Alterations ofc-fos mRNA expression in hypothalamic-pituitary-adrenal axis and various brain regions induced by intrathecal single and repeated substance P administrations in mice

2004 ◽  
Vol 27 (8) ◽  
pp. 863-866 ◽  
Author(s):  
Seong-Soo Choi ◽  
Han-Kyu Lee ◽  
Eon-Jeong Shim ◽  
Min-Soo Kwon ◽  
Young-Jun Seo ◽  
...  
Keyword(s):  
Substance P ◽  
Mrna Expression ◽  
Brain Regions ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Pituitary Adrenal Axis

scholarly journals Repeated Ferret Odor Exposure Induces Different Temporal Patterns of Same-Stressor Habituation and Novel-Stressor Sensitization in Both Hypothalamic-Pituitary-Adrenal Axis Activity and Forebrain c-fos Expression in the Rat

Endocrinology ◽  
2009 ◽  
Vol 150 (2) ◽  
pp. 749-761 ◽  
Author(s):  
Marc S. Weinberg ◽  
Aadra P. Bhatt ◽  
Milena Girotti ◽  
Cher V. Masini ◽  
Heidi E. W. Day ◽  
...  
Keyword(s):  
Hpa Axis ◽  
Rapid Development ◽  
Brain Regions ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Repeated Exposure ◽  
Early Gene ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Psychological Stressor ◽  
Pituitary Adrenal Axis

Repeated exposure to a moderately intense stressor typically produces attenuation of the hypothalamic-pituitary-adrenal (HPA) axis response (habituation) on re-presentation of the same stressor; however, if a novel stressor is presented to the same animals, the HPA axis response may be augmented (sensitization). The extent to which this adaptation is also evident within neural activity patterns is unknown. This study tested whether repeated ferret odor (FO) exposure, a moderately intense psychological stressor for rats, leads to both same-stressor habituation and novel-stressor sensitization of the HPA axis response and neuronal activity as determined by immediate early gene induction (c-fos mRNA). Rats were presented with FO in their home cages for 30 min a day for up to 2 wk and subsequently challenged with FO or restraint. Rats displayed HPA axis activity habituation and widespread habituation of c-fos mRNA expression (in situ hybridization) throughout the brain in as few as three repeated presentations of FO. However, repeated FO exposure led to a more gradual development of sensitized HPA-axis and c-fos mRNA responses to restraint that were not fully evident until after 14 d of prior FO exposure. The sensitized response was evident in many of the same brain regions that displayed habituation, including primary sensory cortices and the prefrontal cortex. The shared spatial expression but distinct temporal development of habituation and sensitization neural response patterns suggests two independent processes with opposing influences across overlapping brain systems. Repeated exposure of rats to ferret odor leads to rapid development of stimulus-specific habituation and slower development of novel-stressor sensitization of forebrain and hypothalamic-pituitary-adrenal axis activity.

Calcitonin gene expression induced by lipopolysaccharide in the rat pituitary

2002 ◽  
Vol 282 (6) ◽  
pp. E1380-E1384 ◽  
Author(s):  
Yoshimitsu Kiriyama ◽  
Yasuyuki Nomura ◽  
Yukiko Tokumitsu
Keyword(s):  
Gene Expression ◽  
Bacterial Infection ◽  
Mrna Expression ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Precursor Protein ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Calcitonin Gene ◽  
Rat Pituitary ◽  
Pituitary Adrenal Axis

Procalcitonin (PCT), the precursor protein of calcitonin (CT), has been considered recently as a significant indicator of bacterial infection and sepsis. However, the major source of PCT in sepsis remains unclear. The hypothalamic-pituitary-adrenal axis is activated during sepsis. Moreover, immunoreactive CT (iCT) can be detected in the pituitary. Therefore, we examined the effects of lipopolysaccharide (LPS) administration on CT mRNA expression in the pituitary. After administration of LPS, CT mRNA expression in the pituitary was increased significantly. The increase of CT mRNA was associated with significant elevations of the iCT levels in the serum. These results imply that the pituitary is one of the sources of the serum PCT during sepsis.

Sign in / Sign up

Export Citation Format

Share Document