Pharmacology of morphine metabolites

Piotr K. Janicki

doi:10.1007/bf02938295

Detection, isolation and characterization of normorphine and norcodeine as morphine metabolites in man

Journal of Pharmacy and Pharmacology ◽

10.1111/j.2042-7158.1974.tb09303.x ◽

1974 ◽

Vol 26 (6) ◽

pp. 393-398 ◽

Cited By ~ 24

Author(s):

UDO BOERNER ◽

ROBERT L. ROE ◽

CHARLES E. BECKER

Keyword(s):

Isolation And Characterization ◽

Morphine Metabolites

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A Stereospecific Microassay for the Determination of Morphine-6-β-D-Glucuronide and other Active Morphine Metabolites in the Neonatal Guinea Pig

Journal of Liquid Chromatography ◽

10.1080/10826079308019591 ◽

1993 ◽

Vol 16 (12) ◽

pp. 2545-2561 ◽

Cited By ~ 14

Author(s):

Laine J. Murphey ◽

George D. Olsen

Keyword(s):

Guinea Pig ◽

Morphine Metabolites

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Morphine metabolites

Acta Anaesthesiologica Scandinavica ◽

10.1111/j.1399-6576.1997.tb04625.x ◽

1997 ◽

Vol 41 (1) ◽

pp. 116-122 ◽

Cited By ~ 165

Author(s):

L. L. CHRISTRUP

Keyword(s):

Morphine Metabolites

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Isolation and Identification of Morphine 3- and 6-Glucuronides, Morphine 3,6-Diglucuronide, Morphine 3-Ethereal Sulfate, Normorphine, and Normorphine 6-Glucuronide as Morphine Metabolites in Humans

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600660921 ◽

1977 ◽

Vol 66 (9) ◽

pp. 1288-1293 ◽

Cited By ~ 96

Author(s):

S.Y. Yeh ◽

C.W. Gorodetzky ◽

H.A. Krebs

Keyword(s):

Isolation And Identification ◽

Morphine Metabolites

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Concentrations of morphine and morphine metabolites in CSF and plasma during continuous subcutaneous morphine administration in cancer pain patients

Pain ◽

10.1016/s0304-3959(96)03102-8 ◽

1996 ◽

Vol 68 (2) ◽

pp. 209-216 ◽

Cited By ~ 33

Author(s):

Tomas Wolff ◽

Håkan Samuelsson ◽

Thomas Hedner

Keyword(s):

Cancer Pain ◽

Morphine Administration ◽

Pain Patients ◽

Morphine Metabolites

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Concentrations of morphine, morphine metabolites and peptides in human CSF and plasma

Pain ◽

10.1016/0304-3959(90)92512-o ◽

1990 ◽

Vol 41 ◽

pp. S188 ◽

Cited By ~ 8

Author(s):

R.F. Venn ◽

A. Michalkieaicz ◽

P. Hardy ◽

C. Wells

Keyword(s):

Morphine Metabolites

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Pain: morphine, metabolites, mambas, and mutations

The Lancet Neurology ◽

10.1016/s1474-4422(12)70287-9 ◽

2013 ◽

Vol 12 (1) ◽

pp. 18-20 ◽

Cited By ~ 9

Author(s):

Clifford J Woolf

Keyword(s):

Morphine Metabolites

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Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study

BMC Palliative Care ◽

10.1186/s12904-015-0052-9 ◽

2015 ◽

Vol 14 (1) ◽

Cited By ~ 7

Author(s):

Yong Joo Lee ◽

Sang-Yeon Suh ◽

Junghan Song ◽

Sanghee Shiny Lee ◽

Ah-Ram Seo ◽

...

Keyword(s):

Observational Study ◽

Advanced Cancer ◽

Intravenous Morphine ◽

Urine Concentrations ◽

Morphine Metabolites ◽

Serum And Urine

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Sensitive and Specific Morphine Radioimmunoassay with Iodine Label: Pharmacokinetics of Morphine in Man after Intravenous Administration

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456328402100415 ◽

1984 ◽

Vol 21 (4) ◽

pp. 318-325 ◽

Cited By ~ 30

Author(s):

R A Moore ◽

D Baldwin ◽

M C Allen ◽

P J Q Watson ◽

R E S Bullingham ◽

...

Keyword(s):

Intravenous Administration ◽

Drugs Of Abuse ◽

Cross Reactivity ◽

Pharmacokinetic Parameters ◽

Published Data ◽

Morphine Metabolites

Analysis of morphine in plasma by radioimmunoassay is complicated by interference from morphine metabolites, particularly morphine-3-glucuronide. This interference makes radioimmunoassay a poor technique to study the pharmacokinetics of morphine in man. The method described here is one which uses commercially available anti-morphine antiserum and separating reagent with a simply prepared iodinated morphine derivative. Cross-reactivity to morphine metabolites is negligible and the method correlates well with HPLC. Results obtained for pharmacokinetic parameters after intravenous administration in man are in agreement with published data using GLC or HPLC. The method is inexpensive, simple and rapid; choice of a different antiserum could allow the method to be used for screening for drugs of abuse such as morphine, diamorphine, codeine and dihydrocodeine.

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Potential analgesic contribution from morphine metabolites following intra-thecal morphine

Journal of Cardiothoracic and Vascular Anesthesia ◽

10.1016/1053-0770(92)90384-j ◽

1992 ◽

Vol 6 (1) ◽

pp. 38

Author(s):

P.D. McDonagh ◽

J. Billett ◽

W.P. Blunnie ◽

N. Murphy

Keyword(s):

Morphine Metabolites

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