The effect of the oral administration of bile salts on the composition of human fistula bile

1937 ◽  
Vol 4 (5) ◽  
pp. 306-312 ◽  
Author(s):  
K. G. Kohlstaedt ◽  
O. M. Helmer
Keyword(s):  
Oral Administration ◽  
Bile Salts ◽  
Fistula Bile

scholarly journals Isolation, Identification and Function of Pichia anomala AR2016 and Its Effects on the Growth and Health of Weaned Pigs

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1179
Author(s):  
Yajun Ma ◽  
Zhihong Sun ◽  
Yan Zeng ◽  
Ping Hu ◽  
Weizhong Sun ◽  
...  
Keyword(s):  
Oral Administration ◽  
Relative Abundance ◽  
Bile Salts ◽  
Average Daily Gain ◽  
Pichia Anomala ◽  
Simulated Gastric Fluid ◽  
Transferase Activity ◽  
Mrna Levels ◽  
Weaned Pigs ◽  
Intestinal Juice

This study isolates and identifies Pichia anomala (P. anomala) AR2016, and studies its effect on the growth and health of weaned pigs. A P. anomala strain from solid wine koji is isolated and identified using 26S rDNA analysis, and its culture conditions are optimized. Heat tolerance, bile salt tolerance, artificial gastric, and intestinal juice tolerance are evaluated. In our methodology, thirty 28 d Large White × Landrace × Rongchang weaned pigs were randomly divided into three groups with 10 barrows in each, and fed a maize-soybean meal diet and orally administered 0.85% saline (CK), 1 mL 1 × 109 cfu/mL Candida utilis (C. utilis), and 1 mL 1 × 109 cfu/mL P. anomala once daily for 28 days. A P. anomala strain was identified and named P. anomala AR2016. P. anomala AR2016 grew best in yeast extract peptone dextrose medium with pH 5.0 at 28 °C, 180 r/min and could tolerate 45 °C for 0.5 h, 0.2% pig bile salts, simulated gastric fluid, and 1.0% simulated intestinal fluid. Our results show that compared with the CK group, orally administered P. anomala AR2016 increases average daily gain, the ileal villus height, the ileal mucosal concentrations of occludin and zonula occluens-1, the serum glucose and total protein concentration, total superoxide dismutase, glutathione peroxidase, and total antioxidative capacity activity, the trypsin and lipase activity in jejunal and ileal contents, the jejunal and ileal mucosa mRNA levels of ALP, TNF-α, and TLR-2, and the relative abundance of Bacteroidetes, Actinobacteria, Succinivibrionaceae, Lachnospiraceae, and Prevotellaceae (p < 0.05). Compared with the CK group, oral administration of P. anomala AR2016 decreased the incidence of diarrhea, aspartate aminotransferase activity, alanine amino-transferase-activity, malondialdehyde, D-lactic acid and endotoxin content in serum, the mRNA level of aminopeptidase N of ileum mucosa, and the relative abundance of Proteobacteria, Clostridiaceae, Campylobacteraceae, Vibrionaceae, Bacillus, and Pseudon (p < 0.05). Collectively, the study indicates that P. anomala AR2016 can tolerate high acidity and high bile salts, and has high survivability in the artificial gastric intestinal juice environment. Oral administration of P. anomala AR2016 improves the growth performance, reduces the incidence of diarrhea, enhances intestinal barrier function, and improves microflora in weaned pigs.

Effects of bile salts on the lovastatin pharmacokinetics following oral administration to rats

Drug Delivery ◽  
2010 ◽  
Vol 18 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Kyunghee Kim ◽  
Inkyung Yoon ◽  
Inkoo Chun ◽  
Nayoung Lee ◽  
Taekrho Kim ◽  
...  
Keyword(s):  
Oral Administration ◽  
Bile Salts

The Biological Importance of Bile Salts

1979 ◽  
Vol 7 (6) ◽  
pp. 1323-1323
Author(s):  
H. DANIELSSON
Keyword(s):  
Bile Salts ◽  
Biological Importance
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