scholarly journals Myocardial contractility and ischaemia in the isolated perfused rat heart with propofol and thiopentone

1991 ◽  
Vol 38 (5) ◽  
pp. 634-639 ◽  
Author(s):  
B. P. Kavanagh ◽  
M. P. Ryan ◽  
A. J. Cunningham
Keyword(s):  
Rat Heart ◽  
Myocardial Contractility ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart

Reversible impairment of myocardial contractility due to hypercarbic acidosis in the isolated perfused rat heart

1991 ◽  
Vol 19 (2) ◽  
pp. 218-224 ◽  
Author(s):  
WANCHUN TANG ◽  
MAX HARRY WEIL ◽  
RAÜL J. GAZMURI ◽  
JOE BISERA ◽  
ERIC C. RACKOW
Keyword(s):  
Rat Heart ◽  
Myocardial Contractility ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart

Location of epicardial pacemaker electrodes and myocardial contractility

1969 ◽  
Vol 47 (3) ◽  
pp. 267-271 ◽  
Author(s):  
G. M. Tremblay ◽  
M. Nahas
Keyword(s):  
Rat Heart ◽  
Myocardial Contractility ◽  
Calcium Concentration ◽  
Cardiac Contractility ◽  
Sprague Dawley ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Sprague Dawley Rats ◽  
Significant Difference ◽  
Pacemaker Electrodes

Effects of pacing from different epicardial sites on cardiac contractility were studied in the isolated perfused rat heart. An indwelling balloon containing a known volume of saline was used to record intracavitary pressure (LVP), force, and maximum dp/dt during isovolumic paced contraction. Coronary flow was kept constant, and the adequacy of oxygenation was verified by lactate extraction. Forty male Sprague–Dawley rats weighing 250–300 g were divided into two groups, according to the rate of pacing, and stimulated. Pacing from four different epicardial sites failed to show any statistically significant difference in LVP, force, or maximum dp/dt at either different heart rate or calcium concentration. The present study suggests that myocardial contractility in the isolated perfused rat heart is not affected by the pacing site of the epicardial pacemaker.

Myocardial Contractility. II. Effect of Changes in Cardiac Function on the Subcellular Distribution of Calcium in the Isolated Perfused Rat Heart

1972 ◽  
Vol 50 (9) ◽  
pp. 853-859 ◽  
Author(s):  
Charles W. Tomlinson ◽  
Naranjan S. Dhalla
Keyword(s):  
Heart Rate ◽  
Subcellular Distribution ◽  
Rat Heart ◽  
Myocardial Contractility ◽  
Contractile Force ◽  
Tissue Homogenate ◽  
Perfusion Medium ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Frequency Of Stimulation

The effects of changes in heart rate and contractile force due to electrical stimulation, alteration of the temperature of the perfusion medium, and varying degrees of stretch tension on the subcellular distribution of calcium in the isolated perfused rat heart were studied. Increasing the frequency of stimulation from 80 to 320 pulses/min decreased myocardial contractility without appreciable changes in the levels of calcium in the tissue homogenate and heavy microsomal (8000 – 40 000 × g) fraction. On the other hand, mitochondrial (800–8000 × g) calcium content was greater in hearts stimulated at 120 pulses/min than in hearts stimulated at 80 pulses/min; further increase in the frequency of stimulation resulted in a decrease in the level of mitochondrial calcium. Increasing the temperature of the perfusion medium from 25 to 37 °C increased the heart rate and decreased the contractile force without any changes in the levels of calcium in the homogenate or subcellular fractions. Increasing the stretch tension on the hearts from 0 to 5 g increased the developed contractile force and the level of heavy microsomal calcium without changing the heart rate or the levels of calcium in the homogenate and mitochondria. The results do not reveal any cause–effect relationship between changes in heart function and subcellular distribution of calcium.

Global ischemic duration and reperfusion function in the isolated perfused rat heart

Resuscitation ◽  
2004 ◽  
Vol 62 (1) ◽  
pp. 97-106 ◽  
Author(s):  
Brian S. Palmer ◽  
Mersiha Hadziahmetovic ◽  
Timothy Veci ◽  
Mark G. Angelos
Keyword(s):  
Rat Heart ◽  
Perfused Rat Heart ◽  
Isolated Perfused Rat Heart ◽  
Ischemic Duration
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