Protective effects of Vitamin C on cisplatin nephrotoxicity

1994 ◽  
Vol 17 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Se-Young Choung ◽  
Jae-Myeong Kong
Keyword(s):  
Vitamin C ◽  
Protective Effects ◽  
Cisplatin Nephrotoxicity

scholarly journals The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19

Diseases ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 46
Author(s):  
Feng Xu ◽  
Yawei Wen ◽  
Xinge Hu ◽  
Tiannan Wang ◽  
Guoxun Chen
Keyword(s):  
Vitamin C ◽  
Distress Syndrome ◽  
Kidney Injury ◽  
Mortality Rates ◽  
Protective Effects ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Renal Functions ◽  
Potential Use

The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mortality rates. One main feature of COVID-19 is the cytokine storm, which can cause damage in cells and tissues including the kidneys. Here, we reviewed the current literature on renal impairments in patients with COVID-19 and analyzed the possible etiology and mechanisms. In addition, we investigated the potential use of vitamin C for the prevention of renal injury in those patients. It appears that vitamin C could be helpful to improve the outcomes of patients with COVID-19. Lastly, we discussed the possible protective effects of vitamin C on renal functions in COVID-19 patients with existing kidney conditions.

PROTECTIVE EFFECTS OF VITAMIN C AGAINST CISPLATIN-INDUCED NEPHROTOXICITY AND LIPID PEROXIDATION IN ADULT RATS: A DOSE-DEPENDENT STUDY

2000 ◽  
Vol 41 (4) ◽  
pp. 405-411 ◽  
Author(s):  
LUSÂNIA M. GREGGI ANTUNES ◽  
JOANA D'ARC C. DARIN ◽  
MARIA DE LOURDES P. BIANCHI
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Protective Effects ◽  
Adult Rats ◽  
Dose Dependent

Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B1 in cultured human lymphocytes

2009 ◽  
Vol 25 (3) ◽  
pp. 183-188 ◽  
Author(s):  
L Alpsoy ◽  
G Agar ◽  
M Ikbal
Keyword(s):  
Vitamin A ◽  
Vitamin C ◽  
Human Lymphocytes ◽  
Mutagenic Effect ◽  
Treated Group ◽  
Protective Role ◽  
Effective Concentration ◽  
Dependent Manner ◽  
Protective Effects ◽  
Aflatoxin B

In this study, we aimed to evaluate the effect of vitamins A, C, and E against aflatoxin B1 (AFB1) on blood cultures in relation to induction of sister chromatid exchange (SCE). The results indicated genotoxic and mutagenic damage in cultured human lymphocytes exposed to AFB1. The results showed that 5 μM concentration of AFB1 increased SCE. When vitamins A, C, and E were added to AFB1, the frequency of SCE decreased. These results suggest that vitamins A, C, and E could effectively inhibit AFB1-induced SCE, which may partially responsible for its mutagenic effect of AFB1. Besides, the protective effect of vitamins A, C, and E against AFB1 was increased in a dose-dependent manner (i.e., as the doses increased, their protective effects also increased). There was a significant decrease in the SCE frequency in AFB1-treated group compared with the groups receiving AFB1 and also vitamins A, C, and E. The most effective concentration was 100 microM vitamin C, and the lowest effective concentration was 0.5 microM vitamin A. Vitamin C has the most effective concentration of 100 μM, and vitamin A has the lowest effective concentration of 0.5 μM. The order of the decreasing effect of the SCE frequency of vitamins was as follows: vitamin C > vitamin E > vitamin A.

scholarly journals Effect of vitamin C supplementation on hematological parameters in smokeless tobacco chewers

2021 ◽  
Vol 12 (3) ◽  
pp. 2088-2094
Author(s):  
Jaywant S. Thorat ◽  
Anand G. Joshi ◽  
Kanchan C. Wingkar
Keyword(s):  
Platelet Count ◽  
Vitamin C ◽  
Smokeless Tobacco ◽  
Hematological Parameters ◽  
Protective Effects ◽  
Baseline Study ◽  
Vitamin C Supplementation ◽  
Baseline Values ◽  
Wbc Count ◽  
Rbc Count

The present study was aimed to evaluate the effect of Vitamin C (VC) supplementation on hematological parameters in Smokeless Tobacco (ST) chewers.  A total of 338 subjects aged between 31 to 60 years (168 ST chewers and 170 ST non-chewers) participated in the present study. ST chewers were further divided into 3 subgroups with respect to ST chewing duration in years. Subjects of both the groups were examined at the baseline study and after 45 days of supplementation of 1 g of Vitamin C (VC) for hematological parameters.  WBC count (p=0.04), granulocytes % (p=0.0007), HCT (p=0.01) and MCV (p=0.04) were significantly increased whereas, monocytes % (p=0.002) and platelet count (p<0.0001) were significantly decreased in ST chewers as compared to controls. After supplementation of VC, WBC count (p<0.001) and granulocytes % (p<0.0001) were significantly decreased and lymphocytes % (p=0.008), monocytes % (p<0.0001), RBC count (p=0.01) and Hb content (p=0.006) were significantly increased in ST chewers as compared to their baseline values. In conclusion,  the use of ST had deleterious effects on hematological parameters; however, supplementation of 1 g of VC showed protective effects on hematological parameters.

Hepatotoxicity and nephrotoxicity in rats induced by carbon tetrachloride and the protective effects of Teucrium polium and vitamin C

2019 ◽  
Vol 29 (5) ◽  
pp. 313-321 ◽  
Author(s):  
Fatma Rahmouni ◽  
Riadh Badraoui ◽  
Nahed Amri ◽  
Aïda Elleuch ◽  
Abdelfattah El-Feki ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Vitamin C ◽  
Protective Effects ◽  
Teucrium Polium

scholarly journals A New Mechanism of Vitamin C Effects on A/FM/1/47(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Ying Cai ◽  
Yi-Fang Li ◽  
Lu-Ping Tang ◽  
Bun Tsoi ◽  
Min Chen ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Vitamin C ◽  
H1n1 Virus ◽  
Influenza Infection ◽  
Signal Transduction Pathway ◽  
Type I Interferons ◽  
Type I ◽  
Protective Effects ◽  
Mitochondrial Antiviral Signaling ◽  
Influenza Viral Infection

It is well known that vitamin C could protect against influenza infection, but little is known about the mechanisms. This study aimed to investigate the influence and possible mechanisms of vitamin C on pneumonia induced by influenza virus in stressed mice. Results showed that restraint stress significantly increased the mortality and the severity of pneumonia in mice caused by A/FM/1/47(H1N1) virus infection, which was attenuated by oral administration of vitamin C (125 and 250 mg/kg). Moreover, vitamin C administration significantly decreased expression of susceptibility genes, including mitochondrial antiviral signaling (MAVS) and interferon regulatory factor 3 (IRF3), and increased expression of NF-κB. These work in conjunction to induce type I interferons (IFNs) and elicit innate antiviral response as key factors in RIG-I-mediated signal transduction pathway. The above effects of vitamin C were further found to relate with inhibition of excess CORT synthesis by regulating steroid hydroxylating enzymes in adrenal gland. In conclusion, the protective effects of vitamin C on influenza virus-caused pneumonia might be related to its inhibition of CORT synthesis, which reduces the susceptibility to influenza viral infection in restraint-stressed mice. These findings provide a new mechanism for the effects of vitamin C on influenza virus-induced pneumonia in restraint-stressed mice.

Protective effects of cysteine, methionine and vitamin C on the stomach in chronically alcohol treated rats

2008 ◽  
Vol 28 (5) ◽  
pp. 591-598 ◽  
Author(s):  
Ramazan Amanvermez ◽  
Özgür K. Tunçel ◽  
Şerif Demir ◽  
Mehmet Kefeli ◽  
Yüksel Bek ◽  
...  
Keyword(s):  
Vitamin C ◽  
Protective Effects
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