Inhibition of γ-irradiation induced adhesion molecules and NO production by alginate in human endothelial cells

2001 ◽  
Vol 24 (5) ◽  
pp. 466-471 ◽  
Author(s):  
Eun-Wha Son ◽  
Chul-Koo Cho ◽  
Dong-Kwon Rhee ◽  
Suhkneung Pyo
Keyword(s):  
Endothelial Cells ◽  
Adhesion Molecules ◽  
No Production ◽  
Human Endothelial Cells ◽  
Γ Irradiation

1P-0187 Effect of humancytomegalovirus and glucose on adhesion molecules expression in cultured human endothelial cells

2003 ◽  
Vol 4 (2) ◽  
pp. 61
Author(s):  
T. Altannvch ◽  
K. Roubalova ◽  
P. Kucera ◽  
M. Andel ◽  
U. Tsetsegmaa
Keyword(s):  
Endothelial Cells ◽  
Adhesion Molecules ◽  
Human Endothelial Cells

scholarly journals Differential Signal Transduction of Progesterone and Medroxyprogesterone Acetate in Human Endothelial Cells

Endocrinology ◽  
2004 ◽  
Vol 145 (12) ◽  
pp. 5745-5756 ◽  
Author(s):  
Tommaso Simoncini ◽  
Paolo Mannella ◽  
Letizia Fornari ◽  
Antonella Caruso ◽  
Monica Y. Willis ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Signal Transduction ◽  
Endothelial Cells ◽  
Glucocorticoid Receptor ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Medroxyprogesterone Acetate ◽  
Intercellular Adhesion Molecule ◽  
Human Endothelial Cells ◽  
Intercellular Adhesion Molecule 1

Abstract The conjugated equine estrogens-only arm of the Women’s Health Initiative trial, showing a trend toward protection from heart disease as opposed to women receiving also medroxyprogesterone acetate (MPA), strengthens the debate on the cardiovascular effects of progestins. We compared the effects of progesterone (P) or MPA on the synthesis of nitric oxide and on the expression of leukocyte adhesion molecules, characterizing the signaling events recruited by these compounds. Although P significantly increases nitric oxide synthesis via transcriptional and nontranscriptional mechanisms, MPA is devoid of such effects. Moreover, when used together with physiological estradiol (E2) concentrations, P potentiates E2 effects, whereas MPA impairs E2 signaling. These findings are observed both in isolated human endothelial cells as well as in vivo, in ovariectomized rat aortas. A marked difference in the recruitment of MAPK and phosphatidylinositol-3 kinase explains the divergent effects of the two gestagens. In addition, both P and MPA decrease the adhesiveness of endothelial cells for leukocytes when given alone or with estrogen. MPA is more potent than P in inhibiting the expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1. However, when administered together with physiological amounts of glucocorticoids, MPA (which also binds glucocorticoid receptor) markedly interferes with the hydrocortisone-dependent stabilization of the transcription factor nuclear factor κB and with the expression of adhesion molecules, acting as a partial glucocorticoid receptor antagonist. Our findings show significant differences in the signal transduction pathways recruited by P and MPA in endothelial cells, which may have relevant clinical implications.

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