Long-term effects of alpha-interferon for treatment of chronic hepatitis C in terms of histological changes with aminotransferase normalization and hepatitis C virus RNA seroconversion

1993 ◽  
Vol 28 (S5) ◽  
pp. 115-117 ◽  
Author(s):  
Kazuhiko Hosoda ◽  
Osamu Yokosuka ◽  
Naoya Kato ◽  
Yoshimi Ito ◽  
Masao Ohto ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Alpha Interferon ◽  
Long Term Effects ◽  
Hepatitis C Virus Rna ◽  
Histological Changes ◽  
Virus Rna

Earlier loss of hepatitis C virus RNA in interferon therapy can predict a long-term response in chronic hepatitis C

1997 ◽  
Vol 12 (6) ◽  
pp. 468-472 ◽  
Author(s):  
SHINICHI KAKUMU ◽  
TOSHIYUKI AIYAMA ◽  
AKIHIKO OKUMURA ◽  
KAZUO IWATA ◽  
TETSUYA ISHIKAWA ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Interferon Therapy ◽  
Hepatitis C Virus Rna ◽  
Virus Rna ◽  
Term Response

scholarly journals Delayed Viral Clearance after 6-Week Treatment with Peginterferon Plus Ribavirin in a Patient with Chronic Hepatitis C Virus Genotype 1b

2016 ◽  
Vol 10 (2) ◽  
pp. 417-422 ◽  
Author(s):  
Akira Sato ◽  
Toshiya Ishii ◽  
Kayo Adachi ◽  
Hideaki Takahashi ◽  
Fumiaki Sano ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Clearance ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Virus Rna ◽  
Virus Genotype ◽  
Virus Rna ◽  
Chronic Hepatitis C Virus

Following interferon-based therapy for chronic hepatitis C, the negativity of hepatitis C virus RNA is essential to achieve viral clearance at the end of treatment. We report a case of clearance of chronic hepatitis C virus infection following early discontinuation (at 6 weeks) of peginterferon plus ribavirin therapy, without negativity for hepatitis C virus RNA during the treatment period. The patient was a 76-year-old Japanese male infected with hepatitis C virus genotype 1b and TT of IL28B rs8099917. Hepatitis C virus RNA remained positive at persistently low levels for more than 2 months after the cessation of therapy and became negative at 7 months after the discontinuation of therapy. Spontaneous clearance of hepatitis C virus RNA can occur following antiviral failure in patients with persistently low viral loads, and virological follow-up is therefore necessary in chronic hepatitis C virus infection, even after antiviral failure.

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