Alterations of pancreatic amylase secretion in the reserpinized rat model of cystic fibrosis

1994 ◽  
Vol 16 (1) ◽  
pp. 37-44
Author(s):  
Jean Morisset ◽  
France-Line Béruhé ◽  
Micheline Vanier ◽  
Ouhida Benrezzak
Keyword(s):  
Cystic Fibrosis ◽  
Rat Model ◽  
Amylase Secretion ◽  
Pancreatic Amylase

scholarly journals Inherited Causes of Exocrine Pancreatic Dysfunction

1997 ◽  
Vol 11 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Peter R Durie
Keyword(s):  
Cystic Fibrosis ◽  
Lipase Activity ◽  
Exocrine Pancreas ◽  
Adult Life ◽  
Pancreatic Function ◽  
Amylase Secretion ◽  
Pancreatic Amylase ◽  
Pancreatic Dysfunction ◽  
Secondary Phenomenon ◽  
Hereditary Conditions

The exocrine pancreas is functionally immature at birth. Protease function is probably adequate, but lipase activity approximates 5% to 10% of adult values in the newborn and remains low in infancy. Pancreatic amylase secretion is essentially absent at birth and remains low through the first years of life. Functional disturbances of the exocrine pancreas are less frequent in childhood than in adult life. Causes of pancreatic dysfunction in childhood can be divided in two general categories: hereditary conditions, which directly affect the pancreas; and acquired disorders, in which loss of pancreatic function is a secondary phenomenon. Most inherited causes of pancreatic dysfunction are due to a generalized disorder. Cystic fibrosis is, by far, the most common inherited cause of disturbed pancreatic function among Caucasian children. All other inherited causes of exocrine pancreatic dysfunction (eg, Johanson-Blizzard syndrome) are uncommon or rare.

The effects of kynurenine on pancreatic amylase secretion in the rats

Pancreatology ◽  
2012 ◽  
Vol 12 (6) ◽  
pp. 509
Author(s):  
K. Nawrot-Porąbka ◽  
A. Leja-Szpak ◽  
J. Jaworek
Keyword(s):  
Amylase Secretion ◽  
Pancreatic Amylase

Presynaptic inhibition by serotonin of nerve-mediated secretion of pancreatic amylase

1995 ◽  
Vol 268 (2) ◽  
pp. G339-G345 ◽  
Author(s):  
A. L. Kirchgessner ◽  
M. D. Gershon
Keyword(s):  
Presynaptic Inhibition ◽  
Cholinergic Neurons ◽  
Acinar Cells ◽  
Presynaptic Receptors ◽  
Amylase Secretion ◽  
Pancreatic Amylase ◽  
Inhibitory Receptor ◽  
Cholinergic Nerves ◽  
Positive Identification ◽  
Fos Expression

Enteric cholinergic and serotonergic neurons innervate pancreatic ganglia. Enteropancreatic cholinergic neurons are secretomotor, bu the function of the serotonergic cells is unknown and was investigated. Postganglionic cholinergic nerve-mediated amylase secretion was evoked by veratridine in isolated pancreatic lobules. This concentration-dependent response was inhibited by tetrodotoxin (1.0 microM), atropine (5.0 microM), 5-hydroxytryptamine (5-HT; 5.0 microM), 5-hydroxyindalpine (5-OHIP; 10.0 microM; a 5-HT1P agonist), and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.1 microM), but not by hexamethonium (100.0 microM), 2-methyl-5-HT (10 microM), or 5-carboxyamidotryptamine (10 microM). The effects of 5-HT and 5-OHIP were blocked by the 5-HT1P antagonist N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide (5-HTP-DP; 100.0 microM). Carbachol (5.0 microM)-evoked secretion was not affected by 5-HT or 5-OHIP. Veratridine induced c-fos expression in pancreatic neurons and acinar cells. This expression was inhibited by tetrodotoxin, 5-HT, and 5-OHIP. These observations suggest that the serotonergic enteropancreatic innervation inhibits pancreatic secretion via presynaptic receptors on cholinergic nerves. Although the data are consistent with the hypothesis that the inhibitory receptor is a 5-HT1P site, positive identification awaits further study.

Morphological and histochemical changes in intestinal mucosa in the reserpine-treated rat model of cystic fibrosis

1987 ◽  
Vol 47 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Carol M. Park ◽  
Philip E. Reid ◽  
David A. Owen ◽  
John M. Sanker ◽  
Derek A. Applegarth
Keyword(s):  
Cystic Fibrosis ◽  
Intestinal Mucosa ◽  
Rat Model ◽  
Histochemical Changes

Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro

2004 ◽  
Vol 36 (3) ◽  
pp. 155-164 ◽  
Author(s):  
Jolanta Jaworek ◽  
Katarzyna Nawrot ◽  
Stanisław J. Konturek ◽  
Anna Leja-Szpak ◽  
Piotr Thor ◽  
...  
Keyword(s):  
Amylase Secretion ◽  
Pancreatic Amylase

Galanin: structure-dependent effect on pancreatic amylase secretion and jejunal strip contraction

1993 ◽  
Vol 240 (2-3) ◽  
pp. 259-267 ◽  
Author(s):  
Wojciech J. Rossowski ◽  
Susan Zacharia ◽  
Ning-Yi Jiang ◽  
Zeynel Mungan ◽  
Michael Mills ◽  
...  
Keyword(s):  
Amylase Secretion ◽  
Pancreatic Amylase ◽  
Dependent Effect

High amount of dietary carbohydrate does not cause an adaptational increase of stimulated human pancreatic amylase secretion

1989 ◽  
Vol 4 (4) ◽  
Author(s):  
Ralf-Marco Liehr ◽  
Maria-Elisabeth Herrmann ◽  
Carsten Emde ◽  
Rüdiger Hopert ◽  
Ernst-Otto Riecken
Keyword(s):  
Amylase Secretion ◽  
Pancreatic Amylase ◽  
Dietary Carbohydrate
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