Evaluation of the immune response following exposure of mice to bisphenol A: Induction of th1 cytokine and prolactin by BPA exposure in the mouse spleen cells

2002 ◽  
Vol 25 (6) ◽  
pp. 946-953 ◽  
Author(s):  
Ji -Youn Youn ◽  
Hyo -Young Park ◽  
Jung -Won Lee ◽  
In -Ok Jung ◽  
Keum -Hwa Choi ◽  
...  
Keyword(s):  
Immune Response ◽  
Bisphenol A ◽  
Mouse Spleen ◽  
Spleen Cells ◽  
Th1 Cytokine

scholarly journals ANTIBODY-MEDIATED SUPPRESSION OF THE IMMUNE RESPONSE IN VITRO

1970 ◽  
Vol 131 (2) ◽  
pp. 247-274 ◽  
Author(s):  
Marc Feldmann ◽  
Erwin Diener
Keyword(s):  
Immune Response ◽  
Immune Suppression ◽  
Serum Antibody ◽  
Cellular Level ◽  
Mouse Spleen ◽  
Spleen Cells ◽  
Normal Response ◽  
In Vitro Immune Response ◽  
Immune Response In Vitro

Antibody-mediated suppression of the in vitro immune response to polymerized flagellin of Salmonella adelaide and to sheep erythrocytes was studied at the cellular level. Normal mouse spleen cells, preincubated in vitro with mixtures of antigen and antibody for short periods of time before being washed, did not respond to an optimal antigenic challenge in vitro, whereas similar cells treated with antibody alone gave a normal response. The degree of immune suppression was found to depend on the time of preincubation. Significant immune suppression could be induced in as short a time as 15 min, whereas profound suppression (90%) required the incubation of cells with mixtures of antigen and antibody for 4–6 hr. Mouse spleen cells treated similarly were also unable to respond subsequently to the antigen upon transfer to lethally irradiated hosts, as measured at both the level of the antigen-reactive cell and that of serum antibody production. These results were taken as evidence that in vitro an effect of antibody-mediated suppression occurred at the level of the immunocompetent cell. Similarities between immune tolerance and antibody-mediated suppression in vitro were described, and the significance of the findings discussed in the light of current concepts of the mechanism of antibody-mediated suppression.

scholarly journals DELETION OF HAPTEN-BINDING CELLS BY A HIGHLY RADIOACTIVE 125I CONJUGATE

1972 ◽  
Vol 136 (2) ◽  
pp. 305-317 ◽  
Author(s):  
Dov Theo Golan ◽  
Yves Borel
Keyword(s):  
Immune Response ◽  
Normal Mouse ◽  
Mouse Spleen ◽  
Spleen Cells ◽  
Protein Carrier

Exposure of normal mouse spleen cells in vitro to highly 125I-labeled dinitrophenyl (DNP)-protein carrier conjugates specifically inactivated cells able to mount an immune response to that hapten after in vivo challenge. The deletion was hapten specific and independent of the radioactive carrier to which the hapten was bound. DNP-binding cells were inactivated by radioactivity that was not part of the hapten, but was solely confined to the carrier moiety. The deletion of the anti-DNP response lasted 2–3 wk and could be specifically inhibited.

scholarly journals EFFECTS OF HYDROCORTISONE ON THE IN VITRO PRIMARY IMMUNE RESPONSE OF MOUSE SPLEEN CELLS TO SHEEP ERYTHROCYTES

1972 ◽  
Vol 25 (5) ◽  
pp. 345-353 ◽  
Author(s):  
MASANOBU SUGIMOTO ◽  
SHIN-ICHI TAMURA ◽  
TAKESHI KURATA ◽  
YASUYUKI EGASHIRA
Keyword(s):  
Immune Response ◽  
Primary Immune Response ◽  
Mouse Spleen ◽  
Spleen Cells ◽  
Sheep Erythrocytes
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