Variations in time of serum pancreatic enzyme levels in chronic pancreatitis and clinical course of the disease

1991 ◽  
Vol 8 (4) ◽  
Author(s):  
Luigi Benini ◽  
Silvio Caliari ◽  
Bruna Vaona ◽  
Giorgio Brocco ◽  
Rocco Micciolo ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Clinical Course ◽  
Pancreatic Enzyme

Carnitine profile in pancreatic enzyme supplemented patients with chronic pancreatitis

2007 ◽  
Vol 45 (05) ◽  
Author(s):  
M Figler ◽  
CG Talián ◽  
J Bene ◽  
J Cseh ◽  
I Battyány ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Enzyme

scholarly journals The clinical course of chronic pancreatitis associated with lipid disturbances in children

2012 ◽  
Vol 5 ◽  
pp. 286-290
Author(s):  
Grzegorz Oracz ◽  
Jarosław Kierkuś ◽  
Jerzy Socha ◽  
Józef Ryżko
Keyword(s):  
Chronic Pancreatitis ◽  
Clinical Course

Chronic pancreatitis

2020 ◽  
pp. 3218-3227
Author(s):  
Marco J. Bruno ◽  
Djuna L. Cahen
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Pancreatitis ◽  
Pancreatic Enzyme ◽  
Exocrine Insufficiency ◽  
Endocrine Insufficiency ◽  
Diabetes Mellitus Diagnosis ◽  
Permanent Loss ◽  
Stimulation Tests ◽  
Enteric Coated ◽  
Pancreatic Duct Stricture

Chronic pancreatitis is a major source of morbidity, loss in quality of life, and healthcare expenditure. It is most commonly caused by chronic alcoholism in adults and cystic fibrosis in children, but there are many other causes. Patients typically present with severe abdominal pain, but this may vary and even be absent. Exo- and endocrine insufficiency usually occur late in the disease course and reflect permanent loss of pancreatic parenchyma due to ongoing inflammation and fibrosis, exocrine insufficiency manifesting as steatorrhea and weight loss due to fat maldigestion and endocrine insufficiency as diabetes mellitus. Diagnosis is confirmed by imaging investigations such as CT, MRI, and endoscopic ultrasonography. Endoscopic retrograde cholangiopancreatography to diagnose chronic pancreatitis is obsolete. Hormone stimulation tests (e.g. secretin–cholecystokinin stimulation test) to diagnose exocrine insufficiency are largely abandoned because of their complexity and burden to patients. They are replaced by faecal elastase testing, even though this test is less sensitive. Management focuses on the treatment of pain using a stepwise approach. Initially, nonopioid analgesics are prescribed. Next, when feasible, endoscopic therapy is initiated, including pancreatic stone fragmentation by extracorporeal shock-wave lithotripsy, endotherapy to remove stone fragments, and placement of plastic stents to dilate any concomitant pancreatic duct stricture. If that fails or when, for example, the pancreatic head is enlarged, surgical intervention is indicated. Medical management includes enteric-coated pancreatic enzyme preparations and treatment of diabetes mellitus, usually by means of insulin. Abstinence from alcohol and smoking cessation are important predictors of disease and treatment outcome.

Pancreatic disease

2011 ◽  
pp. 611-618
Keyword(s):  
Pancreatic Cancer ◽  
Acute Pancreatitis ◽  
Chronic Pancreatitis ◽  
Enzyme Replacement Therapy ◽  
Replacement Therapy ◽  
Pancreatic Enzyme ◽  
Pancreatic Disease ◽  
Enzyme Replacement ◽  
Pancreatic Enzyme Replacement Therapy ◽  
Pancreatic Disorders

Pancreatic disorders 612 Pancreatic enzyme replacement therapy 616 See Table 27.1. The major pancreatic disorders include pancreatitis and pancreatic cancer. Pancreatitis results from the auto-digestion of the pancreas by activated pancreatic enzymes. It can be categorized as: • Chronic pancreatitis (CP). • Acute pancreatitis: •...

Etiology and Morphology Impact on the Clinical Course of Chronic Pancreatitis

Digestion ◽  
2020 ◽  
pp. 1-7
Author(s):  
Lukas Perkhofer ◽  
Theresa Besold ◽  
Julian Schmidberger ◽  
Thomas Seufferlein ◽  
Alexander Hann ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Clinical Course

scholarly journals A Case of Chronic Pancreatic Insufficiency Due to Valproic Acid in a Child

2001 ◽  
Vol 15 (2) ◽  
pp. 127-130 ◽  
Author(s):  
Mary Anne Cooper ◽  
Aubrey Groll
Keyword(s):  
Valproic Acid ◽  
Weight Loss ◽  
Acute Pancreatitis ◽  
Abdominal Pain ◽  
Chronic Pancreatitis ◽  
Pancreatic Insufficiency ◽  
Pancreatic Enzyme ◽  
Exocrine Pancreatic Insufficiency ◽  
Radiological Evaluation ◽  
Enzyme Replacement

A 14-year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis. The association with valproic acid was not recognized, and the child continued to take the drug. The patient eventually developed steatorrhea and weight loss that improved with pancreatic enzyme replacement. Radiological evaluation showed an atrophic pancreas. Without evidence of other etiological factors, valproic acid by itself appeared to be the cause of chronic pancreatitis with exocrine pancreatic insufficiency in this patient.

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