scholarly journals Effects of Tetramethylpyrazine and Radix Salviae Miltiorrhizae on collagen synthesis and proliferation of cardiac fibroblasts

1998 ◽  
Vol 4 (4) ◽  
pp. 295-295
Author(s):  
Song Deming ◽  
Su Hai ◽  
Wu Meihua ◽  
Huang Xueming
Keyword(s):  
Collagen Synthesis ◽  
Cardiac Fibroblasts ◽  
Radix Salviae Miltiorrhizae ◽  
Salviae Miltiorrhizae

Luteolin Antagonizes Angiotensin II-Dependent Proliferation and Collagen Synthesis of Cultured rat Cardiac Fibroblasts

2015 ◽  
Vol 16 (5) ◽  
pp. 430-439 ◽  
Author(s):  
Tingting Wang ◽  
Defeng Pan ◽  
Yingying Zhang ◽  
Dongye Li ◽  
Yanbin Zhang ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Collagen Synthesis ◽  
Cardiac Fibroblasts

scholarly journals Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts

2021 ◽  
Vol 35 ◽  
pp. 100837
Author(s):  
Ruth R. Magaye ◽  
Feby Savira ◽  
Xin Xiong ◽  
Kevin Huynh ◽  
Peter J. Meikle ◽  
...  
Keyword(s):  
Collagen Synthesis ◽  
Cardiac Fibroblasts

Urotensin-2 promotes collagen synthesis via ERK1/2-dependent and ERK1/2-independent TGF-β1 in neonatal cardiac fibroblasts

2011 ◽  
Vol 35 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Hong‑Yan Dai ◽  
Tao He ◽  
Xiao‑Lu Li ◽  
Wen‑Liang Xu ◽  
Zhi‑Ming Ge
Keyword(s):  
Collagen Synthesis ◽  
Cardiac Fibroblasts ◽  
Tgf Β1

scholarly journals Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy

2016 ◽  
Vol 37 (6) ◽  
Author(s):  
Ritwik Datta ◽  
Trisha Bansal ◽  
Santanu Rana ◽  
Kaberi Datta ◽  
Ratul Datta Chaudhuri ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Collagen Synthesis ◽  
Cardiac Fibroblasts ◽  
Heat Shock Protein 90 ◽  
Signaling Mechanism ◽  
Content Type ◽  
Collagen Expression ◽  
Significant Difference

ABSTRACT Signal transducer and activator of transcription 3 (STAT-3)-mediated signaling in relation to upregulated collagen expression in fibroblasts during cardiac hypertrophy is well defined. Our recent findings have identified heat shock protein 90 (Hsp90) to be a critical modulator of fibrotic signaling in cardiac fibroblasts in this disease milieu. The present study was therefore intended to analyze the role of Hsp90 in the STAT-3-mediated collagen upregulation process. Our data revealed a significant difference between in vivo and in vitro results, pointing to a possible involvement of myocyte-fibroblast cross talk in this process. Cardiomyocyte-targeted knockdown of Hsp90 in rats (Rattus norvegicus) in which the renal artery was ligated showed downregulated collagen synthesis. Furthermore, the results obtained with cardiac fibroblasts conditioned with Hsp90-inhibited hypertrophied myocyte supernatant pointed toward cardiomyocytes' role in the regulation of collagen expression in fibroblasts during hypertrophy. Our study also revealed a novel signaling mechanism where myocyte-derived Hsp90 orchestrates not only p65-mediated interleukin-6 (IL-6) synthesis but also its release in exosomal vesicles. Such myocyte-derived exosomes and myocyte-secreted IL-6 are responsible in unison for the biphasic activation of STAT-3 signaling in cardiac fibroblasts that culminates in excess collagen synthesis, leading to severely compromised cardiac function during cardiac hypertrophy.

Improved stability of salvianolic acid B from Radix Salviae miltiorrhizae in deep eutectic solvents

2016 ◽  
Vol 8 (11) ◽  
pp. 2502-2509 ◽  
Author(s):  
Jue Chen ◽  
Shi-fei Li ◽  
Zhi-feng Yao ◽  
Da-wei Yang ◽  
Li-wei Zhang
Keyword(s):  
Environmentally Friendly ◽  
Deep Eutectic Solvents ◽  
Salvianolic Acid B ◽  
Radix Salviae Miltiorrhizae ◽  
Salvianolic Acid ◽  
Salviae Miltiorrhizae ◽  
Improved Stability ◽  
The Stability

Environmentally friendly deep eutectic solvents were developed for enhancing the stability of salvianolic acid B from Radix Salviae miltiorrhizae.

scholarly journals Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yu-Qiang Liu ◽  
Qian Cai ◽  
Chang Liu ◽  
Feng-Wei Bao ◽  
Zhen-Qiu Zhang
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rosmarinic Acid ◽  
Rat Plasma ◽  
Hplc Method ◽  
Radix Salviae Miltiorrhizae ◽  
Salviae Miltiorrhizae ◽  
Hawthorn Extract

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration ofRadix Salviae Miltiorrhizaeextract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.

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