A study on combination therapy of western and traditional Chinese medicine of acute viral myocarditis

1997 ◽  
Vol 3 (2) ◽  
pp. 119-119
Author(s):  
Wei Gu ◽  
Ying-Zhen Yang ◽  
Mei-Xian He
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Combination Therapy ◽  
Viral Myocarditis ◽  
Acute Viral Myocarditis

scholarly journals Xin Su Ning—A Review of Basic and Clinical Pharmacology Integrated With Traditional Chinese Medicine Antiarrhythmic Theory

2021 ◽  
Vol 12 ◽  
Author(s):  
Xuan Wang ◽  
Taiyi Wang ◽  
Shuwen Ding ◽  
Yu-Ling Ma
Keyword(s):  
Clinical Trial ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Pharmacological Study ◽  
Viral Myocarditis ◽  
Herbal Medicines ◽  
Premature Ventricular Contraction ◽  
Weight Coefficient ◽  
Double Blind ◽  
Tcm Theory

Xin Su Ning (XSN) is a patented multicomponent medicine, which was certified in 2005 by the China State Food and Drug Administration to be produced pharmaceutically and to be used clinically. The XSN capsule was developed from an effective formula composed by Prof. Shuwen Ding of Shandong University of Traditional Chinese Medicine. Through more than 30 years of clinical observation, Prof. Ding concluded that XSN has a significant effect on arrhythmia with phlegm-heat heart-disturbed syndrome according to the traditional Chinese medicine (TCM) diagnosis. XSN, derived from a classical TCM formula Huanglian Wen Dan Decoction, is formulated with 11 Chinese herbal medicines to treat cardiac ventricular arrhythmia. Clinical evidence suggests that it is particularly efficacious for the arrhythmias induced by cardiac ischemia and viral myocarditis without obvious adverse reactions being reported. Cellular electrophysiological studies in ventricular myocytes revealed that XSN prolongs the duration and suppresses the amplitude of the action potential (AP), which is supported by the blockage of sodium and potassium channels indicating the characteristics of class I and III antiarrhythmic drugs. A recently reported double-blind, placebo-controlled, multicenter clinical trial of XSN enrolled 861 patients (ChiCTR-TRC-14004180) and showed that XSN significantly inhibited premature ventricular contraction (PVC). The cellular electrophysiological discoveries provided the mechanistic evidence for the clinical efficacy on inhibition of PVC by XSN as demonstrated in the clinical trial. These studies, for the first time, provided exclusive evidence that multicomponent TCM antiarrhythmic medicine can be evaluated using conventional research methods that have been used for antiarrhythmic drug discoveries for decades. We aimed to give a comprehensive review on XSN including its origin with the support of TCM theory, its pre-licensing clinical use and development, and its pharmacological and clinical study discoveries. The review will be summarized with the discoveries reported in a novel network pharmacological study that introduced a weight coefficient, which made it possible to evaluate the pharmacological properties of the TCM formula with regard to its formation based on TCM theory. Limitations regarding XSN’s basic and clinical research and possible future studies are listed. We hope that the advances in how XSN was studied may offer useful guidance on how other TCM could be studied with respect to the integrity of the TCM formulas.

scholarly journals ALLERGIC RHINITICAL THERAPY WITH ACUPUNCTURE, LEGUNDI AND TEMULAWAK HERBS

2019 ◽  
Vol 2 (2) ◽  
pp. 60
Author(s):  
Maya Septriana ◽  
Novita Purnamasari ◽  
Herra Studiawan
Keyword(s):  
Allergic Rhinitis ◽  
Chinese Medicine ◽  
Acupuncture Therapy ◽  
Traditional Chinese Medicine ◽  
Combination Therapy ◽  
Immunoglobulin E ◽  
Nasal Congestion ◽  
Herbal Therapy ◽  
Runny Nose ◽  
Curcuma Xanthorrhiza

Background: Allergic rhinitis is an inflammatory disease of the nasal mucosa mediated by IgE (immunoglobulin E) with the main mediator histamine. Rhinitis in the science of Traditional Chinese Medicine (TCM) is called Bi Yuan (influenza) and Bi Zhi (nasal congestion). Cases of allergic rhinitis experienced by patients are complaints of repeated sneezing up to 10 times in the morning with rhinorrhea (runny nose). Patients classified as allergic rhinitis with differentiation of hot moist syndrome with splenic deficiency. Purpose: To prove the effect of acupuncture combination therapy on Yintang point (EXHN 3), Yinxiang (LI 20), Zusanli (ST 36), Taibai (SP 3) with herbal legundi (Vitex trifolia) and temulawak (Curcuma xanthorrhiza) in patients with allergic rhinitis. Methods: Handling allergic rhinitis with acupuncture and herbal therapy methods. Acupuncture therapy was carried out at Yintang point (EXHN 3), Yinxiang (LI 20), Zusanli (ST 36), Taibai (SP 3) with the principle of eliminating hot humidification and toning of the spleen. In herbal therapy, patients are given herbal legundi (Vitex trifolia) and ginger (Curcuma xanthorrhiza). Results: The active compounds viteosin-A, viteksikarpin, and vitetrifolin-E which can inhibit releasing  histamine and curcumin as anti-inflammatory have an effect on sneezing in allergic rhinitis. In handling allergic rhinitis, acupuncture therapy  given 12 times, once every two days. Herbal therapy  given for 14 times, taken every 2 days interval, 3 times a day with a dose of 5.2 grams of legundi and 4.2 grams of ginger. This therapy  overcome the symptoms of sneezing and rhinorrhea in allergic rhinitis. Conclusion: Acupuncture and herbal therapy can be used to overcome sneezing and rhinorrhea in allergic rhinitis.

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