Comparative study of chuanxiong and dextran 40 in the treatment of acute cerebral infarction

1995 ◽  
Vol 1 (1) ◽  
pp. 17-20
Author(s):  
Da-ren Chen ◽  
Yin-mian Shi ◽  
Gui-qin Tian ◽  
Jie Gong
Keyword(s):  
Cerebral Infarction ◽  
Comparative Study ◽  
Acute Cerebral Infarction ◽  
Dextran 40

scholarly journals Long-Term Safety and Efficacy of Antiplatelet Therapy in Patients With Cerebral Infarction With Thrombocytopenia

2021 ◽  
Vol 27 ◽  
pp. 107602962098006
Author(s):  
Shijie Guo ◽  
Yingying Lin ◽  
Xiaoye Ma ◽  
Yanxin Zhao ◽  
Aiping Jin ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Antiplatelet Therapy ◽  
Multivariate Regression Analysis ◽  
Acute Cerebral Infarction ◽  
Score Change ◽  
Recurrence Rates ◽  
Primary Endpoints ◽  
Hemorrhagic Events

This study aimed to investigate the long-term safety and benefits of antiplatelet therapy in patients with cerebral infarction with thrombocytopenia, as evidence regarding this was limited. This cohort trial assessed patients with acute cerebral infarction with thrombocytopenia treated in the Neurology Department of Shanghai Tenth People’s Hospital from January 2016 to December 2018, and enrolled patients were followed up for 9 months. The patients were divided into non-antiplatelet and antiplatelet groups based on the actual intake of antiplatelet drugs. Primary endpoints included hemorrhagic events, recurrence of cerebral infarction, and activity of daily living (ADL) score changes. To balance baseline clinical data, propensity score matching was applied, and there were finally 65 matched patients, including 30 and 35 in the antiplatelet and non-antiplatelet groups, respectively. There were no differences in hemorrhagic and cerebral infarction recurrence rates between the 2 groups. ADL score change was higher in the antiplatelet group than in the non-antiplatelet group (10 vs 5, p = 0.039). In multivariate regression analysis, antiplatelet therapy significantly predicted a positive change in ADL scores [B = 8.381, 95% confidence interval (0.56-16.19)]. In patients with acute cerebral infarction with thrombocytopenia, antiplatelet therapy could the improve the quality of life in the chronic stage.

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