals ◽  
Lidocaine Concentration ◽  
The Mean ◽  
High Concentrations ◽  
Infiltration Anesthesia ◽  
Local Anesthetic Infiltration

To obtain effective infiltration anesthesia in the jawbone, high concentrations of local anesthetic are needed. However, to reduce pain experienced by patients during local anesthetic administration, low-pressure injection is recommended for subperiosteal infiltration anesthesia. Currently, there are no studies regarding the effect of injection pressure on infiltration anesthesia, and a standard injection pressure has not been clearly determined. Hence, the effect of injection pressure of subperiosteal infiltration anesthesia on local anesthetic infiltration to the jawbone was considered by directly measuring lidocaine concentration in the jawbone. Japanese white male rabbits were used as test animals. After inducing general anesthesia with oxygen and sevoflurane, cannulation to the femoral artery was performed and arterial pressure was continuously recorded. Subperiosteal infiltration anesthesia was performed by injecting 0.5 mL of 2% lidocaine containing 1/80,000 adrenaline, and injection pressure was monitored by a pressure transducer for 40 seconds. After specified time intervals (10, 20, 30, 40, 50, and 60 minutes), jawbone and blood samples were collected, and the concentration of lidocaine at each time interval was measured. The mean injection pressure was divided into 4 groups (100 ± 50 mm Hg, 200 ± 50 mm Hg, 300 ± 50 mm Hg, and 400 ± 50 mm Hg), and comparison statistical analysis between these 4 groups was performed. No significant change in blood pressure during infiltration anesthesia was observed in any of the 4 groups. Lidocaine concentration in the blood and jawbone were highest 10 minutes after the infiltration anesthesia in all 4 groups and decreased thereafter. Lidocaine concentration in the jawbone increased as injection pressure increased, while serum lidocaine concentration was significantly lower. This suggests that when injection pressure of subperiosteal infiltration anesthesia is low, infiltration of local anesthetic to the jawbone may be reduced, while transfer to oral mucosa and blood may be increased.

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