Comparison of protective effect of protein and DNA vaccines hsp90 in murine model of systemic candidiasis

2005 ◽  
Vol 50 (1) ◽  
pp. 77-82 ◽  
Author(s):  
M. Raska ◽  
J. Běláková ◽  
N. K. Wudattu ◽  
L. Kafková ◽  
K. Růžičková ◽  
...  
Keyword(s):  
Protective Effect ◽  
Murine Model ◽  
Dna Vaccines ◽  
Systemic Candidiasis

scholarly journals Immunogenicity and protective effect of recombinant enolase ofCandidaalbicansin a murine model of systemic candidiasis

2004 ◽  
Vol 42 (4) ◽  
pp. 319-324 ◽  
Author(s):  
Claudia Montagnoli ◽  
Silvia Sandini ◽  
Angela Bacci ◽  
Luigina Romani ◽  
Roberto La Valle
Keyword(s):  
Protective Effect ◽  
Murine Model ◽  
Systemic Candidiasis

scholarly journals HGP44 Induces Protection against Porphyromonas gingivalis-Induced Alveolar Bone Loss in Mice

2011 ◽  
Vol 18 (5) ◽  
pp. 888-891 ◽  
Author(s):  
Kyotaro Muramatsu ◽  
Eitoyo Kokubu ◽  
Takahiko Shibahara ◽  
Katsuji Okuda ◽  
Kazuyuki Ishihara
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
Porphyromonas Gingivalis ◽  
Murine Model ◽  
Alveolar Bone ◽  
Dna Vaccines ◽  
Alveolar Bone Loss ◽  
Content Type ◽  
Candidate Antigen

ABSTRACTThe protective effect of DNA vaccines expressing the Arg-gingipain A domain against bone loss induced byPorphyromonas gingivalisinfection was investigated in a murine model. phgp44, which expresses the 44-kDa adhesion/hemagglutinin domain of Arg-gingipain A, preventedP. gingivalis-induced alveolar bone loss. The results indicate that phgp44 could be a candidate antigen for a vaccine againstP. gingivalisinfection.

scholarly journals PCR-detectable Candida DNA exists a short period in the blood of systemic candidiasis murine model

2020 ◽  
Vol 15 (1) ◽  
pp. 677-682
Author(s):  
Zheng-Xin He ◽  
Hui-Hai Zhao ◽  
Fu-Kun Wang
Keyword(s):  
Heat Shock ◽  
Murine Model ◽  
Fungal Pathogens ◽  
Clinical Medicine ◽  
Diagnostic Techniques ◽  
Systemic Candidiasis ◽  
Blood Samples ◽  
Short Period ◽  
Polymerase Chain ◽  
Medicine Today

AbstractInvasive candidiasis is a major challenge to clinical medicine today. However, traditional fungal diagnostic techniques and empirical treatments have shown great limitations. Although efforts are necessarily needed in methodology standardization and multicenter validation, polymerase chain reaction (PCR) is a very promising assay in detecting fungal pathogens. Using a “heat-shock” DNA preparation method, a rapid and simple PCR protocol for quantification of the Candida albicans (C. albicans) ribosomal DNA was established. The PCR assay could detect Candida DNA as low as 10 CFU/mL in samples prepared by the heat-shock protocol, without any cross-reaction with DNA prepared from other Candida spp. and bacterial pathogens. For simulated blood samples, the PCR test sensitivity of whole blood samples was better than that of plasma and blood cells. In the systemic candidiasis murine model, detectable DNA was only observed within 24 h after C. albicans SC5314 injection, which is much shorter than that observed in the kidney.

Brain proteomic modifications associated to protective effect of grape extract in a murine model of obesity

2017 ◽  
Vol 1865 (5) ◽  
pp. 578-588 ◽  
Author(s):  
Selima Smine ◽  
Antoine Obry ◽  
Safwen Kadri ◽  
Julie Hardouin ◽  
Manuel Fréret ◽  
...  
Keyword(s):  
Protective Effect ◽  
Murine Model ◽  
Grape Extract

ORIGINAL ARTICLE: PD-1 but not CTLA-4 Blockage Abrogates the Protective Effect of Regulatory T Cells in a Pregnancy Murine Model

2009 ◽  
Vol 62 (5) ◽  
pp. 283-292 ◽  
Author(s):  
Paul Ojiambo Wafula ◽  
Ana Teles ◽  
Anne Schumacher ◽  
Kerstin Pohl ◽  
Hideo Yagita ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Protective Effect ◽  
Murine Model

The immunogenicity of Corynebacterium pseudotuberculosis protein and DNA vaccines in a murine model

2009 ◽  
Vol 128 (1-3) ◽  
pp. 314
Author(s):  
Keila da Silva Coelho ◽  
Anderson Miyoshi ◽  
Vasco Azevedo ◽  
Cristina Toscano Fonseca ◽  
Fernanda Caldas Cardoso ◽  
...  
Keyword(s):  
Murine Model ◽  
Dna Vaccines ◽  
Corynebacterium Pseudotuberculosis

Impact of serial systemic infection on Candida albicans virulence factors

2020 ◽  
Vol 15 (13) ◽  
pp. 1249-1263
Author(s):  
Glaucia S Arita ◽  
Daniella R Faria ◽  
Karina M Sakita ◽  
Franciele AV Rodrigues-Vendramini ◽  
Isis RG Capoci ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Virulence Factors ◽  
Murine Model ◽  
Systemic Infection ◽  
Systemic Candidiasis ◽  
Fungal Burden ◽  
Histopathological Findings ◽  
Phenotypic Profile ◽  
Proteomic Data ◽  
Repeated Contact

Aim: To evaluate changes in virulence and pathogenicity approaches from Candida albicans after successive passages in a murine model of systemic candidiasis. Materials & methods: Phenotypic assays were performed using colonies recovered from animals infected serially, totalizing five passages. Results: A progressive infection was observed along the passages, with increased fungal burden and the presence of greater inflammatory areas in the histopathological findings. Recovered strains exhibited increased filamentation and biofilm abilities, along with modulation of phospholipase and proteinase activities. Conclusion: Repeated contact between yeast and host increased the expression of virulence factors. Furthermore, a correspondence between phenotypic profile and proteomic data obtained previously was observed.

Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model

2019 ◽  
Vol 24 (10) ◽  
pp. 1272-1277 ◽  
Author(s):  
Armin Mooranian ◽  
Nassim Zamani ◽  
Giuseppe Luna ◽  
Hesham Al-Sallami ◽  
Momir Mikov ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Bile Acid ◽  
Protective Effect ◽  
Murine Model ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Diabetes Development
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