Controlled release of all-trans-retinoic acid from PEGylated gelatin nanopaticles by enzymatic degradation

1999 ◽  
Vol 4 (3) ◽  
pp. 215-218 ◽  
Author(s):  
Kyung Jin Kim ◽  
Youngro Byun
Keyword(s):  
Retinoic Acid ◽  
Controlled Release ◽  
Enzymatic Degradation ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Gliadin nanoparticles for the controlled release of all-trans-retinoic acid

1996 ◽  
Vol 131 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Isabel Ezpeleta ◽  
Juan M. Irache ◽  
Serge Stainmesse ◽  
Christiane Chabenat ◽  
Jacques Gueguen ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Controlled Release ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

scholarly journals Effect of Size and Loading of Retinoic Acid in Polyvinyl Butyrate Nanoparticles on Amelioration of Colitis

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1472
Author(s):  
Jinting Li ◽  
Yunmei Mu ◽  
Yiwei Liu ◽  
Akihiro Kishimura ◽  
Takeshi Mori ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Controlled Release ◽  
Side Effects ◽  
Therapeutic Effect ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
High Concentrations

Butyrate has been used in the treatment of inflammatory bowel diseases (IBD). However, the controlled release of butyrate has been indicated to be necessary in order to avoid the side effects verified at high concentrations. We previously developed nanoparticles (NPs) of polyvinyl butyrate (PVBu) as an oral butyrate donor for the controlled release of butyrate for the treatment of colitis. To examine the effect of the size of NPs on the therapeutic effect of colitis, here we prepared PVBu NPs with different sizes (100 nm and 200 nm). Both sizes of PVBu NPs significantly suppressed the inflammatory response in macrophages in vitro. PVBu NPs with 200 nm showed better effects on the amelioration of colitis compared with the 100 nm-NPs. We found unexpectedly that 200 nm-NP incorporated with all-trans retinoic acid (ATRA) showed a much better therapeutic effect than those with unloaded 200 nm-NPs, although ATRA alone was reported to worsen the inflammation. The synergistic effect of ATRA with butyrate shows evidence of being a promising approach for IBD treatment.

Antiproliferative effect of all-trans-retinoic acid in cholangiocarcinoma

2017 ◽  
Author(s):  
A Prawan ◽  
S Butsri ◽  
V Kukongviriyapan ◽  
L Senggunprai ◽  
S Kongpetch
Keyword(s):  
Retinoic Acid ◽  
Antiproliferative Effect ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid
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