Reduction of proteinuria with captopril therapy in patients with focal segmental glomerulosclerosis and IgA nephropathy

1991 ◽  
Vol 160 (10) ◽  
pp. 319-321 ◽  
Author(s):  
A. P. Huissoon ◽  
S. Meehan ◽  
J. A. B. Keogh
Keyword(s):  
Iga Nephropathy ◽  
Focal Segmental Glomerulosclerosis ◽  
Segmental Glomerulosclerosis

scholarly journals Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. I. Immunohistochemical studies

2011 ◽  
Vol 79 (6) ◽  
pp. 635-642 ◽  
Author(s):  
Gary S. Hill ◽  
Khalil El Karoui ◽  
Alexandre Karras ◽  
Chantal Mandet ◽  
Jean-Paul Duong Van Huyen ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Focal Segmental Glomerulosclerosis ◽  
Segmental Glomerulosclerosis ◽  
Immunohistochemical Studies

scholarly journals Chronic kidney disease: a review of proteomic and metabolomic approaches to membranous glomerulonephritis, focal segmental glomerulosclerosis, and IgA nephropathy biomarkers

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Amir Taherkhani ◽  
Reyhaneh Farrokhi Yekta ◽  
Maede Mohseni ◽  
Massoud Saidijam ◽  
Afsaneh Arefi Oskouie
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Iga Nephropathy ◽  
Focal Segmental Glomerulosclerosis ◽  
Membranous Glomerulonephritis ◽  
Renal Diseases ◽  
Segmental Glomerulosclerosis ◽  
Therapeutic Procedures ◽  
Definition Of ◽  
End Stage

AbstractChronic Kidney Disease (CKD) is a global health problem annually affecting millions of people around the world. It is a comprehensive syndrome, and various factors may contribute to its occurrence. In this study, it was attempted to provide an accurate definition of chronic kidney disease; followed by focusing and discussing on molecular pathogenesis, novel diagnosis approaches based on biomarkers, recent effective antigens and new therapeutic procedures related to high-risk chronic kidney disease such as membranous glomerulonephritis, focal segmental glomerulosclerosis, and IgA nephropathy, which may lead to end-stage renal diseases. Additionally, a considerable number of metabolites and proteins that have previously been discovered and recommended as potential biomarkers of various CKDs using ‘-omics-’ technologies, proteomics, and metabolomics were reviewed.

Renal expression of intercellular adhesion molecule-1 in different forms of glomerulonephritis

1991 ◽  
Vol 81 (s25) ◽  
pp. 477-481 ◽  
Author(s):  
K. Lhotta ◽  
H. P. Neumayer ◽  
M. Joannidis ◽  
D. Geissler ◽  
P. KöNig
Keyword(s):  
Iga Nephropathy ◽  
Focal Segmental Glomerulosclerosis ◽  
Adhesion Molecule ◽  
Membranoproliferative Glomerulonephritis ◽  
Rapidly Progressive Glomerulonephritis ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Segmental Glomerulosclerosis ◽  
Mesangioproliferative Glomerulonephritis

1. Expression of intercellular adhesion molecule-1 was investigated in five normal kidneys and 47 renal biopsies with the use of monoclonal antibody 7F7 and immunoperoxidase staining. 2. In the normal kidney, intercellular adhesion molecule-1 was expressed on endothelial cells of glomerular and peritubular capillaries, on Bowman's capsule, on some interstitial cells and weakly in the mesangium. 3. Increased glomerular staining was detected in early cases of rapidly progressing glomerulonephritis (5/8) and in some cases of non-IgA mesangioproliferative glomerulonephritis (5/9), IgA nephropathy (3/5), Henoch-Schoenlein purpura (2/2), lupus nephritis (5/6) and focal segmental glomerulosclerosis (1/3). A decrease in intercellular adhesion molecule-1 expression was noted in advanced rapidly progressive glomerulonephritis (3/8), two cases of membraneous nephropathy, one severe mesangioproliferative glomerulonephritis biopsy, the two membranoproliferative glomerulonephritis biopsies and in sclerotic loops in focal segmental glomerulosclerosis. 4. Expression de novo on tubular epithelial cells occurred in rapidly progressive glomerulonephritis, in membranoproliferative glomerulonephritis, and to a lesser extent in some cases of membranous nephropathy, minimal change disease, IgA nephropathy, focal segmental glomerulosclerosis, a severe case of mesangioproliferative glomerulonephritis and in the mixed essential cryoglobulinaemia case. In 63% of positive tubuli, intraluminal cells which expressed CD18, the common β-chain of leucocyte-function-associated antigen-1, Mac-1 and p150,95, were present. 5. Intercellular adhesion molecule-1 was also found on the majority (59%) of infiltrating mononuclear cells in all forms of glomerulonephritis.

scholarly journals Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies

2011 ◽  
Vol 79 (6) ◽  
pp. 643-654 ◽  
Author(s):  
Khalil El Karoui ◽  
Gary S. Hill ◽  
Alexandre Karras ◽  
Luc Moulonguet ◽  
Valérie Caudwell ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Focal Segmental Glomerulosclerosis ◽  
Clinical Studies ◽  
Segmental Glomerulosclerosis
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