Expression of p53 protein in cancers of small intestine and its relationship to clinical course and prognosis

1997 ◽  
Vol 9 (1) ◽  
pp. 49-52
Author(s):  
Chunlin Ge ◽  
Sanguang He ◽  
Yulin Tian ◽  
Hengchun Qu ◽  
Anguang He
Keyword(s):  
Small Intestine ◽  
Clinical Course ◽  
P53 Protein

scholarly journals Primary Adenosquamous Cell Carcinoma of the Ileum in a Dog

2020 ◽  
Vol 7 (4) ◽  
pp. 155
Author(s):  
Masashi Yuki ◽  
Roka Shimada ◽  
Tetsuo Omachi
Keyword(s):  
Small Intestine ◽  
Case Report ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Clinical Course ◽  
Mass Lesion ◽  
Abdominal Radiography ◽  
First Case ◽  
History Of

A 9-year-old male, castrated Chihuahua was examined because of a 7-day history of intermittent vomiting. A mass in the small intestine was identified on abdominal radiography and ultrasonography. Laparotomy revealed a mass lesion originating in the ileum, and surgical resection was performed. The mass was histologically diagnosed as adenosquamous cell carcinoma. Chemotherapy with carboplatin was initiated, but the dog was suspected to have experienced recurrence 13 months after surgery and died 3 months later. To our knowledge, this is the first case report to describe the clinical course of adenosquamous cell carcinoma in the small intestine of a dog.

Overexpression of p53 protein and point mutation of K-ras genes in primary carcinoma of the small intestine

2002 ◽  
Author(s):  
Ken-ichi Nishiyama ◽  
Takashi Yao ◽  
Hirotoshi Yonemasu ◽  
Koji Yamaguchi ◽  
Masao Tanaka ◽  
...  
Keyword(s):  
Small Intestine ◽  
Point Mutation ◽  
P53 Protein ◽  
Primary Carcinoma ◽  
Ras Genes

scholarly journals Ileal neuroendocrine tumor: diagnosis by endoscopic capsule

2021 ◽  
Vol 46 (1) ◽  
pp. 34-37
Author(s):  
Vitorino Modesto Dos Santos ◽  
Matheus Dantas Gomes Gonçalves ◽  
Vinicius Grigolli ◽  
Nataliê Almeida Silva ◽  
Lister Arruda Modesto dos Santos ◽  
...  
Keyword(s):  
Small Intestine ◽  
Neuroendocrine Tumor ◽  
Capsule Endoscopy ◽  
Chromogranin A ◽  
Open Surgery ◽  
Clinical Course ◽  
Neuron Specific Enolase ◽  
Distant Metastases ◽  
Imaging Studies ◽  
Endoscopic Capsule

The diagnosis of neuroendocrine tumors of the small intestine is usually challenging. They are infrequent, and the clinical course is insidious with nonspecific manifestations. Routine endoscopic and abdominal imaging studies are more often unremarkable. Therefore, distant metastases are frequently detected at the time of diagnosis. The tumor markers chromogranin A, synaptophysin, and neuron-specific enolase, and capsule endoscopy, and device-assisted enteroscopy are useful resources to establish a diagnosis. The aim was to present a case of neuroendocrine tumor of small intestine diagnosed with base in findings of the capsule endoscopy and further open surgery.

scholarly journals Clinical Coccidiosis in a Boar Stud

2003 ◽  
Vol 15 (4) ◽  
pp. 387-389 ◽  
Author(s):  
Michael J. Yaeger ◽  
Andrew Holtcamp ◽  
Julie A. Jarvinen
Keyword(s):  
Small Intestine ◽  
Antibiotic Therapy ◽  
Laboratory Tests ◽  
Clinical Course ◽  
Clinical Signs ◽  
State University ◽  
Iowa State University ◽  
Diagnostic Laboratory ◽  
Fecal Samples ◽  
History Of

This report describes an outbreak of coccidiosis in a boar stud. A live, untreated, adult boar with a history of diarrhea was submitted to the Iowa State University Veterinary Diagnostic Laboratory, Ames, IA. For a 3-month period, approximately 40% of the boars in this stud had developed gray to brown diarrhea that lasted 1–3 days. Affected boars did not lose condition, and antibiotic therapy did not appear to affect the clinical course of the disease. At necropsy, the distal ileum was palpably thickened and covered by a thick, yellow-green, fibrinous exudate. Microscopic changes in the ileum consisted of an erosive enteritis associated with the presence of numerous coccidia within mid to superficial villus enterocytes. The mucosa was covered by a fibrinous exudate admixed with numerous nonsporulated coccidian oocysts. A light growth of Salmonella enterica serovar Derby was isolated from the small intestine of this animal, but laboratory tests were negative for Lawsonia and Brachyspira spp. Individual or paired fecal samples were obtained from 6 additional boars experiencing similar clinical signs. Numerous Eimeria spinosa oocysts were identified in these samples. Neither Salmonella nor Brachyspira spp. were cultured from submitted fecal samples. Necropsy of a live boar and examination of feces from 6 additional animals confirmed that the mild, sporadic, transient diarrhea in this boar stud was due to coccidiosis.

scholarly journals STUDY OF ELECTROLYTE DISORDERS AS CRITERION-IMPORTANT MARKERS OF ENDOGENOUS INTOXICATION IN PATIENTS WITH ANASTOMOSIS LEAKEGE AGAINST A BACKGROUND OF RESECTION OF THE SMALL INTESTINE

2020 ◽  
pp. 176-181
Author(s):  
M. Ye. Tymchenko
Keyword(s):  
Small Intestine ◽  
Small Bowel ◽  
Iron Content ◽  
Serum Iron ◽  
Clinical Course ◽  
Bowel Anastomosis ◽  
Second Stage ◽  
Iron Saturation ◽  
Endogenous Intoxication ◽  
Objective Indicators

Summary. The aim of the study was to study the dependence of ion exchange and saturation with iron transferrin on the background of increasing endotoxicosis, depending on the severity of the clinical course of acute small bowel obstruction and peritonitis. Materials and methods. The research was carried out at the SI «ZIGUS NAMSU» and was based on the analysis of laboratory data of 63 patients with a failure of small intestinal anastomoses who in the future needed one of the options of resections of the segments of the small intestine, which were treated in the clinic from 2016 to 2019. All patients were divided into 3 groups according to the degree of physical severity of the condition on the APACHE II scale. The study was conducted in two stages: the first stage examined the content of zinc, copper and iron ions in the serum of all patients studied, the second stage of the study in patients evaluated the objective indicators of endogenous intoxication on the basis of leukocyte index of intoxication, index of content molecular weight, malonic aldehyde and diene conjugates in serum and iron levels in whole blood, as well as its serum. Results and Discussion. The study of Fe2+, Zn2+, Cu2+ metabolism in the serum of all patients with inflammatory phenomena of the peritoneum on the background of anastomosis failure revealed significant changes. In the clinical group of patients with small bowel anastomosis, the level of zinc upon admission to the hospital was significantly increased. In the second stage, we conducted a study on the detection of an increase in serum iron content, endogenous intoxication and a decrease in transferrin iron saturation depending on the clinical course of the disease in patients with acute intestinal obstruction and peritonitis and the degree of contamination of the small intestine. The results shown in study indicate that in the studied patients, depending on the severity of the disease there is a progressive decrease in the content of iron in whole blood, along with an increase in its serum level against the background of a significant decrease in iron saturation and increase in objective indicators of endogenous intoxication. Conclusions. On the basis of the results of the research, we can conclude that the increase of serum iron content with simultaneous decrease of transferrin iron saturation in the studied patients on the background of intensification of endotoxicosis depending on the severity of the condition, considering it as a factor of increasing the aggressiveness of bacterial resistance and flora correlates with the severity of the clinical course, according to which appropriate adequate additional corrective therapy is performed in complex surgery. treatment of patients with a small bowel anastomosis.

scholarly journals A Case of Tuberculosis of the Small Intestine Associated with a Characteristic Clinical Course.

2001 ◽  
Vol 62 (5) ◽  
pp. 1188-1192
Author(s):  
Katsunori TAKEUCHI ◽  
Koyo KIHARA ◽  
Ikuo NAGAMORI ◽  
Yoshimichi UEDA ◽  
Junichi MATSUBARA
Keyword(s):  
Small Intestine ◽  
Clinical Course

scholarly journals Spontaneous Free Perforation of the Small Intestine in Crohn’s Disease

2002 ◽  
Vol 16 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Hugh J Freeman
Keyword(s):  
Small Intestine ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Course ◽  
Intestinal Disease ◽  
Clinical Feature ◽  
Free Perforation ◽  
Female Patients ◽  
Immunosuppressive Medications ◽  
Male Patients

Spontaneous free perforation of the small intestine is a rare but often dramatic event in the clinical course of Crohn’s disease. Fifteen new cases of spontaneous free perforation of the small intestine - nine female patients and six male patients – were discovered in a series of 1000 consecutively evaluated patients with Crohn’s disease seen during a period spanning 20 years, for an estimated frequency of 1.5%. Spontaneous free perforation was the presenting clinical feature of Crohn’s disease in nine (60%) of the newly discovered cases. Most perforations were located in the ileum rather than in the jejunum, and there were no duodenal free perforations. One patient with extensive intestinal disease presented with concomitant free perforations of the jejunum and ileum, while a second patient had two free ileal perforations that developed independently, separated by about six years. No perforations were the result of a superimposed malignant process, ie, adenocarcinoma or lymphoma. There have been no mortalities, and the subsequent clinical course of these patients has been limited to a minority requiring corticosteroid or immunosuppressive medications, or further surgical resections.

Electron probe x-ray microanalysis and electron microscopy of amino acid absorption and transport by the small intestine: inhibition by chemical poisons and correlation to the elemental composition of the epithelial cells

1986 ◽  
Vol 44 ◽  
pp. 134-135
Author(s):  
A. J. Tousimis
Keyword(s):  
Small Intestine ◽  
Amino Acid ◽  
Epithelial Cells ◽  
Elemental Composition ◽  
Isotope Labeling ◽  
Structural Components ◽  
X Ray ◽  
Human Small Intestine ◽  
Transport Studies

The elemental composition of amino acids is similar to that of the major structural components of the epithelial cells of the small intestine and other tissues. Therefore, their subcellular localization and concentration measurements are not possible by x-ray microanalysis. Radioactive isotope labeling: I131-tyrosine, Se75-methionine and S35-methionine have been successfully employed in numerous absorption and transport studies. The latter two have been utilized both in vitro and vivo, with similar results in the hamster and human small intestine. Non-radioactive Selenomethionine, since its absorption/transport behavior is assumed to be the same as that of Se75- methionine and S75-methionine could serve as a compound tracer for this amino acid.

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