The study of endocrine tumors by flow and image cytometry

Multiple endocrine neoplasia is characterized with a predisposition to tumors involving two or more endocrine glands. The four main forms of the disease are inherited as an autosomal dominant syndrome or may occur sporadically. In addition to these four forms, six other syndromes are associated with the presence of multiple endocrine and other neoplasms of the organs: hyperparathyroidism − jaw tumors, Carney complex, von Hippel−Lindau disease, neurofibromatosis type 1, Cowden syndrome and McCune − Albright syndrome. The diagnosis of multiple endocrine neoplasia syndrome can be established in humans by one of the three available criteria: clinical features, family history, genetic analysis. Mutation analysis during these syndromes is useful in clinical practice to confirm the clinical diagnosis; identifying family members who tolerate the mutation and need to be screened, and identifying family members who do not tolerate the mutation. Syndrome of multiple endocrine neoplasia (Wermer syndrome) is characterized by the presence of a triad of tumors, including tumors of the parathyroid glands, pheochromocytoma and tumors of the parathyroid gland. It occurs less frequently in combination with Hirschsprung's disease, caused by the absence of vegetative ganglion cells in the intestine terminal parts, that leads to colonic enlargement, severe constipation and obstruction. This syndrome may be associated with cutaneous lichen amyloidosis, the clinical manifestations of which are pruritus and lichenoid lesions, usually located in the upper back. A clinical case of MEN2 syndrome in a 52−year−old patient is presented. It is noted that for such patients, in addition to timely syndromic rather than component diagnosis of this endocrine multipathology, the spread of neoplastic process in medullary thyroid cancer to its capsule and surrounding tissues, as well as the presence of metastases in peripheral lymph nodes are important. As a rule, such patients cannot be timely cured. Key words: multiple endocrine neoplasia, endocrine tumors, genetic analysis, family history.

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Object relocation in automated image cytometry

Bioimaging ◽

10.1002/1361-6374(199403)2:1<62::aid-bio6>3.3.co;2-f ◽

1994 ◽

Vol 2 (1) ◽

pp. 62-68 ◽

Cited By ~ 1

Author(s):

Ian Poole ◽

Andrew Carothers ◽

Derek Charleston

Keyword(s):

Image Cytometry

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A Phase II Trial of Bevacizumab with Capecitabine in Progressive, Metastatic Well-Differentiated Digestive Endocrine Tumors (Better Study)

Annals of Oncology ◽

10.1016/s0923-7534(20)33730-3 ◽

2012 ◽

Vol 23 ◽

pp. ix378

Author(s):

T.A. Walter ◽

E. Baudin ◽

J.E. Kurtz ◽

P. Ruszniewski ◽

L. Bengrine-Lefevre ◽

...

Keyword(s):

Phase Ii ◽

Phase Ii Trial ◽

Endocrine Tumors ◽

Well Differentiated

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High-throughput viral microneutralization method for feline coronavirus using image cytometry

Journal of Virological Methods ◽

10.1016/j.jviromet.2020.113979 ◽

2020 ◽

Vol 286 ◽

pp. 113979

Author(s):

Morgan Pearson ◽

Alora LaVoy ◽

Leo Li-Ying Chan ◽

Gregg A. Dean

Keyword(s):

High Throughput ◽

Image Cytometry ◽

Feline Coronavirus

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Quantitative image analysis of microbial communities with BiofilmQ

Nature Microbiology ◽

10.1038/s41564-020-00817-4 ◽

2021 ◽

Author(s):

Raimo Hartmann ◽

Hannah Jeckel ◽

Eric Jelli ◽

Praveen K. Singh ◽

Sanika Vaidya ◽

...

Keyword(s):

Image Analysis ◽

Microbial Communities ◽

Dimensional Space ◽

Three Dimensional ◽

Software Tool ◽

Image Cytometry ◽

Quantitative Image Analysis ◽

Space And Time ◽

Quantitative Image ◽

Three Dimensional Space

AbstractBiofilms are microbial communities that represent a highly abundant form of microbial life on Earth. Inside biofilms, phenotypic and genotypic variations occur in three-dimensional space and time; microscopy and quantitative image analysis are therefore crucial for elucidating their functions. Here, we present BiofilmQ—a comprehensive image cytometry software tool for the automated and high-throughput quantification, analysis and visualization of numerous biofilm-internal and whole-biofilm properties in three-dimensional space and time.

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