Central nervous system binding sites for calcitonin and calcitonin gene-related peptide

1991 ◽  
Vol 5 (2-4) ◽  
pp. 251-273 ◽  
Author(s):  
Patrick M. Sexton
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Binding Sites ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites

1988 ◽  
Vol 463 (2) ◽  
pp. 223-244 ◽  
Author(s):  
Lawrence Kruger ◽  
Patrick W. Mantyh ◽  
Catia Sternini ◽  
Nicholas C. Brecha ◽  
Christopher R. Mantyh
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Receptor Binding ◽  
Binding Sites ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene

Comparative immunohistochemical distribution of amylin-like and calcitonin gene related peptide like immunoreactivity in the rat central nervous system

1995 ◽  
Vol 73 (7) ◽  
pp. 945-956 ◽  
Author(s):  
Gerhard Skofitseh ◽  
Wolfgang Gubisch ◽  
Sunil J. Wimalawansa ◽  
David M. Jacobowitz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebellar Nuclei ◽  
Calcitonin Gene Related Peptide ◽  
Polyclonal Antiserum ◽  
Related Peptide ◽  
Diagonal Band ◽  
Large Numbers ◽  
Calcitonin Gene ◽  
The Central Nervous System

Using the indirect immunofluorescence method with a polyclonal antiserum raised in rabbits and directed against amylin (AMY), we have investigated the distribution of AMY-like immunoreactivity (-ir) throughout the central nervous system of the rat. The widespread distribution of AMY-ir was much more abundant than that previously reported for calcitonin gene related peptide (CGRP) immunoreactivity. In most brain areas there was no overlap between AMY- and CGRP-ir cell body groupings, with the exception of the motor nuclei of the hindbrain and spinal cord, which were found to contain large numbers of AMY- and CGRP-immunoreactive cell bodies. Areas with a moderate to dense appearance of AMY-ir were the rhinencephalon, the nucleus of the diagonal band, the magnocellular, dorso- and ventro-medial and mammillary nuclei of the hypothalamus, the habenula, the compact part of the substantia nigra, the ruber and pontine nuclei, and the inferior olive and the cerebellar nuclei. The widespread immunohistochemical distribution of AMY-ir in the rat brain is in partial agreement with the distribution of AMY-binding sites.Key words: calcitonin gene related peptide, amylin, central nervous system, immunohistochemistry, rat.

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