scholarly journals Cerebral vascular responses to ketamine and thiopentone during foetal acidosis

Author(s):  
Brian G. Pickering ◽  
Richard J. Palahniuk ◽  
Jacques Coté ◽  
John G. Wade ◽  
Michael G. Pash
1983 ◽  
Vol 27 (4) ◽  
pp. 226
Author(s):  
B. G. PICKERING ◽  
R. J. PALAHNIUK ◽  
J. COT?? ◽  
J. G. WADE ◽  
M. G. PASH

1983 ◽  
Vol 3 (1) ◽  
pp. 21
Author(s):  
B. G. Pickering ◽  
R. J. Palahniuk ◽  
J. Cote ◽  
J. G. Wade ◽  
M. G. Pash ◽  
...  

Stroke ◽  
1991 ◽  
Vol 22 (6) ◽  
pp. 790-796 ◽  
Author(s):  
F M Faraci ◽  
A G Lopez ◽  
K Breese ◽  
M L Armstrong ◽  
D D Heistad

1995 ◽  
Vol 268 (5) ◽  
pp. H1884-H1890 ◽  
Author(s):  
H. Parfenova ◽  
S. Zuckerman ◽  
C. W. Leffler

The present study addresses the hypothesis that indomethacin, in addition to blocking prostaglandin synthesis, directly inhibits prostacyclin receptor-mediated cerebral vascular responses. To test this hypothesis, the effects of indomethacin on pial arteriolar dilation in response to the prostacyclin receptor agonist iloprost were investigated using a cranial window technique in newborn pigs. Topically applied iloprost resulted in dose-dependent pial arteriolar dilation and concomitant increases in cortical adenosine 3',5'-cyclic monophosphate (cAMP). Indomethacin (5 mg/kg iv + 10(-4) M topically) greatly reduced both the vasodilation and the increase in cortical cAMP in response to iloprost. In contrast, indomethacin did not attenuate beta-adrenoreceptor-mediated vasodilation and the increase in cortical cAMP in response to isoproterenol. Aspirin (50 mg/kg iv + 10(-3) M topically) did not affect pial arteriolar dilation or the increase in cortical cAMP in response to iloprost. Unlike indomethacin, aspirin was not effective in inhibiting prostanoid-associated cerebral vasodilation and increase in cortical cAMP in response to hypercapnia. The present data suggest that indomethacin selectively inhibits prostacyclin receptor-mediated responses in the newborn pig cerebral circulation. The combination of highly effective inhibition of prostaglandin H synthase and prostacyclin receptor-mediated vasodilation may contribute to the increased efficacy of indomethacin compared with other prostaglandin H synthase inhibitors in blocking certain vasodilator responses associated with prostanoids.


1989 ◽  
Vol 25 (2) ◽  
pp. 180-183 ◽  
Author(s):  
Donathan G Beasley ◽  
David W Busija ◽  
William M Armstead ◽  
Robert Mirro

Neonatology ◽  
2003 ◽  
Vol 84 (2) ◽  
pp. 115-118 ◽  
Author(s):  
Anne Koons ◽  
Thomas Hegyi ◽  
Rajeev Mehta ◽  
Mark Hiatt ◽  
Barry Weinberger

1979 ◽  
Vol 44 (2) ◽  
pp. 288-294 ◽  
Author(s):  
P M Gross ◽  
D D Heistad ◽  
M R Strait ◽  
M L Marcus ◽  
M J Brody

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