Overview of adrenal imaging/adrenal CT

1989 ◽  
Vol 11 (1) ◽  
pp. 221-226 ◽  
Author(s):  
Melvyn Korobkin
Keyword(s):  
Adrenal Imaging ◽  
Adrenal Ct

Pitfalls of adrenal imaging with chemical shift MRI

2014 ◽  
Vol 69 (11) ◽  
pp. 1186-1197 ◽  
Author(s):  
N. Schieda ◽  
O. Al Dandan ◽  
A.Z. Kielar ◽  
T.A. Flood ◽  
M.D.F. McInnes ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Adrenal Imaging ◽  
Chemical Shift Mri

scholarly journals Prospective evaluation of aldosterone LC-MS/MS-specific cutoffs for the saline infusion test

2020 ◽  
Vol 183 (2) ◽  
pp. 191-201
Author(s):  
Charlotte Michaela Fries ◽  
Yoon Ju Bae ◽  
Nada Rayes ◽  
Benjamin Sandner ◽  
Berend Isermann ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Sensitivity And Specificity ◽  
Medical Center ◽  
Challenge Test ◽  
Saline Infusion ◽  
University Hospital ◽  
Infusion Test ◽  
Cutoff Values ◽  
Adrenal Imaging ◽  
Design And Methods

Objective Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) has become state of the art for the quantitative analysis of steroid hormones. Although method comparisons show that aldosterone measurement using LC-MS/MS yields considerably lower levels than immunoassays (IAs), method-specific cutoff values for primary aldosteronism (PA) are largely missing. Objective of this study was to analyze the diagnostic accuracy of proposed LC-MS/MS-specific cutoff values for the saline infusion test (SIT). Design and methods From 2016 to 2019, 104 consecutive patients suspected of PA underwent the SIT and captopril challenge test in the tertiary medical center at the University Hospital of Leipzig, Germany. Patients with positive case confirmation underwent adrenal imaging and adrenal venous sampling for subtype classification. Results Overall, proposed assay-specific PACLC-MS/MS cutoff values for the SIT achieved higher diagnostic accuracy than established PACIA values with a sensitivity and specificity of 87.5% (95% CI: 71.0–96.5) and 97% (95% CI: 89.6–99.6) for a cutoff of 120 pmol/L and 93.8% (95% CI: 79.2–99.2) and 92.5% (95% CI: 83.4–97.5) for a cutoff of 94 pmol/L. The most accurate post-SIT PACLC-MS/MS cutoff value in this study was 83 pmol/L, yielding a sensitivity and specificity of 96.9% (95% CI: 83.8–99.9) and 92.5% (95% CI: 83.4–97.5), respectively. Conclusions The present data confirm the need for the implication of lower method-specific aldosterone cutoff values for the diagnosis of PA with LC-MS/MS based aldosterone measurement.

scholarly journals Giant bilateral adrenal lipoma in a patient with congenital adrenal hyperplasia

2021 ◽  
Vol 2021 ◽  
Author(s):  
Tina Kienitz ◽  
Jörg Schwander ◽  
Ulrich Bogner ◽  
Michael Schwabe ◽  
Thomas Steinmüller ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Abdominal Mass ◽  
Clinical Signs ◽  
Adrenal Tumors ◽  
List Type ◽  
Adrenal Hyperplasia ◽  
Endocrine Society ◽  
Adrenal Imaging ◽  
Open Laparotomy ◽  
The Right

Summary Apart from adrenal myelolipomas, adrenal lipomatous tumors are rare and only seldom described in the literature. We present the case of a 50-year-old man, with a classical form of congenital adrenal hyperplasia (CAH), which was well treated with prednisolone and fludrocortisone. The patient presented with pollakisuria and shortness of breath while bending over. On MRI, fat-equivalent masses were found in the abdomen (14 × 19 × 11 cm on the right side and 10 × 11 × 6 cm on the left side). The right adrenal mass was resected during open laparotomy and the pathohistological examination revealed the diagnosis of an adrenal lipoma. Symptoms were subdued totally postoperatively. This is the first report of a bilateral adrenal lipoma in a patient with CAH that we are aware of. Learning points Macronodular hyperplasia is common in patients with congenital adrenal hyperplasia (CAH). Solitary adrenal tumors appear in approximately 10% of adult CAH patients and are often benign myelolipomas. The Endocrine Society Clinical Practice Guideline does not recommend routine adrenal imaging in adult CAH patients. Adrenal imaging should be performed in CAH patients with clinical signs for an adrenal or abdominal mass. Adrenal lipoma is rare and histopathological examinations should rule out a differentiated liposarcoma.

scholarly journals Patients With Apparently Nonfunctioning Adrenal Incidentalomas May Be at Increased Cardiovascular Risk Due to Excessive Cortisol Secretion

2014 ◽  
Vol 99 (8) ◽  
pp. 2754-2762 ◽  
Author(s):  
Ioannis I. Androulakis ◽  
Gregory A. Kaltsas ◽  
Georgios E. Kollias ◽  
Athina C. Markou ◽  
Aggeliki K. Gouli ◽  
...  
Keyword(s):  
Low Dose ◽  
Area Under The Curve ◽  
Urinary Free Cortisol ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Acth Stimulation ◽  
Adrenal Imaging ◽  
Free Cortisol ◽  
Suppression Test ◽  
Dexamethasone Suppression

Context: Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with nonfunctioning AI (NFAI) have increased CVR. Objective: Our objective was to investigate CVR in patients with NFAI. Design and Setting: This case-control study was performed in a tertiary general hospital. Subjects: Subjects included 60 normotensive euglycemic patients with AI and 32 healthy controls (C) with normal adrenal imaging. Main Outcome Measures: All participants underwent adrenal imaging, biochemical and hormonal evaluation, and the following investigations: 1) measurement of carotid intima-media thickness (IMT) and flow-mediated dilatation, 2) 2-hour 75-gram oral glucose tolerance test and calculation of insulin resistance indices (homeostasis model assessment, quantitative insulin sensitivity check, and Matsuda indices), 3) iv ACTH stimulation test, 4) low-dose dexamethasone suppression test, and 5) NaCl (0.9%) post-dexamethasone saline infusion test. Results: Based on cutoffs obtained from controls, autonomous cortisol secretion was documented in 26 patients (cortisol-secreting AI [CSAI] group), whereas 34 exhibited adequate cortisol and aldosterone suppression (NFAI group). IMT measurements were higher and flow-mediated vasodilatation was lower in the CSAI group compared with both NFAI and C and in the NFAI group compared with C. The homeostasis model assessment index was higher and quantitative insulin sensitivity check index and Matsuda indices were lower in the CSAI and NFAI groups compared with C as well as in CSAI compared with the NFAI group. The area under the curve for cortisol after ACTH stimulation was higher in the CSAI group compared with the NFAI group and C and in the NFAI group compared with C. In the CSAI group, IMT correlated with cortisol, urinary free cortisol, and cortisol after a low-dose dexamethasone suppression test, whereas in the NFAI group, IMT correlated with area under the curve for cortisol after ACTH stimulation and urinary free cortisol. Conclusions: Patients with CSAI without hypertension, diabetes, and/or dyslipidemia exhibit adverse metabolic and CVR factors. In addition, NFAIs are apparently associated with increased insulin resistance and endothelial dysfunction that correlate with subtle but not autonomous cortisol excess.

Adrenal Imaging

2009 ◽  
pp. 1-20
Author(s):  
Khaled M. Elsayes ◽  
Isaac R. Francis ◽  
Melvyn Korobkin ◽  
Gerard M. Doherty
Keyword(s):  
Adrenal Imaging

Practical Approach to Adrenal Imaging

2017 ◽  
Vol 55 (2) ◽  
pp. 279-301 ◽  
Author(s):  
Khaled M. Elsayes ◽  
Sally Emad-Eldin ◽  
Ajaykumar C. Morani ◽  
Corey T. Jensen
Keyword(s):  
Practical Approach ◽  
Adrenal Imaging

Clinical Applications of Nuclear Adrenal Imaging

1977 ◽  
Vol 2 (8) ◽  
pp. 283-285
Author(s):  
Richard J. Mahler ◽  
Dwight K. Oxley
Keyword(s):  
Clinical Applications ◽  
Adrenal Imaging

scholarly journals Introduction to the special issue on adrenal imaging

2020 ◽  
Vol 45 (4) ◽  
pp. 891-891
Author(s):  
Khaled M. Elsayes
Keyword(s):  
Special Issue ◽  
Adrenal Imaging

scholarly journals Surgical Outcomes Among Primary Aldosteronism Patients Without Visible Adrenal Lesions

2020 ◽  
Author(s):  
Davis Sam ◽  
Gregory A Kline ◽  
Benny So ◽  
Janice L Pasieka ◽  
Adrian Harvey ◽  
...  
Keyword(s):  
Partial Response ◽  
Clinical Outcomes ◽  
Primary Aldosteronism ◽  
Retrospective Cohort ◽  
Primary Outcome ◽  
Tertiary Care ◽  
Adrenal Vein Sampling ◽  
Cross Sectional ◽  
Adrenal Imaging

Abstract Context Many patients with unilateral primary aldosteronism (PA) have normal adrenal imaging, but little is known about their outcome following adrenalectomy. Objective To evaluate biochemical and clinical outcomes after adrenalectomy in patients with unilateral PA and normal-appearing adrenal imaging. Design Retrospective cohort study of patients seen between January 2006 and May 2018. Setting A Canadian tertiary care PA referral center. Patients Consecutive individuals with PA, normal cross-sectional adrenal imaging, and lateralizing adrenal vein sampling (AVS) who underwent adrenalectomy during the study period. Primary Outcome Biochemical response to adrenalectomy graded according to the Primary Aldosteronism Surgical Outcome criteria. Results A total of 40 patients were included. Biochemical outcomes were available for 33 people (mean age, 54.7 years; 91% male; median follow-up, 2.7 months), with 28 (85%) showing a complete or partial response and 5 (15%) with no response. Clinical outcomes were available for 36 people (mean age, 54.6 years; 86% male; median follow-up, 9.8 months), with 31 (86%) demonstrating a complete or partial response and 5 (14%) with no response. Conclusions The prognosis after adrenalectomy is highly favorable for patients with unilateral PA and normal-appearing adrenal imaging. Patients with lateralizing disease should be considered for surgery despite apparently normal adrenal imaging.

Adrenal Imaging

2017 ◽  
Vol 46 (3) ◽  
pp. 741-759 ◽  
Author(s):  
Mishal Mendiratta-Lala ◽  
Anca Avram ◽  
Adina F. Turcu ◽  
N. Reed Dunnick
Keyword(s):  
Adrenal Imaging
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