Palate development: Mechanisms and malformations

1987 ◽  
Vol 156 (11) ◽  
pp. 309-315 ◽  
Author(s):  
M. W. J. Ferguson
Keyword(s):  
Palate Development

Mesenchymal Smad4 mediated signaling is essential for palate development

2010 ◽  
Vol 36 (6) ◽  
pp. 460 ◽  
Author(s):  
Chi-Young Yoon ◽  
Jin-A Baek ◽  
Eui-Sic Cho ◽  
Seung-O Ko
Keyword(s):  
Palate Development

Morphological and molecular changes associated with Pitchfork during mouse palate development

2014 ◽  
Vol 358 (2) ◽  
pp. 385-393 ◽  
Author(s):  
Chengri Jin ◽  
Jong-Min Lee ◽  
Qinghuang Tang ◽  
Liwen Li ◽  
Min-Jung Lee ◽  
...  
Keyword(s):  
Molecular Changes ◽  
Palate Development

scholarly journals Onset of the acquired potentiality for fusion in the palatal shelves of rats

Development ◽  
1966 ◽  
Vol 16 (1) ◽  
pp. 171-182
Author(s):  
M. Pourtois
Keyword(s):  
Oral Cavity ◽  
Cleft Palate ◽  
Horizontal Plane ◽  
Horizontal Position ◽  
Palate Development

This paper is concerned with that phase of palate development in rats leading to fusion of the shelves in the midline. Previous experimentation in palate development in mammals has encompassed both the earlier phase of assumption of the horizontal position of the palatal shelves, and the subsequent approximation and fusion of the shelves. Since the two processes do not occur simultaneously and can theoretically be studied separately, it was possible and feasible to confine the experiment to the later fusion phase. The present research was designed to eliminate the possible confounding effects of palate rotation in vitro on the fusion of the shelves by approximation of the explanted palatal shelves in the same horizontal plane, irrespective of their original positions in the oral cavity. Current theories of cleft palate pathogenesis hold that either the palatal shelves fail to assume (rotate to) the horizontal position, or, that having done so, they fail to fuse.

Palate Development: In Vitro Procedures

2003 ◽  
pp. 267-274
Author(s):  
M. Michele Pisano ◽  
Robert M. Greene
Keyword(s):  
Palate Development ◽  
Development In Vitro

A Novel Pathogenic Variant in the MN1 Gene in a Patient Presenting with Rhombencephalosynapsis and Craniofacial Anomalies, Expanding MN1 C-terminal Truncation Syndrome

2021 ◽  
Author(s):  
Carmen Palma ◽  
Pérez Mohand Patricia ◽  
José M. Lezana ◽  
Jaime Cruz ◽  
Juan F. Quesada ◽  
...  
Keyword(s):  
De Novo ◽  
Pathogenic Variant ◽  
Craniofacial Anomalies ◽  
Osteoblast Proliferation ◽  
Terminal Portion ◽  
Transcription Activator ◽  
Palate Development ◽  
Partial Rhombencephalosynapsis ◽  
And Function ◽  
Craniofacial Defects

AbstractMeningioma-1 is a transcription activator that regulates mammalian palate development and is required for appropriate osteoblast proliferation, motility, differentiation, and function. Microdeletions involving the MN1 gene have been linked to syndromes including craniofacial anomalies, such as Toriello–Carey syndrome. Recently, truncating variants in the C-terminal portion of the MN1 transcriptional factor have been linked to a characteristic and distinct phenotype presenting with craniofacial anomalies and partial rhombencephalosynapsis, a rare brain malformation characterized by midline fusion of the cerebellar hemispheres with partial or complete loss of the cerebellar vermis. It has been called MN1 C-terminal truncation (MCTT) syndrome or CEBALID (Craniofacial defects, dysmorphic Ears, Brain Abnormalities, Language delay, and Intellectual Disability) and suggested to be caused by dominantly acting truncated protein MN1 instead of haploinsufficiency. As a proto-oncogene, MN1 is also involved in familial meningioma. In this study, we present a novel case of MCTT syndrome in a female patient presenting with craniofacial anomalies and rhombencephalosynapsis, harboring a de novo pathogenic variant in the MN1 gene: c.3686_3698del, p.(Met1229Argfs*87).

A new in vitro system for studying secondary palate development

Development ◽  
1975 ◽  
Vol 34 (2) ◽  
pp. 485-495
Author(s):  
L. Brinkley ◽  
G. Basehoar ◽  
A. Branch ◽  
J. Avery
Keyword(s):  
Gas Permeation ◽  
Present System ◽  
Embryonic Mouse ◽  
Fluid Medium ◽  
In Vitro System ◽  
Palate Development ◽  
Fixed Orientation ◽  
The Brain

An in vitro system was devised which supports palate development in partially dissected embryonic mouse heads. The heads were suspended in the culture chamber so that they were not held in a fixed orientation and were constantly surrounded with a fluid medium. Under these circumstances the developing palate must effect closure without the aid of gravitational forces. The culture medium was constantly circulated, gassed with 95% O2, 5% CO2 using hollow fiber gas permeation devices, and kept at 34°C. Swiss-Webster mouse embryos of 12 days 12–18 h (ca. 48 h prior to expected in vivo closure) or 13 days 8–14 h (ca. 24 h prior to closure) were used to test the ability of the system to support palatal development. Embryonic heads were dissected in one of two ways before culture: brain and tongue removed, or brain, tongue and mandible removed. After 24 h in culture, preparations of either age with only the brain and tongue removed had made substantially greater progress than their counterparts with the brain, tongue and mandible removed. With only the brain and tongue removed, the palatal shelves were contacting, adhered or fused in 67 % of the older embryos, whereas most of the embryos of the same age cultured with the brain, tongue and mandible removed had shelves that were not fully elevated and still separated by a moderate gap. Thus for maximal progress in the present system, the oral cavity must be intact except for the tongue.

Morphological study of cleft palate development in 5-fluorouracil-treated hamster fetuses

Development ◽  
1980 ◽  
Vol 57 (1) ◽  
pp. 119-128
Author(s):  
Ravindra M. Shah ◽  
David T. W. Wong
Keyword(s):  
Cleft Palate ◽  
Gestational Age ◽  
Horizontal Plane ◽  
Morphological Study ◽  
Fetal Weight ◽  
Rating System ◽  
Crown Rump Length ◽  
Palate Development ◽  
Palatal Development

Morphogenesis of palate was studied in normal and 5-fluorouracil-treated hamster fetuses. The results showed that normal palatal development was completed between days 12 and 13 of gestation. In 5-fluorouracil-assaulted palate the reorientation of shelves from a vertical to horizontal plane was delayed. Crown-rump length, gestational age and fetal weight were reliable predictors of the stages of normal palatal development, whereas the morphological rating system was not. Following 5-fiuorouracil treatment, however, crown-rump length, weight and morphological rating were poor indicators of the stage of palatal development.

Autoradiographic study of macromolecular synthesis in the fusion epithelium of the developing rat primary palate in vitro

Development ◽  
1979 ◽  
Vol 50 (1) ◽  
pp. 145-154
Author(s):  
Alvaro A. Figueroa ◽  
Robert M. Pratt
Keyword(s):  
Autoradiographic Study ◽  
Whole Embryo Culture ◽  
Glycoprotein Synthesis ◽  
Palate Development ◽  
Molecular Events ◽  
Secondary Palate ◽  
Primary Palate ◽  
Epithelial Fusion ◽  
Developing Rat

The facial processes involved in primary palate formation undergo epithelial fusion in a manner morphologically analogous to that observed during secondary palate formation. We have used whole embryo culture to analyze the synthesis of macromolecules (DNA, protein, glycoprotein) in the primary palate, based on the incorporation of various labeled precursors. The results of this study demonstrate that changes in the synthesis of macromolecules occur during the fusion of the facial processes, which resemble those previously reported to occur during secondary palate development. These changes include cessation of DNA synthesis in cells in a restricted zone of the epithelium, concomitant with maintenance of glycoprotein synthesis. These findings indicate that the molecular events underlying the development of the primary and secondary palate may be similar.

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