Age-related changes of the [11C]CFT binding to the striatal dopamine transporters in the fischer 344 rats: a PET study

2003 ◽  
Vol 17 (3) ◽  
pp. 249-253 ◽  
Author(s):  
Kazunori Kawamura ◽  
Keiichi Oda ◽  
Kiichi Ishiwata
1994 ◽  
Vol 111 (6) ◽  
pp. 799-806 ◽  
Author(s):  
Meiho Nakayama ◽  
Robert H. Helfert ◽  
Horst R. Konrad ◽  
Donald M. Caspary

An ultrastructural study was performed to assets age-related changes in the vestibular end organs of Fischer 344 rats. The surfaces of the maculae and cristae from 3-, 12-, and 24-month-old Fischer 344 rats were observed by use of scanning electron microscopy. Age-related changes in the morphology of the vestibular neuroepithelium included a substantial loss of hair cells, as well as a reduction in the number of kinocllia and stereocilla on those that remained. These changes were greatest in the central upper regions of the three ampullae. In aged animals a greater area of the neuroepithelial surface was covered with microvilli, and in some instances, giant cilia were found among the microvillous surfaces. In contrast, there were few differences among the three age groups in the number and condition of hair cells in the saccules and utricles. The changes observed in the cristae may contribute to the age-associated impairment of vestibular function. If similar changes occur in human beings, these could in part account for the presbycusis observed in the elderly.


Pteridines ◽  
1991 ◽  
Vol 3 (1-2) ◽  
pp. 65-66
Author(s):  
Y. Tani ◽  
T. Ohno ◽  
T. Ishihara ◽  
T. Kanai ◽  
T. Noguchi

2016 ◽  
Vol 9 (4) ◽  
pp. 352-357 ◽  
Author(s):  
Min-Kwan Baek ◽  
Kyung-Ok Kim ◽  
Hyun-Jin Kwon ◽  
Yong-Woo Kim ◽  
Joo-Hyun Woo ◽  
...  

1989 ◽  
Vol 49 ◽  
pp. 267
Author(s):  
Yutaka Nakagawa ◽  
Akira Yamazaki ◽  
Tsuyoshi Ishima ◽  
Masaru Tamura ◽  
Takashi Ogasawara ◽  
...  

Aging Cell ◽  
2005 ◽  
Vol 4 (3) ◽  
pp. 139-145 ◽  
Author(s):  
R. LaFrance ◽  
N. Brustovetsky ◽  
C. Sherburne ◽  
D. DeLong ◽  
J. M. Dubinsky

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