The susceptibility of laboratory animals to experimental infection with Brucella

1933 ◽  
Vol 8 (4) ◽  
pp. 150-163
Author(s):  
S. G. Rainsford
Keyword(s):  
Experimental Infection ◽  
Laboratory Animals

Susceptibility of laboratory animals to experimental infection with Ife virus

1990 ◽  
Vol 22 (1) ◽  
pp. 11-16 ◽  
Author(s):  
G.O. Ezeifeka ◽  
J.U. Umoh ◽  
C.D. Ezeokoli ◽  
N.E. Gomwalk
Keyword(s):  
Experimental Infection ◽  
Laboratory Animals

scholarly journals Experimental Infection of Laboratory Animals and Sheep with Gongylonema pulchrum in Japan

2003 ◽  
Vol 65 (8) ◽  
pp. 921-925 ◽  
Author(s):  
Noboru KUDO ◽  
Tooru KONEGUCHI ◽  
Hiromi IKADAI ◽  
Takashi OYAMADA
Keyword(s):  
Experimental Infection ◽  
Laboratory Animals ◽  
Gongylonema Pulchrum

scholarly journals Experimental infection of bovine leukemia virus in small laboratory animals.

1988 ◽  
Vol 50 (6) ◽  
pp. 1245-1251 ◽  
Author(s):  
Hiroshi SENTSUI ◽  
Yuji KONO ◽  
Shigeyoshi ITOHARA ◽  
Seishi ISHINO
Keyword(s):  
Experimental Infection ◽  
Bovine Leukemia Virus ◽  
Leukemia Virus ◽  
Laboratory Animals ◽  
Small Laboratory

scholarly journals Flow cytometry evaluation of the rhesus monkey cellular immunity following the Zaire ebolavirus (Filoviridae; Ebolavirus: Zaire ebolavirus) experimental infection

2021 ◽  
Vol 66 (4) ◽  
pp. 289-298
Author(s):  
G. V. Borisevich ◽  
S. L. Kirillova ◽  
I. V. Shatokhina ◽  
V. N. Lebedev ◽  
N. V. Shagarova ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
T Lymphocytes ◽  
Rhesus Monkey ◽  
Cellular Immunity ◽  
Experimental Infection ◽  
Rhesus Monkeys ◽  
Laboratory Animals ◽  
Double Positive ◽  
Zaire Ebolavirus ◽  
Lymphocyte Populations

Introduction. The outbreaks of the Zaire ebolavirus (ZE) disease (ZED) that have arisen in the last decade determine the need to study the infection pathogenesis, the formation of specific immunity forming as well as the development of effective preventive and therapeutic means. All stages of fight against the ZED spread require the experimental infection in sensitive laboratory animals, which are rhesus monkeys in case of this disease .The aim of the study is to evaluate the rhesus monkey cellular immunity following the ZE experimental infection by the means of flow cytometry (cytofluorimetry).Material and methods. Male rhesus monkeys were intramuscularly infected by the dose of 15 LD50 (dose of the pathogen that causes 50% mortality of infected animals) of the ZE, the Zaire strain (ZEBOV). Levels of 18 peripheral blood lymphocyte populations of the animals before the ZE experimental infection and at the terminal stage of the disease were assessed using flow cytometry.Results and discussion. The certain changes in the levels of the lymphocyte populations were observed following infection, indicating simultaneous activation and suppression of the immune system during ZED. The increase in content was observed for T-lymphocytes, T-helper and cytotoxic T-lymphocytes expressing the corresponding markers of early activation. The decrease was recorded for T-lymphocytes and double-positive T-lymphocytes expressing corresponding markers of late activation, as well as natural killer cells expressing CD8 (p < 0.05).Conclusion. For the first time in the Russian Federation, the rhesus monkey cellular immunity before and after the ZE experimental infection was assessed using flow cytometry.

The Domestic Fowl of Uganda as a Host for Trypanosomes of the Brucei Group

Parasitology ◽  
1933 ◽  
Vol 25 (2) ◽  
pp. 171-191 ◽  
Author(s):  
H. Lyndhurst Duke
Keyword(s):  
Experimental Infection ◽  
Domestic Fowl ◽  
Natural Infection ◽  
Laboratory Animals ◽  
Small Laboratory ◽  
Infected Blood

For many years it has been known that the domestic fowl, together with some other species of birds, is susceptible to experimental infection by trypanosomes of the brucei group. The successful experiments were performed in European laboratories with strains whose virulence had been greatly exalted as the result of long maintenance in small laboratory animals. Infection was induced by inoculation of infected blood into the comb, the peritoneum or a vein. A natural infection of birds with these trypanosomes has, as far as I know, never yet been reported.

scholarly journals Animal Models for Gammaherpesvirus Infections: Recent Development in the Analysis of Virus-Induced Pathogenesis

Pathogens ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 116 ◽  
Author(s):  
Shigeyoshi Fujiwara ◽  
Hiroyuki Nakamura
Keyword(s):  
Animal Models ◽  
Experimental Infection ◽  
Specific Treatment ◽  
Clinical Importance ◽  
Laboratory Animals ◽  
Human Immune System ◽  
Immunodeficient Mice ◽  
Barr Virus ◽  
Treatment And Prevention ◽  
Epstein Barr

Epstein–Barr virus (EBV) is involved in the pathogenesis of various lymphomas and carcinomas, whereas Kaposi’s sarcoma-associated herpesvirus (KSHV) participates in the pathogenesis of endothelial sarcoma and lymphomas. EBV and KSHV are responsible for 120,000 and 44,000 annual new cases of cancer, respectively. Despite this clinical importance, no chemotherapies or vaccines have been developed for virus-specific treatment and prevention of these viruses. Humans are the only natural host for both EBV and KSHV, and only a limited species of laboratory animals are susceptible to their experimental infection; this strict host tropism has hampered the development of their animal models and thereby impeded the study of therapeutic and prophylactic strategies. To overcome this difficulty, three main approaches have been used to develop animal models for human gammaherpesvirus infections. The first is experimental infection of laboratory animals with EBV or KSHV. New-world non-human primates (NHPs) and rabbits have been mainly used in this approach. The second is experimental infection of laboratory animals with their own inherent gammaherpesviruses. NHPs and mice have been mainly used here. The third, a recent trend, employs experimental infection of EBV or KSHV or both to immunodeficient mice reconstituted with human immune system components (humanized mice). This review will discuss how these three approaches have been used to reproduce human clinical conditions associated with gammaherpesviruses and to analyze the mechanisms of their pathogenesis.

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