Preparation andIn vitro release characteristics of hydrophilic albumin microspheres containing methotrexate and methotrexate-human serum albumin conjugates

1992 ◽  
Vol 15 (2) ◽  
pp. 162-168 ◽  
Author(s):  
Sung-Joo Hwang ◽  
Myung Gull Lee ◽  
Chong-Kook Kim
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Albumin Microspheres ◽  
Vitro Release ◽  
Hydrophilic Albumin Microspheres

Comparison of the stability of Y-90-, Lu-177- and Ga-68- labeled human serum albumin microspheres (DOTA-HSAM)

2010 ◽  
Vol 37 (8) ◽  
pp. 861-867 ◽  
Author(s):  
Gerd Wunderlich ◽  
Eik Schiller ◽  
Ralf Bergmann ◽  
Hans-Jürgen Pietzsch
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Albumin Microspheres ◽  
The Stability

Human SeruM Albumin Microspheres Approximate Initial Organ-Specific Biodistributions of Transplanted Hepatocytes and Are Effective Cell Surrogates for Safety Studies

1998 ◽  
Vol 7 (3) ◽  
pp. 275-283 ◽  
Author(s):  
Pankaj Rajvanshi ◽  
Kuldeep K. Bhargava ◽  
Menes Afriyie ◽  
Maria V. Camaya ◽  
S. Gagandeep ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Femoral Vein ◽  
Rat Hepatocytes ◽  
Hepatocyte Transplantation ◽  
Albumin Microspheres ◽  
Liver Repopulation ◽  
Organ Specific ◽  
Safety Studies

Liver repopulation with transplanted hepatocytes will generate novel cell-based therapies, although translocation of transplanted cells into lungs through portasystemic shunts has the potential for embolic complications. To facilitate safety analysis of hepatocyte transplantation, we wished to obtain effective cell surrogates and analyzed biodistributions of similarly sized 99mTc-labeled human serum albumin microspheres and rat hepatocytes. Image analysis with dual 99mTc and 111In labels indicated that cells and microspheres were similarly distributed in the liver when injected into normal rats via the spleen. Also, their distributions were similar when injected via a femoral vein or the superior mesenteric vein with cells and microspheres localizing in lungs or liver, respectively. Upon intraportal injection in rats with portal hypertension, microspheres localized in both liver and lungs, consistent with portasystemic shunting. These data demonstrate that human serum albumin microspheres are effective cell surrogates for approximating the safety of hepatocyte transplantation and should be clinically useful.

Simple, fast preparation of gallium-68-labelled human serum albumin microspheres

1979 ◽  
Vol 4 (2) ◽  
pp. 95-99 ◽  
Author(s):  
J. P. Yvert ◽  
B. Mazi�re ◽  
M. Verhas ◽  
D. Comar
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Albumin Microspheres ◽  
Gallium 68

Originalarbeiten: Human Serum Albumin Microspheres for Lung Imaging – Preparation and Evaluation

1978 ◽  
Vol 14 (2) ◽  
pp. 57-61 ◽  
Author(s):  
Aleyamma Raju ◽  
R. Mani ◽  
K. D. Divekar ◽  
D. V. S. Narasimhan ◽  
A. D. Rahalkar ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Lung Imaging ◽  
Albumin Microspheres ◽  
Preparation And Evaluation
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