Evidence for a common molecular basis for sequence recognition of N3-guanine and N3-adenine DNA adducts involving the covalent bonding reaction of (+)-CC-1065

2002 ◽  
Vol 25 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Hyun-Ju Park
Keyword(s):  
Dna Adducts ◽  
Molecular Basis ◽  
Covalent Bonding ◽  
Sequence Recognition ◽  
Common Molecular Basis

Identifying the causative proteins of similar side effect pairs to explore the common molecular basis of these side effects

2015 ◽  
Vol 11 (7) ◽  
pp. 2060-2067
Author(s):  
Yunfeng Wang ◽  
Xiujie Chen ◽  
Lei Liu ◽  
Yuelong Chen ◽  
Hongzhe Ma ◽  
...  
Keyword(s):  
Public Health ◽  
Side Effects ◽  
Molecular Basis ◽  
Health Concern ◽  
Drug Side Effects ◽  
Drug Reactions ◽  
Public Health Concern ◽  
The Common ◽  
Development Failure ◽  
Common Molecular Basis

Drug side effects, or adverse drug reactions (ADRs), have become a major public health concern and often cause drug development failure and withdrawal.

scholarly journals AAA proteins: in search of a common molecular basis

EMBO Reports ◽  
2001 ◽  
Vol 2 (11) ◽  
pp. 980-985 ◽  
Author(s):  
Michael R Maurizi ◽  
Chou‐Chi H Li
Keyword(s):  
Molecular Basis ◽  
Common Molecular Basis

scholarly journals Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

2020 ◽  
Vol 1 ◽  
Author(s):  
Maria João Gouveia ◽  
Maria Y. Pakharukova ◽  
Gabriel Rinaldi ◽  
Viatcheslav A. Mordvinov ◽  
Paul J. Brindley ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Molecular Basis ◽  
Liver Fluke ◽  
Helminth Infection ◽  
Fasciola Hepatica ◽  
Dna Bases ◽  
Liquid Chromatography Mass Spectrometry ◽  
Food Borne ◽  
Liver Flukes ◽  
Compare And Contrast

AbstractEarlier reports revealed oxysterol metabolites of Opisthorchis spp. liver fluke origin conjugated with DNA bases, suggesting that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of the infection with these food-borne pathogens. Here, we employed liquid chromatography-mass spectrometry to investigate, compare and contrast spectrograms of soluble extracts from Fasciola hepatica adult worms from bile ducts of cattle with those from O. viverrini and O.felineus from experimentally infected hamsters. F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. These findings support the postulate that parasitic oxysterol-like metabolites could be related to carcinogenesis associated to infection and they point to a molecular basis for the differences among major groups of liver flukes concerning infection-induced malignancy.

Spinal dysraphism, club feet, and dextrocardia with situs inversus totalis in a neonate: a rare association and review

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Surasak Puvabanditsin ◽  
Akreeti Maskey ◽  
Rannan Kased ◽  
Sadia Haleem ◽  
Rajeev Mehta
Keyword(s):  
Situs Inversus ◽  
Molecular Basis ◽  
Spinal Dysraphism ◽  
Situs Inversus Totalis ◽  
Chromosome 6 ◽  
Case Presentation ◽  
Snp Microarray ◽  
Rare Association ◽  
Common Molecular Basis ◽  
Field Defects

AbstractObjectivesThe spinal dysraphism and situs inversus are a rare association. Since 1909, reports on the coincidence of malformations of the spine and gastrointestinal tract have been published. So far there is no plausible explanation for the association.Case presentationWe report a term female infant with spinal dysraphism with club feet associated with dextrocardia and situs inversus totalis. Whole genome SNP microarray analysis was normal. However, there are extended contiguous regions of allele homozygosity [>8 Mb[megabase]) observed in chromosome 6 and 14.ConclusionsWe report a rare association of spinal dysraphism and situs inversus totalis in a neonate. We review the literature. There have recently been theorized by some to in fact represent nothing more than the presence of two or more polytopic field defects, with all the anomalies present sharing a common molecular basis.

scholarly journals Common molecular basis of the sentence comprehension network revealed by neurotransmitter receptor fingerprints

Cortex ◽  
2015 ◽  
Vol 63 ◽  
pp. 79-89 ◽  
Author(s):  
Karl Zilles ◽  
Maraike Bacha-Trams ◽  
Nicola Palomero-Gallagher ◽  
Katrin Amunts ◽  
Angela D. Friederici
Keyword(s):  
Molecular Basis ◽  
Sentence Comprehension ◽  
Neurotransmitter Receptor ◽  
Common Molecular Basis

A common molecular basis for membrane docking and functional priming of synaptic vesicles

2009 ◽  
Vol 30 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Léa Siksou ◽  
Frédérique Varoqueaux ◽  
Olivier Pascual ◽  
Antoine Triller ◽  
Nils Brose ◽  
...  
Keyword(s):  
Synaptic Vesicles ◽  
Molecular Basis ◽  
Common Molecular Basis
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