Red blood cell mechanics and capillary blood rheology

1991 ◽  
Vol 18 (3) ◽  
pp. 231-251 ◽  
Author(s):  
T. W. Secomb
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Mechanics ◽  
Blood Rheology ◽  
Capillary Blood

A Fluid Structure Interaction Model for the Red Blood Cell Mechanics

2016 ◽  
Vol 5 (6) ◽  
pp. 524-528
Author(s):  
Alireza Karimi ◽  
Kamran Hassani ◽  
Ali Tavakoli Golpaygani ◽  
Farhad Izadi
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Mechanics ◽  
Fluid Structure Interaction ◽  
Interaction Model ◽  
Fluid Structure ◽  
Structure Interaction

Effects of hydration and dehydration on blood rheology in sickle cell trait carriers during exercise

2010 ◽  
Vol 299 (3) ◽  
pp. H908-H914 ◽  
Author(s):  
Julien Tripette ◽  
Gylna Loko ◽  
Abdoulaye Samb ◽  
Bertin Doubi Gogh ◽  
Estelle Sewade ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Cell ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Blood Viscosity ◽  
Sickle Cell Trait ◽  
Blood Rheology ◽  
Plasma Viscosity ◽  
Adequate Hydration ◽  
Cont Group

This study compared the hemorheological responses of a group of sickle cell trait (SCT) carriers with those of a control (Cont) group in response to 40 min of submaximal exercise (exercise intensity, 55% aerobic peak power) performed in two conditions: one with water offered ad libitum, i.e., the hydration (Hyd) condition, and one without water, i.e., the dehydration (Dehyd) condition. Blood and plasma viscosities, as well as red blood cell rigidity, were determined at rest, at the end of exercise, and at 2 h recovery with a cone plate viscometer at high shear rate and 37°C. The SCT and Cont groups lost 1 ± 0.7 and 1.6 ± 0.6 kg of body weight, respectively, in the Dehyd condition, indicating a significant effect of water deprivation compared with the Hyd condition, in which body weight remained unchanged. Plasma viscosity increased with exercise and returned to baseline during recovery independently of the group and condition. As previously demonstrated, resting blood viscosity was greater in the SCT carriers than in the Cont group. Blood viscosity increased by the end of exercise and returned to baseline at 2 h recovery in the Cont group in both conditions. The blood viscosity of SCT carriers did not change in response to exercise in the Dehyd condition and remained elevated at 2 h recovery. This extended hyperviscosity, in association with other biological changes induced by exercise, could be considered as a risk factor for exercise-related events in SCT carriers, similar to vasoocclusive crises, notably during the recovery. In contrast, the Hyd condition normalized the hyperviscosity and red blood cell rigidity of the SCT carriers, with blood viscosity values reaching the same lower values as those found in the Cont group during the recovery. Adequate hydration of SCT carriers should be strongly promoted to reduce the clinical risk associated with potential hyperviscosity complications.

scholarly journals Accounting for residence-time in blood rheology models: do we really need non-Newtonian blood flow modelling in large arteries?

2018 ◽  
Vol 15 (146) ◽  
pp. 20180486 ◽  
Author(s):  
Amirhossein Arzani
Keyword(s):  
Experimental Data ◽  
Blood Cell ◽  
Residence Time ◽  
Red Blood Cell ◽  
Blood Rheology ◽  
Shear Thinning ◽  
Patient Specific ◽  
Large Artery ◽  
Newtonian Model ◽  
Rouleaux Formation

Patient-specific computational fluid dynamics (CFD) is a promising tool that provides highly resolved haemodynamics information. The choice of blood rheology is an assumption in CFD models that has been subject to extensive debate. Blood is known to exhibit shear-thinning behaviour, and non-Newtonian modelling has been recommended for aneurysmal flows. Current non-Newtonian models ignore rouleaux formation, which is the key player in blood's shear-thinning behaviour. Experimental data suggest that red blood cell aggregation and rouleaux formation require notable red blood cell residence-time (RT) in a low shear rate regime. This study proposes a novel hybrid Newtonian and non-Newtonian rheology model where the shear-thinning behaviour is activated in high RT regions based on experimental data. Image-based abdominal aortic and cerebral aneurysm models are considered and highly resolved CFD simulations are performed using a minimally dissipative solver. Lagrangian particle tracking is used to define a backward particle RT measure and detect stagnant regions with increased rouleaux formation likelihood. Our novel RT-based non-Newtonian model shows a significant reduction in shear-thinning effects and provides haemodynamic results qualitatively identical and quantitatively close to the Newtonian model. Our results have important implications in patient-specific CFD modelling and suggest that non-Newtonian models should be revisited in large artery flows.

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