Inhibition of the mitogen activated protein kinase ERK1/2 amplifies ochratoxin A toxicity in the proximal tubule of the kidney

2003 ◽  
Vol 19 (2) ◽  
pp. 118-123 ◽  
Author(s):  
C. Sauvant ◽  
H. Holzinger ◽  
M. Gekle
Keyword(s):  
Protein Kinase ◽  
Proximal Tubule ◽  
Ochratoxin A ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein

scholarly journals A Journey Through Mitogen-Activated Protein Kinase and Ochratoxin A Interactions

2009 ◽  
Vol 60 (4) ◽  
pp. 449-456 ◽  
Author(s):  
Lada Rumora ◽  
Tihana Grubišić
Keyword(s):  
Protein Kinase ◽  
Ochratoxin A ◽  
Mitogen Activated Protein Kinase ◽  
Balkan Endemic Nephropathy ◽  
Cytotoxic Action ◽  
Extracellular Signal ◽  
Increased Risk ◽  
Mitogen Activated Protein ◽  
Endemic Nephropathy ◽  
A Cell

A Journey Through Mitogen-Activated Protein Kinase and Ochratoxin A InteractionsOchratoxin A (OTA) is a ubiquitous mycotoxin with potential nephrotoxic, carcinogenic, and cytotoxic action. It has been proposed that OTA might be involved in the development of Balkan endemic nephropathy, which is associated with an increased risk of urinary tract tumours, and of other forms of interstitial nephritis. Cell susceptibility to OTA mainly depends on mycotoxin concentrations, duration of exposure, and intracellular molecular and genetic context. OTA can affect a cell by stimulating or inhibiting certain signalling pathways such as mitogen-activated protein kinase (MAPK). Three major mammalian MAPKs have been described: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK. All MAPKs regulate diverse cellular programmes, but in most cases ERKs have been linked to cell survival, while JNKs, and p38 MAPKs have been implicated in cell death by apoptosis. This review looks into OTA-mediated MAPK activation and its effects.

Age-Related Changes in Activation of Mitogen-Activated Protein Kinase Cascades by Oxidative Stress

1998 ◽  
Vol 3 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Kathryn Z Guyton ◽  
Myriani Gorospe ◽  
Xiantao Wang ◽  
Yolanda D Mock ◽  
Gertrude C Kokkonen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Age Related ◽  
Mitogen Activated Protein ◽  
Age Related Changes
Sign in / Sign up

Export Citation Format

Share Document